丙氨酸谷氨酸盐 | 13187-90-1

• 物质功能分类: 生物化工 - 氨基酸及其衍生物 - 谷氨酸类衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 丙氨酸谷氨酸盐
• 中文别名: L-丙氨酰-L-谷氨酸
• 英文名称: H-Ala-Glu-OH
• 英文别名: Ala-Glu；L-alanyl-L-glutamic acid；Alanine glutamate；(2S)-2-[[(2S)-2-aminopropanoyl]amino]pentanedioic acid
• CAS: 13187-90-1
• 化学式: C₈H₁₄N₂O₅
• 分子量: 218.21
• InChiKey: VYZAGTDAHUIRQA-WHFBIAKZSA-N

物化性质

• 沸点：
  520.5±50.0 °C(Predicted)
• 密度：
  1.362±0.06 g/cm3(Predicted)
• LogP：
  -2.330 (est)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -3.8
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  130
• 氢给体数：
  4
• 氢受体数：
  6

安全信息

• 海关编码：
  2924199090
• 危险性防范说明：
  P233,P260,P261,P264,P270,P271,P280,P301+P312,P302+P352,P304,P304+P340,P305+P351+P338,P312,P321,P330,P332+P313,P337+P313,P340,P362,P403,P403+P233,P405,P501
• 危险性描述：
  H315,H319,H335

反应信息

• 作为反应物：
  描述：

  丙氨酸谷氨酸盐 在 substituted Grubbs-type ruthenium carbene complex 盐酸 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 生成 dimethyl (2S)-2-[[(2S)-2-[[(E)-4-[(2R,3S,4R,5S,6R)-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-yl]but-2-enoyl]amino]propanoyl]amino]pentanedioate
  参考文献：
  名称：

  Cross‐metathesis ofC‐Glycosides and Peptides

  摘要：

  Peptides bearing an acryloyl residue at their N-terminus were coupled with various C-glycosides in an equimolar ratio via cross-metathesis. The newly formed olefin was obtained with high E/Z selectivity in satisfying to high yields with low homodimerization of the starting materials. The posttranslational cross-metathesis approach was shown to be suitable for the combinatorial synthesis of a small library of C-glycopeptides.

  DOI：

  10.1080/00397910701481146
• 作为产物：
  描述：

  N-[(苄氧基)羰基]-L-丙氨酰-L-谷氨酰胺 生成 丙氨酸谷氨酸盐
  参考文献：
  名称：

  STEHLE, P.;MONTER, B.;BAHSITTA, H. P.;FURST, P., J. LIQUID CHROMATOGR., 12,(1989) N4, C. 2821-2838

  摘要：

  DOI：

文献信息

• The .GAMMA.-phenacyl and .GAMMA.-p-nitrobenzyl esters to minimize side reactions during treatment of glutamyl peptides with hydrogen fluoride-anisole mixture.
  作者：KENJI SUZUKI、NOBUYOSHI ENDO、YUSUKE SASAKI

  DOI：10.1248/cpb.25.2613

  日期：——

  For the synthesis of peptide containing glutamic acid residue (s) by solid phase peptide synthesis, γ-phenacyl or γ-nitrobenzyl ester group, which is stable to anhydrous hydrogen fluoride (HF), was used as γ-carboxyl protecting group of glutamic acid to minimize the side reactions. The protected peptide resins were treated with HF-anisole mixture followed by deprotection of the γ-carboxyl protecting group under mild conditions. This strategy gave a satisfactory result without detectable side reactions in the preparations of two model dipeptides, H-Ala-Glu-OH and H-Asn-Glu-OH, by solid phase peptide synthesis.

  为了通过固相肽合成合成含有谷氨酸残基的肽，采用了对无水氟化氢（HF）稳定的γ-苯乙酰或γ-硝基苯基酯基团作为谷氨酸的γ-羧基保护基团，以最小化副反应。保护后的肽树脂用HF-乙醚混合物处理，然后在温和条件下去除γ-羧基保护基团。这一策略在合成两个模型二肽H-Ala-Glu-OH和H-Asn-Glu-OH时取得了令人满意的结果，未检测到副反应。
• Stereochemical aspects in the synthesis of novel N-(purin-6-yl)dipeptides as potential antimycobacterial agents
  作者：Vera V. Musiyak、Irina A. Nizova、Evgeny N. Chulakov、Liliya Sh. Sadretdinova、Andrey A. Tumashov、Galina L. Levit、Victor P. Krasnov

  DOI：10.1007/s00726-021-02958-0

  日期：2021.3

  The synthesis of purine conjugates with natural amino acids is one of the promising directions in search for novel therapeutic agents, including antimycobacterial agents. The purpose of this study was to synthesize N-(purin-6-yl)dipeptides containing the terminal fragment of (S)-glutamic acid. To obtain the target compounds, two synthetic routes were tested. The first of them is based on coupling of

