8-(2,2-Dimethyl-propionyloxy)-quinoline-2,7-dicarboxylic acid 7-tert-butyl ester | 717132-01-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-(2,2-Dimethyl-propionyloxy)-quinoline-2,7-dicarboxylic acid 7-tert-butyl ester
• CAS: 717132-01-9
• 化学式: C₂₀H₂₃NO₆
• 分子量: 373.406
• InChiKey: NBZOVMWVQZADSH-UHFFFAOYSA-N

物化性质

• 沸点：
  495.2±40.0 °C(predicted)
• 密度：
  1.228±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.84
• 重原子数：
  27.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  102.79
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  8-(2,2-Dimethyl-propionyloxy)-quinoline-2,7-dicarboxylic acid 7-tert-butyl ester 在 sodium azide 、 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Linker-modified quinoline derivatives targeting HIV-1 integrase: synthesis and biological activity

  摘要：

  A novel series of HIV-1 integrase inhibitors was synthesized and tested in both in vitro and ex vivo assays. These inhibitors are featured by the presence of a quinoline subunit and an ancillary aromatic ring linked by functionalized spacers such as amide, hydrazide, urea and 1-hydroxyprop-l-en-3-one moiety. Amide derivatives are the most promising ones and could serve as leads for further developments. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.03.005
• 作为产物：
  描述：

  8-Hydroxy-2-methyl-quinoline-7-carboxylic acid 2,2,2-trichloro-ethyl ester 在 吡啶 、 selenium(IV) oxide 作用下， 以 四氢呋喃 、 吡啶 为溶剂， 生成 8-(2,2-Dimethyl-propionyloxy)-quinoline-2,7-dicarboxylic acid 7-tert-butyl ester
  参考文献：
  名称：

  Linker-modified quinoline derivatives targeting HIV-1 integrase: synthesis and biological activity

  摘要：

  A novel series of HIV-1 integrase inhibitors was synthesized and tested in both in vitro and ex vivo assays. These inhibitors are featured by the presence of a quinoline subunit and an ancillary aromatic ring linked by functionalized spacers such as amide, hydrazide, urea and 1-hydroxyprop-l-en-3-one moiety. Amide derivatives are the most promising ones and could serve as leads for further developments. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.03.005