3-hydroxy-5-methyladamantane-1-carboxylic acid | 24674-97-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-hydroxy-5-methyladamantane-1-carboxylic acid
• CAS: 24674-97-3
• 化学式: C₁₂H₁₈O₃
• 分子量: 210.273
• InChiKey: LSSPUDFIBQOQLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-甲基金刚烷-1-羧酸 在 硝酸 、 溶剂黄146 、 尿素 作用下， 以 水 为溶剂， 反应 5.0h， 生成 3-hydroxy-5-methyladamantane-1-carboxylic acid
  参考文献：
  名称：

  一锅合成笼型醇

  摘要：

  已经开发出一种有效的一锅法程序，用于合成在桥头位置具有羟基的笼型醇。该程序包括先用硝酸或硝酸与乙酸的混合物进行硝化，然后在尿素存在下进行水解。

  DOI：

  10.1134/s1070428017070028

文献信息

• Synthesis of (3-Hydroxyadamantan-1-yl)methanols
  作者：E. A. Ivleva、A. V. Pogulyaiko、Yu. N. Klimochkin

  DOI：10.1134/s107042801809004x

  日期：2018.9

  of adamantan-1-ylmethanols with fuming nitring acid and subsequent reduction of intermediate nitric acid esters with hydrazine hydrate. The title diols have also been obtained by the reduction of 1-nitroxy-3-(nitroxymethyl)adamantanes. The nitroxylation process is accompanied by oxidation with the formation of substituted adamantane-1-carboxylic acids.

  已经开发了一种便利的方法，用于以烟酰胺硝化酸将金刚烷-1-基甲醇硝化并随后用水合肼还原中间体硝酸酯来合成（3-羟基金刚烷-1-基）-甲醇。通过还原1-硝基-3-（硝基甲基）金刚烷也获得了标题二醇。硝基氧化过程伴随着氧化，形成取代的金刚烷-1-羧酸。
• ADAMANTANE DERIVATIVES AND PROCESS FOR PRODUCING THEM
  申请人：Daicel Chemical Industries, Ltd.

  公开号：EP0927711A1

  公开（公告）日：1999-07-07

  In the presence of an imide compound (e.g., N-hydroxyphthalimide) shown by the formula (2):    wherein R1 and R2 independently represents a hydrogen atom, a halogen atom, an alkyl group, an aryl group, a cycloalkyl group; or R1 and R2 may bond together to form a double bond or an aromatic or non-aromatic ring; Y is O or OH and n = 1 to 3; or the imide compound and a co-catalyst (e.g., a transition metal compound), an adamantane derivative having a functional group such as a nitro group, an amino group, a hydroxyl group, a carboxyl group, a hydroxymethyl group and an isocyanato group is oxidized with oxygen. According to the above method, an adamantane derivative having a hydroxyl group together with a functional group such as a nitro group, an amino group, a hydroxyl group, a carboxyl group, a hydroxymethyl group and an isocyanato group is efficiently obtained.

  在存在式（2）所示的酰亚胺化合物（如 N-羟基邻苯二甲酰亚胺）的情况下： 其中 R1 和 R2 分别代表氢原子、卤素原子、烷基、芳基、环烷基；或 R1 和 R2 可键合在一起形成双键或芳香环或非芳香环；Y 为 O 或 OH，n = 1 至 3； 或亚胺化合物和助催化剂（如过渡金属化合物），具有诸如硝基、氨基、羟基、羧基、羟甲基和异氰酸基等官能团的金刚烷衍生物与氧发生氧化反应。根据上述方法，可有效地获得具有羟基和硝基、氨基、羟基、羧基、羟甲基和异氰酸基等官能团的金刚烷衍生物。
• RADIATION-SENSITIVE RESIN COMPOSITION
  申请人：JSR Corporation

  公开号：EP1602975A1

  公开（公告）日：2005-12-07

  A radiation-sensitive resin composition comprising an acid-labile group-containing resin obtained by living radical polymerization having a specific structure which is insoluble or scarcely soluble in alkali, but becomes alkali soluble by the action of an acid, and a photoacid generator, wherein the ratio of weight average molecular weight to number average molecular weight (weight average molecular weight/number average molecular weight) of the acid-labile group-containing-resin is smaller than 1.5.

  一种辐射敏感树脂组合物，包括一种通过活自由基聚合获得的具有特定结构的含酸基团树脂，该树脂不溶于碱或几乎不溶于碱，但在酸的作用下可溶于碱，还包括一种光酸发生器，其中含酸基团树脂的重量平均分子量与数量平均分子量之比（重量平均分子量/数量平均分子量）小于 1.5。
• NOVEL ALICYCLIC ESTER COMPOUND, AND (METH)ACRYLIC COPOLYMER AND PHOTOSENSITIVE RESIN COMPOSITION CONTAINING SAME
  申请人：Mitsubishi Gas Chemical Company, Inc.

  公开号：EP2990425A1

  公开（公告）日：2016-03-02

  [Problem to be solved] The present invention provides, as a chemically amplified resist, a well-balanced resist or compound which results in improved sensitivity, resolution and line edge roughness (LER) without impairing the fundamental physical properties required as a resist (e.g., pattern shape, dry etching resistance, heat resistance). [Means to solve the problem] A mixture of cycloaliphatic ester compounds represented by general formulae (1) to (3), and a process for preparation thereof, as well as a (meth)acrylic copolymer comprising the cycloaliphatic ester compounds of general formulae (1) to (3) and a photosensitive resin composition thereof.

  [有待解决的问题］ 本发明作为一种化学放大抗蚀剂，提供了一种平衡良好的抗蚀剂或化合物，它能提高灵敏度、分辨率和线边缘粗糙度（LER），而不损害作为抗蚀剂所需的基本物理特性（如图案形状、耐干蚀性、耐热性）。 [解决问题的方法］ 通式(1)至(3)表示的环脂族酯化合物的混合物及其制备方法，以及由通式(1)至(3)的环脂族酯化合物组成的（甲基）丙烯酸共聚物及其感光树脂组合物。
• SCREENING METHODS FOR AMYLOID BETA MODULATORS
  申请人：Slon-Usakiewicz Jacek

  公开号：US20110028719A1

  公开（公告）日：2011-02-03

  The present invention relates to methods for screening, identifying, and/or quantifying modulators of amyloid and/or aggregates, fibrils or components thereof, in particular modulators of amyloid β-peptide (Aβ) or Aβ fibrils. Aspects of the invention provide methods for screening putative modulators against an Amyloid target, in particular an Aβ target, so as to determine which modulators bind to or interact with the target, or interfere with the interaction of an indicator agent and the target. Particular aspects of the invention employ mass spectrometric methods for the screening of an Amyloid target against compound libraries, in particular mixtures of compounds or combinatorial libraries.