3-(3,4-dimethoxyphenyl)-1-[4-[4-[4-[3-(3,4-dimethoxyphenyl)prop-2-enoyl]phenoxy]butoxy]phenyl]prop-2-en-1-one | 312488-78-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 3-(3,4-dimethoxyphenyl)-1-[4-[4-[4-[3-(3,4-dimethoxyphenyl)prop-2-enoyl]phenoxy]butoxy]phenyl]prop-2-en-1-one
• CAS: 312488-78-1
• 化学式: C₃₈H₃₈O₈
• 分子量: 622.715
• InChiKey: KDSOEZCSQBGUFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.75
• 重原子数：
  46.0
• 可旋转键数：
  17.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  89.52
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  1,3-二甲基-6-氨基脲嘧啶 、 3-(3,4-dimethoxyphenyl)-1-[4-[4-[4-[3-(3,4-dimethoxyphenyl)prop-2-enoyl]phenoxy]butoxy]phenyl]prop-2-en-1-one 在 sodium ethanolate 作用下， 生成
  参考文献：
  名称：

  oxygenated chalcones and bischalcones as potential antimalarial agents

  摘要：

  Oxygenated chalcones (3a,b) and bischalcones (4a-j) have been synthesized and evaluated for antimalarial activity against chloroquine sensitive and resistant strains of Plasmodium berghei in mice. Some of the screened compounds, 3a, 4c, 4e, 4f and 4i, have shown significant activity st 100 mg/kg dose against sensitive strain. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00409-1
• 作为产物：
  描述：

  对羟基苯乙酮 在 氢氧化钾 、 potassium carbonate 作用下， 以 乙醇 、 丙酮 为溶剂， 生成 3-(3,4-dimethoxyphenyl)-1-[4-[4-[4-[3-(3,4-dimethoxyphenyl)prop-2-enoyl]phenoxy]butoxy]phenyl]prop-2-en-1-one
  参考文献：
  名称：

  oxygenated chalcones and bischalcones as potential antimalarial agents

  摘要：

  Oxygenated chalcones (3a,b) and bischalcones (4a-j) have been synthesized and evaluated for antimalarial activity against chloroquine sensitive and resistant strains of Plasmodium berghei in mice. Some of the screened compounds, 3a, 4c, 4e, 4f and 4i, have shown significant activity st 100 mg/kg dose against sensitive strain. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00409-1

文献信息

• Oxygenated chalcones and bischalcones as a new class of inhibitors of DNA topoisomerase II of malarial parasites
  作者：Shalini Srivastava、Shweta Joshi、Alok R. Singh、Sarika Yadav、A. S. Saxena、V. J. Ram、Subhash Chandra、J. K. Saxena

  DOI：10.1007/s00044-007-9057-0

  日期：2008.6

  correlated with their in vivo antimalarial activity, as compounds 2c and 2h inhibited both in vitro activity of topo II and in vivo parasitaemia of the chloroquine-sensitive strain of P. berghei . In the chloroquine-resistant strain, compounds 2c , 2e , 2g , and 2i inhibited activity against both in vitro topo II and parasitaemia in vivo. The significant inhibition of topo II in the chloroquine-resistant

  啮齿动物疟疾寄生虫 伯氏疟原虫 的氯喹敏感和氯喹抗性菌株的DNA拓扑异构酶（topo）II 被用作测试抗疟化合物的靶标。属于比沙可康和查耳酮系列的化合物显着抑制了 伯氏疟原虫 对氯喹敏感和耐氯喹菌株的酶活性和寄生虫百分率 。化合物 1a ， 1b ， 2a ， 2b 和 2c 表现出100％的抑制作用，而化合物 2h 和 2i 分别显示出对氯喹敏感菌株的拓扑异构酶II活性的抑制作用分别为60％和63％。化合物 2a ， 2b 和 2d 显着抑制了耐氯喹菌株的topo II活性。化合物 2g 和 2e 特异性地抑制了 伯氏疟原虫 的耐氯喹菌株的topo II活性，而对氯 喹敏感菌株没有影响。查尔酮和比沙可康类似物的体外topo II抑制作用与其体内抗疟活性有关，如化合物 2c 和 2h 抑制topo II的体外活性和对 P. berghei 的氯喹敏感菌株的体内寄生虫血症 。在抗氯喹菌株中，化合物
• oxygenated chalcones and bischalcones as potential antimalarial agents
  作者：Vishnu J Ram、Abhishek S Saxena、Shalini Srivastava、Subhash Chandra

  DOI：10.1016/s0960-894x(00)00409-1

  日期：2000.10

  Oxygenated chalcones (3a,b) and bischalcones (4a-j) have been synthesized and evaluated for antimalarial activity against chloroquine sensitive and resistant strains of Plasmodium berghei in mice. Some of the screened compounds, 3a, 4c, 4e, 4f and 4i, have shown significant activity st 100 mg/kg dose against sensitive strain. (C) 2000 Elsevier Science Ltd. All rights reserved.