(E)-ethyl 3-(5-chloro-2-methoxyphenyl)acrylate | 105475-30-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-ethyl 3-(5-chloro-2-methoxyphenyl)acrylate
• 英文别名: 5-chloro-2-methoxy-trans-cinnamic acid ethyl ester；5-Chlor-2-methoxy-trans-zimtsaeure-aethylester；Ethyl 5-chloro-2-methoxycinnamate；3-(5-Chloro-2-methoxy-phenyl)-acrylic acid ethyl ester；ethyl (E)-3-(5-chloro-2-methoxyphenyl)prop-2-enoate
• CAS: 105475-30-7
• 化学式: C₁₂H₁₃ClO₃
• mdl: MFCD10566147
• 分子量: 240.686
• InChiKey: MGRJQUCUJRLOAS-QPJJXVBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (E)-ethyl 3-(5-chloro-2-methoxyphenyl)acrylate 在 氢氧化钾 作用下， 生成 (E)-3-(5-chloro-2-methoxyphenyl)-acrylic acid
  参考文献：
  名称：

  Herniation through both Winslow’s foramen and a lesser omental defect: Report of a case

  摘要：

  The herniation of small bowel through Winslow's foramen is a rare type of internal hernia which ran cause ileus; however, a hernia traversing the lesser sac is even more unusual. To the best of our knowledge, only 25 cases of herniation through Winslow's foramen and 10 cases of lesser sac hernia have been reported in the Japanese literature. We describe herein the case of a 33-year-old man who presented to our hospital complaining of abdominal pain in whom a plain abdominal radiograph revealed small bowel gas with air-fluid levels, suggesting ileus. Following admission, an ileus tube was inserted, but the intestinal shadow did not improve and surgery was performed based on suspicion of an internal hernia. Approximately 100 cm of ileum was found to have herniated through a defect in the lesser omentum after passing through Winslow's foramen, Since the herniated bowel was viable, manual reduction without resection was performed. The patient had a satisfactory postoperative course, and was discharged on postoperative day 11, There are many unknown aspects surrounding the etiology of Winslow's foramen hernia and lesser sac hernia, and although internal hernia is a rare cause of ileus, its possibility should be kept in mind.

  DOI：

  10.1007/s005950070125
• 作为产物：
  描述：

  5-氯-2-甲氧基苯甲醛 在 吡啶 、 氯化亚砜 、 乙醚 、 锌 、 苯 作用下， 生成 (E)-ethyl 3-(5-chloro-2-methoxyphenyl)acrylate
  参考文献：
  名称：

  Herniation through both Winslow’s foramen and a lesser omental defect: Report of a case

  摘要：

  The herniation of small bowel through Winslow's foramen is a rare type of internal hernia which ran cause ileus; however, a hernia traversing the lesser sac is even more unusual. To the best of our knowledge, only 25 cases of herniation through Winslow's foramen and 10 cases of lesser sac hernia have been reported in the Japanese literature. We describe herein the case of a 33-year-old man who presented to our hospital complaining of abdominal pain in whom a plain abdominal radiograph revealed small bowel gas with air-fluid levels, suggesting ileus. Following admission, an ileus tube was inserted, but the intestinal shadow did not improve and surgery was performed based on suspicion of an internal hernia. Approximately 100 cm of ileum was found to have herniated through a defect in the lesser omentum after passing through Winslow's foramen, Since the herniated bowel was viable, manual reduction without resection was performed. The patient had a satisfactory postoperative course, and was discharged on postoperative day 11, There are many unknown aspects surrounding the etiology of Winslow's foramen hernia and lesser sac hernia, and although internal hernia is a rare cause of ileus, its possibility should be kept in mind.

