2-phenyl-cyclohex-1-enecarboxylic acid amide | 807351-72-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 2-phenyl-cyclohex-1-enecarboxylic acid amide
• 英文别名: 2-Phenyl-cyclohex-1-encarbonsaeure-amid；2-Phenylcyclohexene-1-carboxamide
• CAS: 807351-72-0
• 化学式: C₁₃H₁₅NO
• 分子量: 201.268
• InChiKey: RKYAWDZATHSUJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-phenyl-cyclohex-1-enecarboxylic acid amide 在 硫酸 、 溶剂黄146 、 sodium nitrite 作用下， 生成 2-phenylcyclohex-1-enecarboxylic acid
  参考文献：
  名称：

  The Dehydration of 2-Phenylcyclohexanone Cyanohydrin: 6-Phenyl-Δ¹-cyclohexenecarbonitrile and 2-Phenyl-Δ¹-cyclohexenecarbonitrile

  摘要：

  DOI：

  10.1021/jo01107a013
• 作为产物：
  描述：

  1,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbonitrile 在 硫酸 、 sodium isopropylate 、 溶剂黄146 、 异丙醇 作用下， 生成 2-phenyl-cyclohex-1-enecarboxylic acid amide
  参考文献：
  名称：

  The Dehydration of 2-Phenylcyclohexanone Cyanohydrin: 6-Phenyl-Δ¹-cyclohexenecarbonitrile and 2-Phenyl-Δ¹-cyclohexenecarbonitrile

  摘要：

  DOI：

  10.1021/jo01107a013

文献信息

• HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP1472226A1

  公开（公告）日：2004-11-03
• [EN] HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS<br/>[FR] COMPOSES D'AMIDE HETEROCYCLIQUES EN TANT QU'INHIBITEURS DE L'APOLIPOPROTEINE B
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2003045921A1

  公开（公告）日：2003-06-05

  The present invention relates to a compound of the formula (I) wherein R1 is optionally substituted aryl; R2 is optionally substituted aryl, optionally substituted heteroaryl, optionally substituted lower cycloalkyl, optionally substituted aryloxy, optionally substituted arylsulfonyl, vinyl, carbamoyl, protected carboxy or protected amino; ring A is bivalent residue derived from optionally substituted aryl or optionally substituted heteroaryl; X is bivalent residue derived from the group consisting of cycloalkene, naphthalene, unsaturated 5 or 6-membered heteromonocyclic group, each of which is optionally substituted, and substituted benzene; Y is -(A1)m1-(A2)m2-; and Z is direct bond or piperazine, or a salt thereof. The compound of the present invention and a salt thereof inhibit apolipoprotein B (Apo B) secretion and are useful as a medicament for prophylactic and treatment of diseases or conditions resulting from elevated circulating levels of Apo B.
• The Dehydration of 2-Phenylcyclohexanone Cyanohydrin: 6-Phenyl-Δ¹-cyclohexenecarbonitrile and 2-Phenyl-Δ¹-cyclohexenecarbonitrile
  作者：WILLIAM E. PARHAM、WILBUR N. MOULTON、ALEXANDER ZUCKERBRAUN

  DOI：10.1021/jo01107a013

  日期：1956.1