3-formyl-2-methylcyclopentanone | 116511-18-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-formyl-2-methylcyclopentanone
• 英文别名: 2-Methyl-3-oxocyclopentane-1-carbaldehyde
• CAS: 116511-18-3
• 化学式: C₇H₁₀O₂
• 分子量: 126.155
• InChiKey: PORSLRXAINXJMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-formyl-2-methylcyclopentanone 在 sodium tetrahydroborate 、 三氟甲磺酸 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 为溶剂， 反应 2.5h， 生成 trans-3-benzyloxymethyl-2-methyl cyclopentanone
  参考文献：
  名称：

  A useful application of benzyl trichloroacetimidate for the benzylation of alcohols

  摘要：

  Primary, secondary and tertiary alcohols, which are sensitive under basic or acidic reaction conditions, can be O-benzylated under mild acidic reaction conditions using benzyl 2,2,2-trichloroacetimidate as the benzylation agent. Chiral substrates, which have a tendency towards racemization under basic reaction conditions, can be benzylated without any loss of chirality.

  DOI：

  10.1016/s0040-4020(01)80349-5
• 作为产物：
  描述：

  (2Ξ,3SR)-2-Methyl-3-vinylcyclopentan-1-on 在 二甲基硫 、 氧气 、 臭氧 作用下， 生成 3-formyl-2-methylcyclopentanone
  参考文献：
  名称：

  A useful application of benzyl trichloroacetimidate for the benzylation of alcohols

  摘要：

  Primary, secondary and tertiary alcohols, which are sensitive under basic or acidic reaction conditions, can be O-benzylated under mild acidic reaction conditions using benzyl 2,2,2-trichloroacetimidate as the benzylation agent. Chiral substrates, which have a tendency towards racemization under basic reaction conditions, can be benzylated without any loss of chirality.

  DOI：

  10.1016/s0040-4020(01)80349-5

文献信息

• A useful application of benzyl trichloroacetimidate for the benzylation of alcohols
  作者：Peter Eckenberg、Ulrich Groth、Thomas Huhn、Norbert Richter、Carsten Schmeck

  DOI：10.1016/s0040-4020(01)80349-5

  日期：——

  Primary, secondary and tertiary alcohols, which are sensitive under basic or acidic reaction conditions, can be O-benzylated under mild acidic reaction conditions using benzyl 2,2,2-trichloroacetimidate as the benzylation agent. Chiral substrates, which have a tendency towards racemization under basic reaction conditions, can be benzylated without any loss of chirality.