  DOI：

  10.1007/s005950070125

文献信息

• Air-Stable Solid Aryl and Heteroaryl Organozinc Pivalates: Syntheses and Applications in Organic Synthesis
  作者：Sophia M. Manolikakes、Mario Ellwart、Christos I. Stathakis、Paul Knochel

  DOI：10.1002/chem.201403015

  日期：2014.9.15

  air‐stable, solid, polyfunctional aryl and heteroarylzinc pivalates were efficiently prepared by either magnesium insertion or Hal/Mg exchange followed by transmetalation with Zn(OPiv)2 (OPiv=pivalate). By reducing the amount of LiCl the air stability could be significantly enhanced compared with previously prepared reagents. An alternative route is directed magnesiation using TMPMgCl⋅LiCl (TMP=2,2,6,6‐

  通过插入镁或Hal / Mg交换，然后用Zn（OPiv）2（OPiv =新戊酸酯）进行金属转移，可以有效地制备各种空气稳定的固体多官能芳基和杂芳基锌新戊酸酯。与以前制备的试剂相比，通过减少LiCl的含量，可以显着提高空气稳定性。的替代路线是使用TMPMgCl涉及镁化⋅的LiCl（TMP = 2,2,6,6-四甲基），然后用锌（OPiv）转移金属化2，或者对于非常敏感的底物，直接浸锌通过使用TMPZnOPiv。这些锌试剂不仅对空气具有极好的稳定性，而且它们的C范围也很广。C键形成反应，例如烯丙基化和碳环化反应，以及醛的加成和1,4加成反应。可以通过使用过量的TMSC1来克服无所不在的新戊酸酯阴离子的副反应来进行酰化反应。
• Cinnamoylaminoalkyl-substituted benzenesulfonamide derivatives, processes for their preparation, their use, and pharmaceutical preparations comprising them
  申请人：Aventis Pharma Deutschland GmbH

  公开号：US06350778B1

  公开（公告）日：2002-02-26

  The present invention relates to cinnamoylaminoalkyl-substituted benzenesulfonamide derivatives of formula I in which A(1), A(2), A(3), R(1), R(2), R(3), R(4), X, Y, and Z have the meanings indicated in the claims. Compounds of formula I are valuable pharmaceutical active compounds which exhibit, for example, an inhibitory action on ATP-sensitive potassium channels in the cardiac muscle and/or in the cardiac nerve and are suitable, for example, for the treatment of disorders of the cardiovascular system such as coronary heart disease, arrhythmias, cardiac insufficiency or cardiomyopathies, or for the prevention of sudden cardiac death, or for improving decreased contractility of the heart. The invention furthermore relates to processes for the preparation of compounds of formula I, their use, and pharmaceutical preparations comprising them.

  本发明涉及公式I的肉桂酰氨基烷基取代的苯磺酰胺衍生物 其中A(1)，A(2)，A(3)，R(1)，R(2)，R(3)，R(4)，X，Y和Z的含义如权利要求所述。公式I的化合物是有价值的药物活性化合物，例如，对心脏肌肉和/或心脏神经中的ATP敏感钾通道具有抑制作用，例如，适用于治疗心血管系统疾病，如冠心病，心律失常，心功能不全或心肌病，或预防心脏猝死，或改善心脏收缩功能降低。本发明还涉及制备公式I化合物的方法，其用途以及包含它们的药物制剂。
• BF₃·OEt₂-mediated syn-selective Meyer–Schuster rearrangement of phenoxy propargyl alcohols for Z-β-aryl-α,β-unsaturated esters
  作者：Surendra Puri、Madala Hari Babu、Maddi Sridhar Reddy

  DOI：10.1039/c6ob01090c

  日期：——

  1-aryl-3-phenoxy propargyl alcohols is achieved via a BF3-mediated syn-selective Meyer–Schuster rearrangement under ambient conditions. The reaction mechanism is postulated to involve an electrophilic borylation of an allene intermediate as the key step to kinetically control the stereoselectivity.

  通过在环境条件下通过BF 3介导的顺选择性Meyer-Schuster重排，可以从容易获得的1-芳基-3-苯氧基炔丙基醇合成Z -β-芳基-α，β-不饱和酯。假定该反应机理涉及丙二烯中间体的亲电子硼化，这是动力学控制立体选择性的关键步骤。
• CINNAMOYLAMINOALKYL-SUBSTITUTED BENZENESULFONAMIDE DERIVATIVES
  申请人：Aventis Pharma Deutschland GmbH

  公开号：EP1183236A1

  公开（公告）日：2002-03-06
• US6350778B1
  申请人：——

  公开号：US6350778B1

  公开（公告）日：2002-02-26