(E)-16-hydroxy-7-hexadecenoic acid | 88785-32-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-16-hydroxy-7-hexadecenoic acid
• 英文别名: (E)-16-Hydroxy-7-hexadecensaeure；16-hydroxy-E-7-hexadecenoic acid；16-hydroxy-7-hexadecenoic acid；trans-Ambrettolidsaeure；Ambrettolic acid；(E)-16-hydroxyhexadec-7-enoic acid
• CAS: 88785-32-4
• 化学式: C₁₆H₃₀O₃
• 分子量: 270.412
• InChiKey: MKIFOPBVDBXRTO-DUXPYHPUSA-N

物化性质

• 熔点：
  53-54 °C
• 沸点：
  432.2±28.0 °C(Predicted)
• 密度：
  0.971±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  19
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (E)-16-hydroxy-7-hexadecenoic acid 在 三氟化硼乙醚 、 magnesium chloride 作用下， 反应 6.25h， 生成 (E)-oxacycloheptadec-8-en-2-one
  参考文献：
  名称：

  Majee; Chatterjea; Sengupta, Journal of the Indian Chemical Society, 2006, vol. 83, # 11, p. 1179 - 1180

  摘要：

  DOI：
• 作为产物：
  描述：

  Ethoxycarbonyl 6-bromohexanoate 在 Lindlar's catalyst 喹啉 、 氢氧化钾 、 ammonium hydroxide 、 正丁基锂 、 (EtOPO₂)4 、 硫酸 、 水 、 氢气 、 对甲苯磺酸 、 二苯二硫醚 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 甲醇 、 六甲基磷酰三胺 、 乙醚 、 正己烷 、 氯仿 、 环己烷 、 乙酸乙酯 、 丙酮 为溶剂， 反应 12.08h， 生成 (E)-16-hydroxy-7-hexadecenoic acid
  参考文献：
  名称：

  2,4,10-三氧杂正丁基酯二甲酸酯; Verwendung zur Synthese von SubstieriertenCarbonsäurenmit Hilfe von Grignard -Reagenzien

  摘要：

  具有2,4,10-三氧杂金刚烷结构作为羧基保护基的邻苯二甲酸酯; 格氏试剂在取代羧酸合成中的应用。

  DOI：

  10.1002/hlca.19830660741

文献信息

• Anticancer agents, perfumes or foods and drinks containing omega-hydroxyfatty acids
  申请人：——

  公开号：US20030055105A1

  公开（公告）日：2003-03-20

  The present invention relates to drugs and, particularly, to anticancer agents. More particularly, the present invention relates to an anticancer agents containing, as an active ingredient, at least one compound selected from the group consisting of &ohgr;-hydroxy fatty acids and salts or esters thereof, hydroxy oxo-fatty acids and salts or esters thereof, lactones, macrocyclic ketones, and macrocyclic diesters having specific chemical structures. With respect to the compounds described above used in the present invention, since the activities of killing cancer and inhibiting cancer metastasis are significantly high, the effects of preventing the recurrence of cancer and preventing cancer are exhibited, the cytotoxicity is significantly low, and a small dose is effective, it is possible to provide anticancer agents having significantly decreased side effects. Additionally, use in combination with known antitumor agents can further enhance the activity of inhibiting cancer metastasis. Among the anticancer agents of the present invention, &ohgr;-hydroxy fatty acids can be easily obtained in high purities by hydrolyzing lactones which are also the anticancer agents of the present invention.

  本发明涉及药物，特别是抗癌剂。更具体地说，本发明涉及一种抗癌剂，其含有至少一种从以下化合物组合中选择的活性成分，包括ω-羟基脂肪酸及其盐或酯、羟基酮脂肪酸及其盐或酯、内酯、大环酮和具有特定化学结构的大环二酯。对于本发明中所述的上述化合物，由于其杀灭癌细胞和抑制癌转移的活性显著高，具有预防癌症复发和预防癌症的效果，细胞毒性显著低，且小剂量就能发挥作用，因此能够提供具有显著降低副作用的抗癌剂。此外，与已知的抗肿瘤药物结合使用可以进一步增强抑制癌转移的活性。在本发明的抗癌剂中，ω-羟基脂肪酸可以通过水解也是本发明的抗癌剂的内酯轻松获得高纯度。
• Preparation of cis-isoambrettolides and their use as a fragrance
  申请人：V. Mane Fils S.A.

