(E)-4-(4-dimethylaminostyryl)quinoline | 40317-65-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (E)-4-(4-dimethylaminostyryl)quinoline
• 英文别名: 4-(p-N,N-dimethylaminostyryl)quinoline；4-(4-dimethylaminostyryl)quinoline；DMAQ；N,N-dimethyl-4-(2-quinolin-4-yl-vinyl)-aniline；4-(trans-2-[4]quinolyl-vinyl)-N,N-dimethyl-aniline；4-(trans-2-[4]Chinolyl-vinyl)-N,N-dimethyl-anilin；N,N-dimethyl-4-[(E)-2-quinolin-4-ylethenyl]aniline
• CAS: 40317-65-5
• 化学式: C₁₉H₁₈N₂
• 分子量: 274.365
• InChiKey: CIXDQQGMRYRUQA-JXMROGBWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

ADMET

毒理性

• 非人类毒性摘录

...在老鼠中具有致白内障性，单次静脉注射0.1毫克/千克后，首次在八十七天可检测到晶状体混浊。在形态学上，这些白内障与辐射引起的白内障无法区分，但它们倾向于从晶状体的前极开始，而不是后极。

...IS CATARACTOGENIC IN MICE, CAUSING LENS OPACITIES FIRST DETECTABLE EIGHTY-SEVEN DAYS AFTER SINGLE INTRAVENOUS INJECTION OF 0.1 MG/KG. MORPHOLOGICALLY THE CATARACTS BECOME INDISTINGUISHABLE FROM RADIATION-INDUCED CATARACTS, BUT THEY TEND TO START AT THE ANTERIOR POLE OF LENS RATHER THAN AT THE POSTERIOR.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

通过胃管给药的方式，给雄性和雌性大鼠喂食4-(4-二甲氨基苯乙烯基)喹啉，剂量从300倍的范围不等，每周进行5次，一年总共进行了260个单独剂量。据报道，这肯定具有致癌性。

ADMINISTRATION BY GAVAGE OF 4-(4-DIMETHYLAMINOSTYRYL)QUINOLINE @ SEVERAL DOSE LEVELS RANGING 300-FOLD TO MALE & FEMALE RATS WAS PERFORMED 5 TIMES PER WK FOR TOTAL OF 260 INDIVIDUAL DOSES IN 1 YEAR. REPORTED TO DEFINITELY BE CARCINOGENIC.

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为反应物：
  描述：

  (E)-4-(4-dimethylaminostyryl)quinoline 在 碘 作用下， 以 环己烷 为溶剂， 反应 48.0h， 以18%的产率得到N,N-dimethylbenzo[i]phenanthridin-3-amine
  参考文献：
  名称：

  二氢吲哚并二氮杂苯的光致变色反应第七部分：带有取代的苯并[i]菲啶作为发荧光基团的新型光致变色二氢吲哚并二氮杂苯的光化学特性†

  摘要：

  通过顺-反取代的4-苯乙烯基喹啉的光环化以低至中等的产率制备了十六种苯并[i]菲啶衍生物8a-p。通过光谱和分析工具明确阐明了光环化苯并[i]菲啶衍生物的化学结构。该光致变色（PC）dihydroindolizines（DHIs）8A-P基于苯并[d]是在19-57％的收率通过亲核加成苯并[I]菲啶制备菲啶4A-P到spirocyclopropenes 5。一维，二维，NOESY NMR光谱，质谱和元素分析用于表征新合成的DHI 8a-p的化学结构。已经实现了通过基础部分中的取代基开发和调节合成化合物的光物理性质。最大吸收（λ最大）和半衰期（吨1/2有色两性离子形式的）图7a-P在所有情况下由闪光光解测量检测由于快速1,5- electrocyclization回DHI系统。在CH 2 Cl 2溶液中用多色光照射DHI 8a-p会导致在用液氮冷却后形成绿色到绿色-蓝色的甜菜碱7a-p。从甜菜碱7a-p到DHI

