N3,N5-bis((S)-1-hydroxy-3-methylbutan-2-yl)-4-phenyl-1H-pyrazole-3,5-dicarboxamide | 1207950-68-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N3,N5-bis((S)-1-hydroxy-3-methylbutan-2-yl)-4-phenyl-1H-pyrazole-3,5-dicarboxamide
• CAS: 1207950-68-2
• 化学式: C₂₁H₃₀N₄O₄
• 分子量: 402.494
• InChiKey: MBFHFOZFSFQFDI-HZPDHXFCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.57
• 重原子数：
  29.0
• 可旋转键数：
  9.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  127.34
• 氢给体数：
  5.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  N3,N5-bis((S)-1-hydroxy-3-methylbutan-2-yl)-4-phenyl-1H-pyrazole-3,5-dicarboxamide 在 氯化亚砜 、 sodium methylate 作用下， 以 1,2-二氯乙烷 、 甲醇 为溶剂， 反应 7.0h， 以58%的产率得到3,5-bis((S)-4-isopropyl-4,5-dihydro-2-oxazolyl)-1H-4-phenylpyrazole
  参考文献：
  名称：

  Dinuclear Allylpalladium Complexes ofC₂-Symmetric Pyrazolate-Bridged Bis(oxazoline) Ligands (pyrbox's): Structures, Dynamic Behavior, and Application in Asymmetric Allylic Alkylation

  摘要：

  A series of new chiral binucleating pyrazolate-based N-donor ligands (3a-d) with oxazoline side arms (coined pyrbox's) have been synthesized. Bimetallic methallylpalladium complexes (4a-d) of these ligands were obtained, and the solid-state structures of complexes 4a,c were characterized by X-ray diffraction. NMR spectroscopy revealed that in solution 4a-d exist as three different isomers that differ in the orientation of the two methallyl ligands. Exchange between the isomers (i.e., allyl rotation) was observed in two-dimensional NOESY NMR experiments as syn/syn and anti/anti interconversion of the allylic hydrogen atoms; kinetic parameters for the fluxional behavior have been determined. The catalytic activity of the complexes was tested in palladium-catalyzed allylic alkylation of rac-(E)-1,3-diphenylallyl acetate. By comparison of the set of complexes 4a-d that feature different ligand scaffolds, both steric and electronic factors were found to be important for enantiocontrol, and a model has been proposed for rationalizing the observed enantioselectivities.

  DOI：

  10.1021/om900835f
• 作为产物：
  描述：

  L-缬氨醇 、 4-phenyl-1H-pyrazole-3,5-dicarboxylic acid dimethyl ester 在 三氟甲磺酸 作用下， 以 甲醇 为溶剂， 反应 72.0h， 以73%的产率得到N3,N5-bis((S)-1-hydroxy-3-methylbutan-2-yl)-4-phenyl-1H-pyrazole-3,5-dicarboxamide
  参考文献：
  名称：

  Dinuclear Allylpalladium Complexes ofC₂-Symmetric Pyrazolate-Bridged Bis(oxazoline) Ligands (pyrbox's): Structures, Dynamic Behavior, and Application in Asymmetric Allylic Alkylation

  摘要：

  A series of new chiral binucleating pyrazolate-based N-donor ligands (3a-d) with oxazoline side arms (coined pyrbox's) have been synthesized. Bimetallic methallylpalladium complexes (4a-d) of these ligands were obtained, and the solid-state structures of complexes 4a,c were characterized by X-ray diffraction. NMR spectroscopy revealed that in solution 4a-d exist as three different isomers that differ in the orientation of the two methallyl ligands. Exchange between the isomers (i.e., allyl rotation) was observed in two-dimensional NOESY NMR experiments as syn/syn and anti/anti interconversion of the allylic hydrogen atoms; kinetic parameters for the fluxional behavior have been determined. The catalytic activity of the complexes was tested in palladium-catalyzed allylic alkylation of rac-(E)-1,3-diphenylallyl acetate. By comparison of the set of complexes 4a-d that feature different ligand scaffolds, both steric and electronic factors were found to be important for enantiocontrol, and a model has been proposed for rationalizing the observed enantioselectivities.

  DOI：

  10.1021/om900835f