  公开号：US05726328A1

  公开（公告）日：1998-03-10

  A method for the production of .omega.-haloalkyl esters which are useful as intermediates in the synthesis of cis-oxacycloheptadec-11-en-2-one (Product I) and cis-oxacycloheptadec-12-en-2-one (Product II). Also disclosed is a process for the synthesis of Products I-II and a method for using Products I-II to impart an ambery or musky smell to a fragrance composition. Finally, fragrance compositions including Products I-II are disclosed as well as end products such as perfume extracts, toilet waters, cosmetic preparations, soaps, detergents and functional products, each of which also contains at least one of Products I-II.

  本发明涉及一种制备ω-卤代烷基酯的方法，该酯在合成顺-氧杂环庚十七烯-2-酮（产物I）和顺-氧杂环庚十七烯-12-烯-2-酮（产物II）的中间体中有用。还公开了合成产物I-II的过程以及使用产物I-II为香料组合物赋予琥珀或麝香气味的方法。最后，本发明还公开了包括产物I-II的香料组合物以及香水提取物、香水、化妆品制剂、肥皂、洗涤剂和功能性产品等最终产品，每种最终产品中都至少含有产物I-II之一。
• Preparation of cis-isoambrettolidies and their use as a fragrance
  申请人：V. Mane Fils S.A.

  公开号：US05786321A1

  公开（公告）日：1998-07-28

  A method for the production of .omega.-haloalkyl esters which are useful as intermediates in the synthesis of cis-oxacycloheptadec-11-en-2-one (Product I) and cis-oxacycloheptadec-12-en-2-one (Product II). Also disclosed is a process for the synthesis of Products I-II and a method for using Products I-II to impart an ambery or musky smell to a fragrance composition. Finally, fragrance compositions including Products I-II are disclosed as well as end products such as perfume extracts, toilet waters, cosmetic preparations, soaps, detergents and functional products, each of which also contains at least one of Products I-II.

  一种生产ω-卤代烷基酯的方法，该酯在合成顺-氧杂环庚十七烯-2-酮（产物I）和顺-氧杂环庚十七烯-12-2-酮（产物II）的中间体中有用。还公开了合成产物I-II的过程以及使用产物I-II赋予香料组合物琥珀或麝香气味的方法。最后，还公开了包括产物I-II的香料组合物和最终产品，如香水提取物、香水、化妆品制剂、肥皂、洗涤剂和功能性产品，每种产品中都至少含有产物I-II之一。
• THERMOPLASTIC COMPOSITION CONTAINING A MOLD RELEASE AGENT WHICH IS BASED ON AN ESTER OF DI- OR POLYGLYCEROLS AND AT LEAST ONE CARBOXYLIC ACID
  申请人：Daute Peter

  公开号：US20100267860A1

  公开（公告）日：2010-10-21

  The present invention relates to a thermoplastic composition containing a thermoplastic polymer, a mold release agent, and optionally further additives, wherein the mold release agent contains an ester of at least one alcohol component based on two or more glycerol units, and at least one carboxylic acid or a derivative of a carboxylic acid or both. The present invention also relates to a method for producing a thermoplastic composition, to the thermoplastic composition obtainable by this method, to a method for producing a molded article based on a thermoplastic composition, to a molded article obtainable by this method and also to the use of a mold release agent.

  本发明涉及一种热塑性组合物，包含热塑性聚合物、模具脱模剂和可选的进一步添加剂，其中模具脱模剂包含基于两个或多个甘油单元的至少一种醇组分的酯，以及至少一种羧酸或羧酸衍生物或两者都有。本发明还涉及一种制备热塑性组合物的方法，以及由该方法获得的热塑性组合物、一种基于热塑性组合物制备成型品的方法、由该方法获得的成型品，以及模具脱模剂的使用。
• Crystalline polyolefin composition
  申请人：Chisso Corporation

