1,2-O-dioctadecyl-sn-glycerol | 1030613-96-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,2-O-dioctadecyl-sn-glycerol
• CAS: 1030613-96-7
• 化学式: C₄₀H₈₂O₃
• 分子量: 611.089
• InChiKey: HQLXHXRVONWEGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.15
• 重原子数：
  43.0
• 可旋转键数：
  39.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.69
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  1,2-O-dioctadecyl-sn-glycerol 在 四溴化碳 、 三苯基膦 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  Homochiral Supramolecular Polymerization of an “S”-Shaped Chiral Monomer:  Translation of Optical Purity into Molecular Weight Distribution

  摘要：

  An "S"-shaped chiral motif of a p-xylylene-bridged bis(cyclic dipeptide) (1), having four hydrogen-bonding amide functionalities, formed a homochiral supramolecular polymer in solution. X-ray crystallography of a slightly modified version of 1 for an enhanced crystallinity showed one-dimensional columnar assemblies via four double hydrogen-bonding interactions. Model studies with half-protected analogues of 1 indicated a nearly perfect enantioselectivity in hydrogen-bonding dimerization. When 1 was not racemic but enriched in either of the enantiomers, a supramolecular polymer with a bimodal molecular weight distribution resulted, due to the formation of two homochiral polymers with different molecular weights. By taking advantage of this, separation of optically pure 1 from an enantiomerically unbalanced mixture was possible by means of size-exclusion chromatography.

  DOI：

  10.1021/ja028403h
• 作为产物：
  描述：

  sodium octadecylate 在 9-borabicyclo[3.3.1]nonane dimer 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 生成 1,2-O-dioctadecyl-sn-glycerol
  参考文献：
  名称：

  Homochiral Supramolecular Polymerization of an “S”-Shaped Chiral Monomer:  Translation of Optical Purity into Molecular Weight Distribution

  摘要：

  An "S"-shaped chiral motif of a p-xylylene-bridged bis(cyclic dipeptide) (1), having four hydrogen-bonding amide functionalities, formed a homochiral supramolecular polymer in solution. X-ray crystallography of a slightly modified version of 1 for an enhanced crystallinity showed one-dimensional columnar assemblies via four double hydrogen-bonding interactions. Model studies with half-protected analogues of 1 indicated a nearly perfect enantioselectivity in hydrogen-bonding dimerization. When 1 was not racemic but enriched in either of the enantiomers, a supramolecular polymer with a bimodal molecular weight distribution resulted, due to the formation of two homochiral polymers with different molecular weights. By taking advantage of this, separation of optically pure 1 from an enantiomerically unbalanced mixture was possible by means of size-exclusion chromatography.

  DOI：

  10.1021/ja028403h

文献信息

• Poly(oxanorbornenedicarboximide)s dendronized with amphiphilic poly(alkyl ether) dendrons
  作者：Xiaoli Liang、Mani K. Sen、Jo-Ann Jee、Oleg Gelman、Jeannette E. Marine、Kenneth Kan、Maya K. Endoh、Deborah A. Barkley、Tadanori Koga、Jonathan G. Rudick

  DOI：10.1002/pola.27385

  日期：2014.11.15

  nanometer‐sized dimensions called dendronized polymers. The structure of these complex molecular architectures is highly tunable and, therefore, of interest for a wide range of potential applications. The first examples of dendronized polymers prepared by living ring‐opening metathesis polymerization of oxanorbornenedicarboximide macromonomers with poly(alkyl ether) dendrons are reported. Small‐angle X‐ray

  将树枝状分支的侧链连接到线性聚合物的每个重复单元上，会产生纳米尺寸的分子构建基团，称为树枝状聚合物。这些复杂的分子结构的结构是高度可调的，因此对于广泛的潜在应用是令人感兴趣的。报道了通过氧杂降冰片烯二羧酰亚胺大分子单体与聚（烷基醚）树突的开环易位聚合反应制备的树突化聚合物的第一个实例。散装样品的小角度X射线散射实验证实，可以通过选择树突的生成或烃外围基团的长度来定制单个圆柱状聚合物的直径。基于核-壳模型对SAXS数据的分析表明，尽管圆柱体的直径随世代的增加而增加，但核的大小并没有改变。这表明这些树枝状分子仅松散地包封了聚合物主链。©2014 Wiley Periodicals，Inc. J. Polym。科学，A部分：Polym。化学2014，52，3221-3239
• Self-Assembling Behavior of Amphiphilic Dendron Coils in the Bulk Crystalline and Liquid Crystalline States
  作者：Yeon-Wook Chung、Jeong-Kyu Lee、Wang-Cheol Zin、Byoung-Ki Cho

  DOI：10.1021/ja801163m

  日期：2008.6.1

  and a poly(ethylene oxide) (PEO) coil (DP = 44). The molecular design in this study is focused on the variation of dendron generation (from first to third) with a fixed linear coil, upon which the thermal and self-assembling behavior of the dendron coils was investigated in the bulk. All the dendron coils exhibit two crystalline phases designated as k1 (both crystalline octadecyl chains and PEO) and

  我们制备了一系列包含具有十八烷基外围的脂肪族聚醚树突和聚（环氧乙烷）（PEO）线圈（DP = 44）的两亲树突线圈（1-3）。本研究中的分子设计侧重于固定线性线圈的树突生成（从第一个到第三个）的变化，在此基础上，大量研究了树突线圈的热和自组装行为。所有树枝状线圈都表现出两个结晶相，称为 k1（结晶十八烷基链和 PEO）和 k2 状态（结晶十八烷基链和熔融 PEO）。十八烷基外围和 PEO 的结晶度随着生成量的增加而降低。特别是，含有第三代的树枝状线圈（3）显示出 PEO 结晶度的急剧下降，这归因于最大的亲水性树枝状核段产生的相当大的链折叠和增塑作用。所有的结晶相都是双层层状形态。从 k1 到 k2，第一代树枝状线圈 (1) 中周期性层状厚度减小，但有趣的是在 3 中增加。十八烷基外围熔化后，1 显示没有中间相（即液晶相）。此外，树枝状线圈 2 (3) 显示具有 Ia3d 对称性的网络立方中间相（具有
• Chemically Programmed Cell Adhesion with Membrane-Anchored Oligonucleotides
  作者：Nicholas S. Selden、Michael E. Todhunter、Noel Y. Jee、Jennifer S. Liu、Kyle E. Broaders、Zev J. Gartner

  DOI：10.1021/ja2080949

  日期：2012.1.18

  Cell adhesion organizes the structures of tissues and mediates their mechanical, chemical, and electrical integration with their surroundings. Here, we describe a strategy for chemically controlling cell adhesion using membrane-anchored single-stranded DNA oligonucleotides. The reagents are pure chemical species prepared from phosphoramidites synthesized in a single chemical step from commercially available starting materials. The approach enables rapid, efficient, and tunable cell adhesion, independent of proteins or glycans, by facilitating interactions with complementary labeled surfaces or other cells. We demonstrate the utility of this approach by imaging drug-induced changes in the membrane dynamics of non-adherent human cells that are chemically immobilized on a passivated glass surface.