(R,R)-1,5-bis[3-[3-(3,4-dimethoxyphenyl)-1-hydroxypropyl]phenoxy]-3-oxapentane | 195202-15-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (R,R)-1,5-bis[3-[3-(3,4-dimethoxyphenyl)-1-hydroxypropyl]phenoxy]-3-oxapentane
• 英文别名: (1R)-3-(3,4-dimethoxyphenyl)-1-[3-[2-[2-[3-[(1R)-3-(3,4-dimethoxyphenyl)-1-hydroxypropyl]phenoxy]ethoxy]ethoxy]phenyl]propan-1-ol
• CAS: 195202-15-4
• 化学式: C₃₈H₄₆O₉
• 分子量: 646.778
• InChiKey: GKULMVXHFFQYQU-KKLWWLSJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  47
• 可旋转键数：
  20
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  (S)-1-(3,3-二甲基-2-氧戊烷酰基)哌啶-2-羧酸 、 (R,R)-1,5-bis[3-[3-(3,4-dimethoxyphenyl)-1-hydroxypropyl]phenoxy]-3-oxapentane 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以56%的产率得到[(1R)-3-(3,4-dimethoxyphenyl)-1-[3-[2-[2-[3-[(1R)-3-(3,4-dimethoxyphenyl)-1-[(2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carbonyl]oxypropyl]phenoxy]ethoxy]ethoxy]phenyl]propyl] (2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
  参考文献：
  名称：

  Synthesis and activity of bivalent FKBP12 ligands for the regulated dimerization of proteins

  摘要：

  The total synthesis and in vitro activities of a series of chemical inducers of dimerization (CIDs) is described. The use of small-molecule CIDs to control the dimerization of engineered FKBP12-containing fusion proteins has been demonstrated to have broad utility in biological research as well as potential medical applications in gene and cell therapies. The facility and flexibility of preparation make this new class of wholly synthetic compounds exceptionally versatile tools for the study of intracellular signaling events mediated by protein-protein interactions or protein localization. While some congeners possess potency comparable to or better than the first generation natural product-derived CID, FK1012, structure-activity relationships are complex and underscore the need for application-specific compound optimizations. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(98)00125-4
• 作为产物：
  描述：

  3-羟基苯乙酮 在 Lindlar's catalyst 氢氧化钾 、 氢气 、 sodium hydride 、 (+)-二异松蒎基氯硼烷 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 、 N,N-二甲基甲酰胺 为溶剂， -20.0~20.0 ℃ 、344.74 kPa 条件下， 反应 38.0h， 生成 (R,R)-1,5-bis[3-[3-(3,4-dimethoxyphenyl)-1-hydroxypropyl]phenoxy]-3-oxapentane
  参考文献：
  名称：

  Synthesis and activity of bivalent FKBP12 ligands for the regulated dimerization of proteins

  摘要：

  The total synthesis and in vitro activities of a series of chemical inducers of dimerization (CIDs) is described. The use of small-molecule CIDs to control the dimerization of engineered FKBP12-containing fusion proteins has been demonstrated to have broad utility in biological research as well as potential medical applications in gene and cell therapies. The facility and flexibility of preparation make this new class of wholly synthetic compounds exceptionally versatile tools for the study of intracellular signaling events mediated by protein-protein interactions or protein localization. While some congeners possess potency comparable to or better than the first generation natural product-derived CID, FK1012, structure-activity relationships are complex and underscore the need for application-specific compound optimizations. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(98)00125-4

文献信息

• Synthetic Multimerizing Agents
  申请人：Holt Dennis A.

  公开号：US20120130076A1

  公开（公告）日：2012-05-24

  New compounds are disclosed for multimerizing immunophilins and proteins containing immunophilin or immunophilin-related domains. The compounds are of the formula M-L-Q where M is a synthetic ligand for an FKBP protein.

  新化合物被披露用于多聚免疫蛋白和含有免疫蛋白或免疫蛋白相关域的蛋白质。这些化合物的化学式为M-L-Q，其中M是FKBP蛋白的合成配体。
• US8106191B2
  申请人：——

  公开号：US8106191B2

  公开（公告）日：2012-01-31
• US8436183B2
  申请人：——

  公开号：US8436183B2

  公开（公告）日：2013-05-07
• Synthesis and activity of bivalent FKBP12 ligands for the regulated dimerization of proteins
  作者：Terence Keenan、David R. Yaeger、Nancy L. Courage、Carl T. Rollins、Mary Ellen Pavone、Victor M. Rivera、Wu Yang、Tao Guo、Jane F. Amara、Tim Clackson、Michael Gilman、Dennis A. Holt

  DOI：10.1016/s0968-0896(98)00125-4

  日期：1998.8

  The total synthesis and in vitro activities of a series of chemical inducers of dimerization (CIDs) is described. The use of small-molecule CIDs to control the dimerization of engineered FKBP12-containing fusion proteins has been demonstrated to have broad utility in biological research as well as potential medical applications in gene and cell therapies. The facility and flexibility of preparation make this new class of wholly synthetic compounds exceptionally versatile tools for the study of intracellular signaling events mediated by protein-protein interactions or protein localization. While some congeners possess potency comparable to or better than the first generation natural product-derived CID, FK1012, structure-activity relationships are complex and underscore the need for application-specific compound optimizations. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.