  公开号：EP0416321A1

  公开（公告）日：1991-03-13

  A crystalline polyolefin composition which provides molded articles having improved stiffness characteristics is disclosed, comprising 100 parts by weight of a crystalline polyolefin, (A) from 0.001 to 1 part by weight of a fluorophosphite compound represented by formula (I): wherein R represents an alkylidene group having from 1 to 4 carbon atoms or a sulfur atom; Ar1 and Ar2, which may be the same or different, each represents an alkylarylene group or a cycloalkylarylene group; and n represents 0 or 1, and (B) from 0.001 to 1 part by weight of at least one compound selected from the group consisting of (1) an aliphatic monocarboxylic acid salt with lithium or sodium, (2) a dithiocarbamic acid salt with lithium, sodium or potassium, (3) a 2-mercaptobenzothiazole salt with lithium, sodium or potassium, (4) a 2-mercaptobenzimidazole salt with lithium, sodium or potassium and (5) a benzotriazole salt with lithium, sodium or potassium. A crystalline polyolefin composition which provides molded articles having improved stiffness charateristics is also disclosed, comprising 100 parts by weight of a crystalline polyolefin, (A) from 0.001 to 1 part by weight of a fluorophosphite compound represented by formula (I) shown above, (B ) from 0.001 to 1 part by weight of at least one compound selected from the group consisting of (1) an aliphatic monocarboxylic acid salt with potassium, strontium or barium, (2) a hydroxy-higher fatty acid salt with potassium, strontium or barium, (3) an aliphatic polycarboxylic acid salt with lithium, sodium, potassium, strontium or barium, (4) a salt of an aliphatic hydroxy acid having form 2 to 6 carbon atoms with lithium, sodium, potassium, magnesium, strontium or barium, (5) an aromatic carboxylic acid salt with lithium, sodium, strontium, barium or aluminum, (6) a glutamic acid salt with lithium, sodium, potassium, strontium or barium, (7) an aliphatic phosphoric acid salt with sodium, potassium, calcium, strontium or barium, (8) a lithium, sodium, potassium or barium salt of a cyclic phosphorus compound represented by formula (II): wherein Ar3 and Ar4, which may be the same or different, each represents an arylene group, an alkylarylene group, a cycloalkylarylene group, an arylarylene group or an aralkylarylene group; M represents lithium, sodium, potassium or barium; and m represents an atomic valence of M, (9) magnesium or aluminum hydroxide, (10) magnesium oxide, (11) magnesium or calcium carbonate and (12) hydrotalcite, and (C) from 0.01 to 1 part by weight of an aliphatic amine.

  本发明公开了一种结晶聚烯烃组合物，该组合物可提供具有改进的刚度特性的模塑制品，该组合物包括按重量计100份的结晶聚烯烃、(A)按重量计0.001至1份的由式(I)代表的亚磷酸氟化合物： 其中 R 代表具有 1 至 4 个碳原子的亚烷基或硫原子；Ar1 和 Ar2 可以相同或不同，各自代表烷基芳基或环烷基芳基；n 代表 0 或 1，以及 (B) 0.(1) 锂或钠的脂肪族一羧酸盐，(2) 锂、钠或钾的二硫代氨基甲酸盐、(3) 锂、钠或钾的 2-巯基苯并噻唑盐， (4) 锂、钠或钾的 2-巯基苯并咪唑盐， (5) 锂、钠或钾的苯并三唑盐。 本发明还公开了一种结晶聚烯烃组合物，该组合物可提供具有改进的刚度特性的模塑制品，其成分包括 100 份（重量）结晶聚烯烃、(A) 0.001 至 1 份（重量）由上文式(I)代表的亚磷酸氟化合物、(B ) 0.(1)钾、锶或钡的脂肪族一羧酸盐；(2)钾、锶或钡的羟基高级脂肪酸盐；(3)锂、钠、钾、锶或钡的脂肪族多羧酸盐；(4)锂、钠、钾、镁、锶或钡的具有 2 至 6 个碳原子的脂肪族羟基酸盐、(5) 锂、钠、锶、钡或铝的芳香族羧酸盐； (6) 锂、钠、钾、锶或钡的谷氨酸盐、(7) 含有钠、钾、钙、锶或钡的脂肪族磷酸盐， (8) 由式（II）代表的环磷化合物的锂、钠、钾或钡盐： 其中 Ar3 和 Ar4 可以相同或不同，各自代表芳基、烷芳基、环烷芳基、芳基芳基或芳基芳基；M 代表锂、钠、钾或钡；m 代表 M 的原子价，(9) 氢氧化镁或铝，(10) 氧化镁，(11) 碳酸镁或碳酸钙和 (12) 水滑石，以及 (C) 0.01至1份重量的脂肪族胺。