1-丙-2-炔基-环己烯 | 854753-36-9

• 分子结构分类: 有机化合物 - 碳氢化合物 - 不饱和烃
• 中文名称: 1-丙-2-炔基-环己烯
• 英文名称: 1-prop-2-ynyl-cyclohexene
• 英文别名: 1-Prop-2-inyl-cyclohexen；1-Prop-2-ynylcyclohexene
• CAS: 854753-36-9
• 化学式: C₉H₁₂
• 分子量: 120.194
• InChiKey: OZYXWWWWTDBLEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1-丙-2-炔基-环己烯 在 乙醚 、 乙基溴化镁 、 copper(l) chloride 作用下， 生成 5-cyclohex-1-enyl-2-methyl-pent-3-yn-2-ol
  参考文献：
  名称：

  Mondon, Justus Liebigs Annalen der Chemie, 1952, vol. 577, p. 181,196

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(2-丙炔基)环己烷-1-醇 在 potassium hydrogensulfate 、 苯 作用下， 生成 1-丙-2-炔基-环己烯
  参考文献：
  名称：

  Mondon, Justus Liebigs Annalen der Chemie, 1952, vol. 577, p. 181,196

  摘要：

  DOI：

文献信息

• Copper-Catalyzed Oxidative Alkynylation of Diaryl Imines with Terminal Alkynes: A Facile Synthesis of Ynimines
  作者：Anouar Laouiti、Mohamed M. Rammah、Mohamed B. Rammah、Jérome Marrot、François Couty、Gwilherm Evano

  DOI：10.1021/ol2032152

  日期：2012.1.6

  An efficient copper-mediated method for the oxidative alkynylation of diaryl imines with terminal alkynes is reported. This reaction provides the first catalytic and general synthesis of ynimines and allows for an easy preparation of these useful building blocks. An improved copper-catalyzed oxidative dimerization of imines to azines and the synthesis of dienes and azadienes from ynimines are also

  报道了一种有效的铜介导的方法，用于将二芳基亚胺与末端炔烃进行氧化炔基反应。该反应提供了亚胺的第一催化和一般合成，并允许容易地制备这些有用的结构单元。还描述了改进的铜催化的亚胺向嗪的氧化二聚反应以及由二亚胺合成二烯和氮杂二烯的方法。
• Isoxazolodihydropyridinones: 1,3-Dipolar Cycloaddition of Nitrile Oxides onto 2,4-Dioxopiperidines
  作者：Keith C. Coffman、Timothy P. Hartley、Jerry L. Dallas、Mark J. Kurth

  DOI：10.1021/co200200u

  日期：2012.4.9

  Practical and efficient methods have been developed for the diversity-oriented synthesis of isoxazolodihydropyridinones via the 1,3-dipolar cycloaddition of nitrile oxides onto 2,4-dioxopiperidines. A select few of these isoxazolodihydropyridinones were further elaborated with triazoles by copper-catalyzed azide-alkyne cycloaddition reactions. A total of 70 compounds and intermediates were synthesized and analyzed for drug likeness. Sixty-four of these novel compounds were submitted to the NIH Molecular Libraries Small Molecule Repository for high-throughput biological screening.
• Highly Site- and Enantioselective Cu-Catalyzed Allylic Alkylation Reactions with Easily Accessible Vinylaluminum Reagents
  作者：Yunmi Lee、Katsuhiro Akiyama、Dennis G. Gillingham、M. Kevin Brown、Amir H. Hoveyda

  DOI：10.1021/ja0782192

  日期：2008.1.1

  An efficient method for catalytic asymmetric allylic alkylation (AAA) of allylic phosphates with vinylaluminum reagents is reported. The vinylmetal reagents are prepared by reaction of commercially available DIBAL-H and a terminal alkyne. The resulting vinylaluminum reagent can be used directy, without isolation or purification. AAA reactions are promoted in the presence of 0.5-2.5 mol % of a readily available chiral N-heterocyclic carbene (NHC) complex and 1-5 mol % commercially available and air stable Cu salt (CUCl2-2H(2)O). The desired products are typically obtained within 2-12 h in 74% to 95% isolated yield, 77% to >98% ee, and in >98% E selectivity: >98% S(N)2' selectively is obtained in all but one instance (90%). The hydroalummation/catalytic AAA sequence can be performed in a single vessel, on gram scale.
• Mondon, Justus Liebigs Annalen der Chemie, 1952, vol. 577, p. 181,196
  作者：Mondon

  DOI：——

  日期：——