(3R,8aalpha)-2,3,4,7,8,8a-六氢-4beta-羟基-8beta-(羟基甲基)-8alpha-甲基-1H-3aalpha,7alpha-甲桥薁-3beta,6-二甲酸 | 4448-95-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: (3R,8aalpha)-2,3,4,7,8,8a-六氢-4beta-羟基-8beta-(羟基甲基)-8alpha-甲基-1H-3aalpha,7alpha-甲桥薁-3beta,6-二甲酸
• 英文名称: (8aS)-4c-hydroxy-8t-methyl-8c-hydroxymethyl-(8arH)-1.2.4.7.8.8a-hexahydro-3H-3at.7t-methano-azulene-dicarboxylic acid-(3c.6)
• 英文别名: (8aS)-4c-Hydroxy-8t-methyl-8c-hydroxymethyl-(8arH)-1.2.4.7.8.8a-hexahydro-3H-3at.7t-methano-azulen-dicarbonsaeure-(3c.6)；Schellolsaeure；Shellolic acid；Shellolsaeure；(1S,2R,5S,6S,7R,10S)-10-hydroxy-6-(hydroxymethyl)-6-methyltricyclo[5.3.1.01,5]undec-8-ene-2,8-dicarboxylic acid
• CAS: 4448-95-7
• 化学式: C₁₅H₂₀O₆
• 分子量: 296.32
• InChiKey: WSASFFHWOQGSER-MUAIWGBPSA-N

物化性质

• 熔点：
  204-207°

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  115
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (3R,8aalpha)-2,3,4,7,8,8a-六氢-4beta-羟基-8beta-(羟基甲基)-8alpha-甲基-1H-3aalpha,7alpha-甲桥薁-3beta,6-二甲酸 在 potassium permanganate 、 硫酸 作用下， 生成 (3aS)-3a-methyl-1-oxo-(3ar,3bt,7ac)-octahydro-pentaleno[1,2-c]furan-6t,6at-dicarboxylic acid dimethyl ester
  参考文献：
  名称：

  Nagel; Mertens, Chemische Berichte, 1939, vol. 72, p. 985,990

  摘要：

  DOI：

文献信息

• Shellolic acid and Epi-shellolic acid
  作者：R.C. Cookson、N. Lewin、A. Morrison

  DOI：10.1016/s0040-4020(01)92705-x

  日期：1962.1

  Saturation of the double bond in shellolic acid by hydrogenation, hydroxylation or bromination results in the formation of δ- and γ-lactones, the further reactions of which are discussed in the light of the structure for the acid recently established by Yates and Field. The diol from reaction with osmium tetroxide is degraded by periodate to an aldehyde with three less carbon atoms. The ester group

  通过氢化，羟基化或溴化作用使Shellolic acid中的双键饱和，会形成δ-和γ-内酯，并根据Yates and Field最近建立的酸结构对它们的进一步反应进行了讨论。与四氧化反应产生的二醇被高碘酸盐降解为碳原子数少三个的醛。该醛中的酯基和甲壳酸二甲酯中的相应仲酯基及其另一种氧化产物可被碱差向异构化。
• COATED IMPLANT
  申请人：Schömig Albert

  公开号：US20100158974A1

  公开（公告）日：2010-06-24

  The present invention relates to an implant or part thereof coated with a wax or a resin. Especially, the present invention relates to an implant or part thereof coated with shellac.

  本发明涉及一种涂有蜡或树脂的植入物或其部件。特别地，本发明涉及一种涂有虫胶的植入物或其部件。
• SUSTAINED RELEASE FORMULATIONS OF CURCUMINOIDS AND METHOD OF PREPARATION THEREOF
  申请人：Arjuna Natural Extracts, Ltd.

  公开号：US20160067300A1

  公开（公告）日：2016-03-10

  A sustained release curcuminoid composition having a bioavailable curcumin composition and a release rate controlling excipient. The bioavailable composition of curcumin includes a curcuminoid mixture and an added essential oil of turmeric. The curcuminoid mixture includes curcumin, demethoxycurcumin and bisdemethoxycurcumin. The added essential oil of turmeric includes about 40% to about 50% of ar-turmerone. Methods of preparing sustained release compositions having a bioavailable curcumin composition and a release rate controlling excipient.

