2-(p-tolyloxy)-6-methoxy-3-(5-(pyridin-4-yl)-1,3,4 oxadiazol-2yl)quinoline | 1326717-81-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(p-tolyloxy)-6-methoxy-3-(5-(pyridin-4-yl)-1,3,4 oxadiazol-2yl)quinoline
• 英文别名: 2-[8-Methoxy-2-(4-methylphenoxy)quinolin-3-yl]-5-pyridin-4-yl-1,3,4-oxadiazole
• CAS: 1326717-81-0
• 化学式: C₂₄H₁₈N₄O₃
• 分子量: 410.432
• InChiKey: NSABAPUEPXJVPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  83.2
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  对甲酚 在 碘 、 potassium carbonate 、 溶剂黄146 作用下， 以 乙醇 、 二甲基亚砜 、 N,N-二甲基甲酰胺 为溶剂， 生成 2-(p-tolyloxy)-6-methoxy-3-(5-(pyridin-4-yl)-1,3,4 oxadiazol-2yl)quinoline
  参考文献：
  名称：

  Synthesis and antibacterial activity of novel series of 2-(p-tolyloxy)-3-(5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl)quinoline

  摘要：

  AbstractA new series of 2‐(p‐tolyloxy)‐3‐(5‐(pyridin‐4‐yl)‐1,3,4‐oxadiazol‐2‐yl)quinoline were synthesized from oxidative cyclization of N′‐((2‐(p‐tolyloxy)quinoline‐3‐yl)methylene)isonicotinohydrazide in DMSO/I2 at reflux condition for 3–4 h. The structures of the new compounds were confirmed by elemental analyses as well as IR, 1H‐NMR, and mass spectral data. All the synthesized compounds were screened for their antibacterial activities against various bacterial strains. Several of these compounds showed potential antibacterial activity. J. Heterocyclic Chem., (2011).

  DOI：

  10.1002/jhet.653