  DOI：

  10.1002/poc.1209
• 作为产物：
  描述：

  4-甲基喹啉 、 对二甲氨基苯甲醛 在 zinc(II) chloride 作用下， 生成 (E)-4-(4-dimethylaminostyryl)quinoline
  参考文献：
  名称：

  喹啉系列研究；4-苯乙烯基喹啉的一些衍生物。

  摘要：

  DOI：

  10.1021/ja01211a072

文献信息

• Photochromism of dihydroindolizines. Part II-Synthesis and photophysical properties of new photochromic IR-sensitive photoswitchable substituted fluorene-9′-styrylquinolinedihydroindolizines
  作者：Saleh Abdel-Mgeed Ahmed

  DOI：10.1002/poc.509

  日期：2002.7

  Twenty-nine new photochromic 2,4,7-substituted fluorene-9′-styrylquinolinedihydroindolizines (DHIs) 4a–χ were prepared in 45–75% yield via nucleophilic addition of 4-styrylquinolines 2a–k to substituted spirocyclopropenes 1a–c. The absorption maxima (λmax) of the colored betaines 3a–χ were detected by flash photolysis measurements. All betaines 3a–χ showed two absorption maxima, one in the visible

  通过向取代的螺环丙烯1a-c中亲核加成4-苯乙烯基喹啉2a-k，以45-75％的收率制备了29种新的2,4,7-光致变色的2,9,4-芴基苯乙烯基喹啉二氢吲哚吲哚（DHIs）4a-χ。彩色甜菜碱3a–χ的吸收最大值（λmax）通过快速光解法检测。所有甜菜碱3a-χ均显示出两个吸收最大值，一个在可见光区域（450-525 nm），另一个在红外光区域（825-950 nm）。在低温（77 K）下，通过FT-UV-Vis-Near-IR光谱记录了甜菜碱3a-χ的吸收光谱。甜菜碱3a–χ快速环化过程的动力学通过毫秒快速光解法研究了DHIs4a -χ对DHI的影响，发现发生在毫秒范围内（二氯甲烷溶液中35-310毫秒，甲醇溶液中50-425毫秒）。使用激光闪光光解法测量的瞬态寿命（约1毫秒）归因于（Z）到（E）-甜菜碱3的转化。在吸收最大值（λ大溶剂化变色效果最大）和半衰期的大幅增加（吨1/2与be
• METHOD FOR PRODUCING ORGANIC COMPOUND
  申请人：DAIKIN INDUSTRIES, LTD.

  公开号：US20210371391A1

  公开（公告）日：2021-12-02

  An object of the present disclosure is to provide a method for producing an organic compound, and a composition. The object is achieved by a method for producing a compound represented by formula (1): wherein X represents —O—, an optionally substituted imino group, or —S—, R 1 represents a hydrogen atom or a hydrocarbyl group optionally having at least one substituent, and R 2 represents a hydrogen atom or a monovalent organic group, or R 1 and R 2 , together with X and one carbon atom respectively adjacent to R 1 and R 2 , may form a heterocyclic ring optionally having at least one substituent, R 3 represents a hydrogen atom or a monovalent organic group, and R 4 represents —CF 2 CH 3 or —CH 2 CHF 2 ; the method including step A of reacting a compound represented by formula (2): wherein the alphabetical symbols are as defined above, with vinylidene fluoride under light irradiation.

  本公开的目的是提供一种生产有机化合物和组合物的方法。该目的通过以下公式（1）所表示的化合物的生产方法实现：其中，X表示—O—、可选择置换的亚胺基团或—S—，R1表示氢原子或可选择具有至少一个取代基的碳氢基团，R2表示氢原子或一价有机基团，或R1和R2分别与X和与R1和R2相邻的一个碳原子形成一个杂环环，该杂环环可选择具有至少一个取代基，R3表示氢原子或一价有机基团，R4表示—CF2CH3或—CH2CHF2；该方法包括步骤A，与乙烯基氟在光照射下反应所示的化合物（2）：其中，字母符号如上所定义。
• Photosensitive resin composition and photosensitive films and laminates made by using the same
  申请人：——

