Synthesis-Guided Structure Revision of the Sarcodonin, Sarcoviolin, and Hydnellin Natural Product Family
作者:David W. Lin、Takeshi Masuda、Moritz B. Biskup、Jonathan D. Nelson、Phil S. Baran
DOI:10.1021/jo102228j
日期:2011.2.18
extensive studies aimed at their chemical synthesis. Key features of revised structure 1b include replacement of the N,N-dioxide moiety with an oxime, ring-opening of the central diketopiperazine, and transposition of the terphenyl wing from the 1β−2β position of 1a to the 2β−3β position of 1b. This structure revision arose from the serendipitous synthesis of a benzodioxane aminal (44) whose structure