3-(2-methoxy-4-pyridyl)propionaldehyde | 119836-18-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(2-methoxy-4-pyridyl)propionaldehyde
• 英文别名: 3-(2-Methoxypyridin-4-YL)propanal
• CAS: 119836-18-9
• 化学式: C₉H₁₁NO₂
• mdl: MFCD10698165
• 分子量: 165.192
• InChiKey: KRBMEEQXJRBMAK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(2-methoxy-4-pyridyl)propionaldehyde 在 potassium permanganate 、 硫酸 、 甲基三辛基氯化铵 作用下， 以 丙酮 为溶剂， 反应 6.0h， 生成 3-(2-甲氧基-4-吡啶基)丙酸甲酯
  参考文献：
  名称：

  Adger, Brian M.; Ayrey, Peter; Bannister, Robin, Journal of the Chemical Society. Perkin transactions I, 1988, p. 2791 - 2796

  摘要：

  DOI：
• 作为产物：
  描述：

  2-溴-4-甲基吡啶 在 sodium amide 作用下， 以 水 、 溶剂黄146 、 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 生成 3-(2-methoxy-4-pyridyl)propionaldehyde
  参考文献：
  名称：

  Adger, Brian M.; Ayrey, Peter; Bannister, Robin, Journal of the Chemical Society. Perkin transactions I, 1988, p. 2791 - 2796

  摘要：

  DOI：

文献信息

• Synthesis and evaluation of 8-amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives as glycogen synthase kinase-3 (GSK-3) inhibitors
  作者：Kwangwoo Chun、Ji-Seon Park、Han-Chang Lee、Young-Ha Kim、In-Hea Ye、Kang-Jeon Kim、Il-Whea Ku、Min-Young Noh、Goang-Won Cho、Heejaung Kim、Seung Hyun Kim、Jeongmin Kim

  DOI：10.1016/j.bmcl.2013.03.119

  日期：2013.7

  New potent glycogen synthase kinase-3 (GSK-3) inhibitors, 8-amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives, were designed by modeling, synthesized and evaluated in vitro. Compound 17c showed good potency in enzyme and cell-based assays (IC50 = 111 nM, EC50 = 1.78 μM). Moreover, it has demonstrated desirable water solubility, PK profile, and moderate brain penetration.

  通过建模，合成设计了新的强力糖原合酶激酶3（GSK-3）抑制剂8-氨基-[1,2,4]三唑并[4,3 - a ]吡啶-3（2 H）-one衍生物。并进行了体外评价。化合物17c在基于酶和细胞的测定中显示出良好的效价（IC 50  = 111 nM，EC 50  = 1.78μM）。此外，已证明其具有理想的水溶性，PK曲线和适度的大脑渗透能力。
• Bi-functional complexes and methods for making and using such complexes
  申请人：Gouliaev Alex Haahr

  公开号：US11225655B2

  公开（公告）日：2022-01-18

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

  本发明涉及一种合成双功能复合物的方法，该复合物包括分子部分和识别分子部分的识别寡核苷酸部分。根据本发明的合成方法的一部分优选在一种或多种有机溶剂中进行，此时包含可选保护标签或寡核苷酸标识符的新生双功能复合物与固体支持物相连接，合成方法的另一部分优选在适合于将寡核苷酸标签酶加到溶液中的新生双功能复合物的条件下进行。
• ADGER, BRIAN M.;AYREY, PETER;BANNISTER, ROBIN;FORTH, MICHAEL A.;HAJIKARIM+, J. CHEM. SOC. PERKIN TRANS. PT 1,(1988) N 10, C. 2791-2796
  作者：ADGER, BRIAN M.、AYREY, PETER、BANNISTER, ROBIN、FORTH, MICHAEL A.、HAJIKARIM+

  DOI：——

  日期：——
• BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Nuevolution A/S

  公开号：EP2558577A1

  公开（公告）日：2013-02-20
• BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Gouliaev Alex Haahr

  公开号：US20130281324A1

  公开（公告）日：2013-10-24

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.