Methyl 2-(4-chlorobenzoyl)-2-(hydroxymethyl)propanoate | 131825-43-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Methyl 2-(4-chlorobenzoyl)-2-(hydroxymethyl)propanoate
• 英文别名: methyl 2-methyl-2-hydroxymethyl-3-(4-chlorophenyl)-3-keto-propanoate；methyl 3-(4-chlorophenyl)-2-(hydroxymethyl)-2-methyl-3-oxopropanoate
• CAS: 131825-43-9
• 化学式: C₁₂H₁₃ClO₄
• 分子量: 256.686
• InChiKey: LNEDCSACIDUSAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Methyl 2-(4-chlorobenzoyl)-2-(hydroxymethyl)propanoate 在 sodium acetate 、 一水合肼 、 溶剂黄146 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 、 甲苯 为溶剂， 反应 10.0h， 生成 methyl 5-(4-chlorophenyl)-2-[(4-methoxyphenyl)carbamoyl]-4-methyl-3H-pyrazole-4-carboxylate
  参考文献：
  名称：

  Quantitative structure-activity relationships of insecticidal pyrazolines

  摘要：

  AbstractMethyl 3‐(4‐chlorophenyl)‐4‐methyl‐1‐[N‐(4‐substituted pheny1)carba‐moy1]‐2‐pyrazoline‐4‐carboxylates and related compounds were prepared. Their convulsant activity was determined as the minimum dose required to bring about the symptom within 1 h after injection against male adult American cockroaches, Periplaneta americana (L.). Insecticidal activity with metabolic inhibitors for oxidation and hydrolysis was measured 24 h after injection of the test compounds. Variations in each of the activities were analysed by using physicochemical substituent parameters and regression analysis. The findings indicated that the greater the hydrophobicity and the more the electron‐withdrawing property of the substituents, the higher were the activities. Variations in each of the two activities were parabolically related to the STERIMOL width parameter with an optimum value of about zero.

  DOI：

  10.1002/ps.2780420406
• 作为产物：
  描述：

  4-氯苯丙酮 在 吡啶 、 苄基三甲基氢氧化铵 、 sodium hydride 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 2.0h， 生成 Methyl 2-(4-chlorobenzoyl)-2-(hydroxymethyl)propanoate
  参考文献：
  名称：

  Quantitative structure-activity relationships of insecticidal pyrazolines

  摘要：

  AbstractMethyl 3‐(4‐chlorophenyl)‐4‐methyl‐1‐[N‐(4‐substituted pheny1)carba‐moy1]‐2‐pyrazoline‐4‐carboxylates and related compounds were prepared. Their convulsant activity was determined as the minimum dose required to bring about the symptom within 1 h after injection against male adult American cockroaches, Periplaneta americana (L.). Insecticidal activity with metabolic inhibitors for oxidation and hydrolysis was measured 24 h after injection of the test compounds. Variations in each of the activities were analysed by using physicochemical substituent parameters and regression analysis. The findings indicated that the greater the hydrophobicity and the more the electron‐withdrawing property of the substituents, the higher were the activities. Variations in each of the two activities were parabolically related to the STERIMOL width parameter with an optimum value of about zero.

  DOI：

  10.1002/ps.2780420406
• 作为试剂：
  描述：

  methyl 3-(4-chlorophenyl)-2-methyl-3-oxopropanoate 、 聚合甲醛 、 吡啶 、 盐酸 在 ice 、 Brine 、 magnesium sulfate 、 Methyl 2-(4-chlorobenzoyl)-2-(hydroxymethyl)propanoate 作用下， 以 甲醇 、 乙醚 为溶剂， 反应 2.0h， 以affords 1100 g (100%) of a red oil, methyl 2-methyl-2-hydroxymethyl-3-(4-chlorophenyl)-3-keto-propanoate的产率得到Methyl 2-(4-chlorobenzoyl)-2-(hydroxymethyl)propanoate
  参考文献：
  名称：

  N-aryl-3-aryl-4,5-dihydro-1H-pyrazole-1-carboxamides and methods of

  摘要：

  本发明涉及一种新型的N-芳基-3-芳基-4,5-二氢-1H-吡唑-1-羧酰胺化合物，其作为杀虫剂有用，包含这些化合物的组合物，控制害虫的方法和制备这些化合物的方法。

  公开号：

  US04863947A1

文献信息

• US4863947A
  申请人：——

  公开号：US4863947A

  公开（公告）日：1989-09-05
• Quantitative structure-activity relationships of insecticidal pyrazolines
  作者：Riaz Hasan、Keiichiro Nishimura、Tamio Ueno

  DOI：10.1002/ps.2780420406

  日期：1994.12

  AbstractMethyl 3‐(4‐chlorophenyl)‐4‐methyl‐1‐[N‐(4‐substituted pheny1)carba‐moy1]‐2‐pyrazoline‐4‐carboxylates and related compounds were prepared. Their convulsant activity was determined as the minimum dose required to bring about the symptom within 1 h after injection against male adult American cockroaches, Periplaneta americana (L.). Insecticidal activity with metabolic inhibitors for oxidation and hydrolysis was measured 24 h after injection of the test compounds. Variations in each of the activities were analysed by using physicochemical substituent parameters and regression analysis. The findings indicated that the greater the hydrophobicity and the more the electron‐withdrawing property of the substituents, the higher were the activities. Variations in each of the two activities were parabolically related to the STERIMOL width parameter with an optimum value of about zero.
• N-aryl-3-aryl-4,5-dihydro-1H-pyrazole-1-carboxamides and methods of
  申请人：Rohm and Haas

  公开号：US04863947A1

  公开（公告）日：1989-09-05

  This invention relates to novel N-aryl-3-aryl-4,5-dihydro-1H-pyrazole-1-carboxamide compounds which are useful as pesticides, compositions containing those compounds, methods of controlling pests and processes for preparing these compounds.

  本发明涉及新颖的N-芳基-3-芳基-4,5-二氢-1H-吡唑-1-甲酰胺化合物，这些化合物作为农药具有实用性，包含这些化合物的组合物，控制害虫的方法以及制备这些化合物的工艺。