7-chloro-4-(5-methoxy-2-methylanilino)-6-nitro-3-quinolinecarbonitrile | 348617-42-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-chloro-4-(5-methoxy-2-methylanilino)-6-nitro-3-quinolinecarbonitrile
• 英文别名: 7-chloro-4-(5-methoxy-2-methylanilino)-6-nitroquinoline-3-carbonitrile
• CAS: 348617-42-5
• 化学式: C₁₈H₁₃ClN₄O₃
• 分子量: 368.779
• InChiKey: QDSYLGILUCJIEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  104
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  7-chloro-4-(5-methoxy-2-methylanilino)-6-nitro-3-quinolinecarbonitrile 在 palladium on activated charcoal sodium azide 、 氢气 作用下， 生成 6,7-diamino-4-(5-methoxy-2-methylanilino)-3-quinolinecarbonitrile
  参考文献：
  名称：

  8-Anilinoimidazo[4,5-g]quinoline-7-carbonitriles as Src Kinase Inhibitors

  摘要：

  A series of 8-anilinoimidazo[4,5-g]quinoline-7-carbonitriles was synthesized and evaluated as Src kinase inhibitors. Several aniline substituents were surveyed, as well as water-solubilizing groups at the C-2 and N-3 positions. Potent Src inhibitors were identified, with N-3 providing the best position for an additional water-solubilizing group. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00524-3
• 作为产物：
  描述：

  3-氯-4-硝基苯胺 在 sodium hydroxide 、 三聚氯氰 、 草酰氯 、 吡啶盐酸盐 、 N,N'-羰基二咪唑 作用下， 以 乙二醇乙醚 、 N,N-二甲基甲酰胺 为溶剂， 生成 7-chloro-4-(5-methoxy-2-methylanilino)-6-nitro-3-quinolinecarbonitrile
  参考文献：
  名称：

  8-Anilinoimidazo[4,5-g]quinoline-7-carbonitriles as Src Kinase Inhibitors

  摘要：

  A series of 8-anilinoimidazo[4,5-g]quinoline-7-carbonitriles was synthesized and evaluated as Src kinase inhibitors. Several aniline substituents were surveyed, as well as water-solubilizing groups at the C-2 and N-3 positions. Potent Src inhibitors were identified, with N-3 providing the best position for an additional water-solubilizing group. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00524-3

文献信息

• Tricyclic protein kinase inhibitors
  申请人：American Home Products Corporation

  公开号：US20010051620A1

  公开（公告）日：2001-12-13

  This invention provides compounds of formula 1, having the structure 1 which are useful as inhibitors of protein tyro sine kinase and are antiproliferative agents.

  这项发明提供了具有结构1的化合物，这些化合物可作为蛋白酪氨酸激酶的抑制剂，是抗增殖剂。
• [EN] TRICYCLIC PROTEIN KINASE INHIBITORS<br/>[FR] INHIBITEURS TRICYCLIQUES DE PROTEINE KINASE
  申请人：AMERICAN HOME PROD

  公开号：WO2001047892A1

  公开（公告）日：2001-07-05

  This invention provides compounds of formula (1) which are useful as inhibitors of protein tyrosine kinase and are antiproliferative agents.

  本发明提供了一种式子为(1)的化合物，它们可用作蛋白酪氨酸激酶的抑制剂并具有抗增殖作用。
• TRICYCLIC PROTEIN KINASE INHIBITORS
  申请人：Wyeth

  公开号：EP1242382A1

  公开（公告）日：2002-09-25
• US6638929B2
  申请人：——

  公开号：US6638929B2

  公开（公告）日：2003-10-28
• US7105531B2
  申请人：——

  公开号：US7105531B2

  公开（公告）日：2006-09-12