  嘌呤缀合物与天然氨基酸的合成是寻找新型治疗剂（包括抗分枝杆菌剂）的有希望的方向之一。本研究的目的是合成含有( S )-谷氨酸末端片段的N- (purin-6-yl)二肽。为了获得目标化合物，测试了两种合成路线。其中第一个是基于在碳二亚胺偶联剂存在下将 N-(purin - 6-yl)-( S )-氨基酸与 (S)-谷氨酸二甲酯偶联，然后去除酯基。然而，事实证明，这种偶联过程伴随着N的手性中心的消旋化。-(purin-6-yl)-α-氨基酸，在所有情况下都会产生 ( S,S )- 和 ( R,S )-非对映异构体 (6:4) 的混合物。使用基于氯在 6-氯嘌呤或 2-氨基-6-氯嘌呤中的亲核取代以及相应的二肽作为亲核试剂的替代方法获得单个 ( S,S )-非对映异构体。目标化合物的对映体纯度通过手性 HPLC 确认。为了检验N- (purin-6-yl)-α-氨基酸的手性中心消旋化发生在咪唑
• Peptide-forming enzyme gene, peptide-forming enzyme, and peptide producing method
  申请人：Tonouchi Naoto

  公开号：US20050037453A1

  公开（公告）日：2005-02-17

  The present invention provides a method for producing dipeptide using inexpensively acquirable starting materials by an industrially advantageous and simple pathway. Dipeptide is produced from L-amino acid ester and L-amino acid using a culture of microbes having the ability to produce a dipeptide from an L-amino acid ester and an L-amino acid, using microbial cells isolated from the culture, or a treated microbial cell product of the microbe.

  本发明提供了一种使用成本低廉的起始材料通过工业上有利且简单的途径生产二肽的方法。通过使用具有从L-氨基酸酯和L-氨基酸生产二肽的能力的微生物培养物，使用从培养物中分离出的微生物细胞或经处理的微生物细胞产物，从L-氨基酸酯和L-氨基酸生产二肽。
• Process for producing dipeptide,l-amino acid amide hydrolase to be used therein and process for producing l-amino acid amide hydrolase
  申请人：Nozaki Hiroyuki

  公开号：US20050054067A1

  公开（公告）日：2005-03-10

  A process for industrially advantageously producing a dipeptide via a convenient pathway starting with less expensive and easily available materials is provided. A dipeptide is produced from an L-amino acid amide and an L-amino acid by using a culture of a microbe capable of synthesizing the dipeptide from the L-amino acid amide and the L-amino acid, microbial cells separated from the culture or a treated microbial cell product from the microbe. An L-amino acid amide hydrolase is obtained from a microbe belonging to the genus erwinia, genus Rhodococcus, genus Chryseobacterium, genus Micrococcus, genus Cryptococcus, genus Trichosporion, genus Rhodosporidium, genus Sporobolomyces, genus Tremela, genus Torulaspora, genus Sterigmatomyces or genus Rhodotorula. The hydrolase catalyzes a reaction that produces a dipeptide from an L-amino acid amide and an L-amino acid.

  提供一种工业上优势的方法，通过一个便捷的途径，使用成本较低且易得的材料开始，生产二肽。通过使用能够从L-氨基酸酰胺和L-氨基酸合成二肽的微生物培养物，从培养物中分离的微生物细胞或经过处理的微生物细胞产物来制备二肽。从属于Erwinia属，Rhodococcus属，Chryseobacterium属，Micrococcus属，Cryptococcus属，Trichosporion属，Rhodosporidium属，Sporobolomyces属，Tremela属，Torulaspora属，Sterigmatomyces属或Rhodotorula属的微生物中获得L-氨基酸酰胺水解酶。该水解酶催化从L-氨基酸酰胺和L-氨基酸产生二肽的反应。
• MUTANT PROTEIN HAVING THE PEPTIDE-SYNTHESIZING ACTIVITY
  申请人：ABE Isao

  公开号：US20070292916A1

  公开（公告）日：2007-12-20

  The present invention aims at providing an excellent peptide-synthesizing protein and a method for efficiently producing a peptide. The peptide is synthesized by reacting an amine component and a carboxy component in the presence of at least one of proteins shown in the following (I) and (II). (I) The mutant protein having an amino acid sequence comprising one or more mutations from any of the mutations 1 to 68, and the mutations 239 to 290 and 324 to 377 in an amino acid sequence of SEQ ID NO:2. (II) The mutant protein having an amino acid sequence comprising one or more mutations from any of the mutations L1 to L335 and M1 to M642 in an amino acid sequence of SEQ ID NO:208

  本发明旨在提供一种优秀的肽合成蛋白质及高效生产肽的方法。在以下（I）和（II）所示的蛋白质的至少一种存在下，通过在胺组分和羧组分存在下反应合成肽。其中，（I）为突变蛋白质，其氨基酸序列包括来自于突变1至突变68、突变239至突变290和突变324至突变377的一个或多个突变；（II）为突变蛋白质，其氨基酸序列包括来自于L1至L335和M1至M642的一个或多个突变。

表征谱图