  一种具有生物可利用的姜黄素组合物和释放速率控制助剂的持续释放姜黄素组合物，其中生物可利用的姜黄素组合物包括姜黄素混合物和添加的姜黄精油。姜黄素混合物包括姜黄素，去甲氧基姜黄素和双去甲氧基姜黄素。添加的姜黄精油包括大约40％至50％的ar-姜黄烯。制备具有生物可利用的姜黄素组合物和释放速率控制助剂的持续释放组合物的方法。
• POWDER COATING, METHOD FOR PRODUCTION THEREOF, METHOD FOR USING SAID POWDER COATING AND COATED ARTICLE
  申请人：Kansai Paint Co., Ltd.

  公开号：EP1561787A1

  公开（公告）日：2005-08-10

  The present invention provides a powder paint excellent in productivity and cost, because the powder paints that are not adhered to the substrate can recovered and reused. And in case of using the powder paint of the present invention, coating efficiency is high and fine textured coated films excellent in attractiveness of appearance and water resistance can be obtained, because the base paint powder and the pigment particle thereof hardly separate. The powder paints of the present invention are characterized in that the pigment particles are bound to the base paint powders via shellac. The powder paints of the present invention not only allow uniform and firm binding of pigment particles to base paint powders by the action of shellac, but also provide the resulting coated films with excellent attractiveness of appearance.

  本发明提供的粉末涂料生产效率高、成本低，因为未附着在基材上的粉末涂料可以回收和重复使用。在使用本发明的粉末涂料时，由于基底涂料粉末和其中的颜料颗粒几乎不分离，因此涂布效率高，可获得外观吸引力和耐水性极佳的质地细腻的涂膜。本发明粉末涂料的特点是颜料颗粒通过虫胶与底漆粉末结合在一起。本发明的粉末涂料不仅能在虫胶的作用下使颜料颗粒与底漆粉末均匀牢固地结合在一起，还能使涂膜具有极佳的外观吸引力。
• WATER-BASED SHELLAC COATING MATERIAL, PROCESS FOR PRODUCING THE SAME, COATED FOOD OBTAINED WITH THE COATING MATERIAL, PROCESS FOR PRODUCING THE SAME, COATED MEDICINE, PROCESS FOR PRODUCING THE SAME, GLAZING COMPOSITION FOR OILY SNACK, METHOD OF GLAZING, AND GLAZED OILY SNACK
  申请人：Freund Corporation

  公开号：EP1579771A1

  公开（公告）日：2005-09-28

  There are provided an aqueous shellac coating agent comprising shellac, a basic amino acid and/or a basic phosphate, as well as a production process therefor; a coated food and a coated drug that have been coated with such a coating agent; a glazing composition for oil-based confectionary which is in a liquid form and comprises an aqueous shellac solution (A) containing shellac, a basic amino acid and/or a basic phosphate dissolved in water, a thickener (B), and/or a sugar (C); a process for glazing oil-based confectionary in which this glazing composition is applied to oil-based confectionary to be glazed, thereby generating a glaze; and glazed oil-based confectionary produced using this process for glazing oil-based confectionary.

  本发明提供了一种由虫胶、碱性氨基酸和/或碱性磷酸组成的虫胶水溶液涂布剂及其生产工艺；一种用这种涂布剂涂布的涂布食品和涂布药物；一种用于油基糖果的上光组合物，该组合物为液态，由虫胶水溶液（A）、增稠剂（B）和/或糖（C）组成，其中虫胶水溶液（A）含有溶于水的虫胶、碱性氨基酸和/或碱性磷酸，增稠剂（B）和/或糖（C）；一种给油基糖果上釉的工艺，在该工艺中，将这种上釉组合物涂在要上釉的油基糖果上，从而产生釉；以及使用这种给油基糖果上釉的工艺生产的上釉油基糖果。