  公开号：US20040265731A1

  公开（公告）日：2004-12-30

  A photosensitive resin composition of the present invention contains a (A) soluble polyimide and a (b) (meth)acrylic compound, the (A) soluble polyimide being soluble in an organic solvent and being synthesized by using an acid dianhydride component and at least one of a diamine component containing a siloxane structure or an aromatic ring structure, and a diamine component having, in its structure, a hydroxyl group a carboxyl group or a carbonyl group, and the (B) (meth)acrylic compound having at least one carbon-carbon double bond, and preferably contains at least one of a (C) photo reaction initiator and a (D) fire retardant. With this arrangement, the photosensitive resin composition of the present invention is capable of having excellent properties. Especially, the photosensitive resin composition of the present invention is so excellently useful that it can be used for electronic parts and the like.

  本发明的光敏树脂组合物包含(A)可溶性聚酰亚胺和(b)(甲基)丙烯酸化合物，其中(A)可溶性聚酰亚胺可在有机溶剂中溶解，并通过使用酸性二酐组分和至少一种含有硅氧烷结构或芳香环结构的二胺组分以及结构中具有羟基、羧基或羰基的二胺组分合成，(B)(甲基)丙烯酸化合物具有至少一个碳-碳双键，并且最好包含至少一个(C)光反应引发剂和(D)阻燃剂。通过这种安排，本发明的光敏树脂组合物具有优异的性能。特别是，本发明的光敏树脂组合物非常有用，可以用于电子零件等。
• Photosensitive resin composition capable of being developed with aqueous developer and photosensitive dry film resist, and use thereof
  申请人：Okada Koji

  公开号：US20060199920A1

  公开（公告）日：2006-09-07

  A photosensitive resin composition according to the present invention includes at least a base resin component (A) and a (meth)acryls compound (B), wherein the base resin component (A) is any one of: a polyimide resin (A-1) having at least either a hydroxyl group or a carboxyl group in its structure; a polyamide resin (A-2) having at least either a hydroxyl group or a carboxyl group in its structure; and photosensitive imide(meth)acrylsiloxaneoligomer (A-3). On this account, it is possible to realize characteristics such as (1) realization and improvement of water system developing property, (2) improvement of utility as an imidized film, (3) improvement of post-curing property, and (4) simplification of manufacture of a print wiring substrate. Thus, the photosensitive resin composition can be favorably used particularly in a photosensitive dry film resin, a laminate using the same, a print wiring substrate using the same, and the like.

  本发明提供的一种光敏树脂组合物包括至少一种基础树脂组分(A)和一种（甲基）丙烯酸化合物(B)，其中基础树脂组分(A)是以下任何一种：具有至少一个羟基或羧基的聚酰亚胺树脂(A-1)；具有至少一个羟基或羧基的聚酰胺树脂(A-2)；和光敏亚胺（甲基）丙烯酰基硅氧烷低聚物(A-3)。因此，可以实现特性，例如(1)实现和改善水系开发性能，(2)改善作为亚胺化膜的实用性，(3)改善后固化性能，以及(4)简化印刷线路基板的制造。因此，该光敏树脂组合物可以特别有利地用于光敏干膜树脂、使用相同的层压板、使用相同的印刷线路基板等。
• Photo-sensitive polymer composition
  申请人：HITACHI, LTD.

  公开号：EP0475086A1

  公开（公告）日：1992-03-18

  A photo-sensitive polymer composition comprising (a) a polymer obtained by reacting a poly(amic acid) with one or more amino compounds having at least one hydroxyl group and an isocyanate compound, and (b) one or more photosensitizers, photoinitiators or photocrosslinkers can provide a polyimide film excellent in heat resistance and mechanical properties and is suitable for forming fine patterns.

  一种光敏聚合物组合物由以下部分组成：(a) 聚（氨基）酸与一种或多种具有至少一个羟基的氨基化合物和异氰酸酯化合物反应得到的聚合物；(b) 一种或多种光敏剂、光引发剂或光交联剂。