1-(2-methoxy-[1,1'-biphenyl]-4-yl)ethanone | 56917-30-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2-methoxy-[1,1'-biphenyl]-4-yl)ethanone
• 英文别名: 1-(3-methoxy-4-phenyl)phenylethanone；3'-methoxy-4'-phenylacetophenone；1-(2-Methoxy[1,1a(2)-biphenyl]-4-yl)ethanone；1-(3-methoxy-4-phenylphenyl)ethanone
• CAS: 56917-30-7
• 化学式: C₁₅H₁₄O₂
• 分子量: 226.275
• InChiKey: HUCGHZJCTDHMQE-UHFFFAOYSA-N

物化性质

• 沸点：
  326.7±22.0 °C(Predicted)
• 密度：
  1.076±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(2-methoxy-[1,1'-biphenyl]-4-yl)ethanone 在 palladium on activated charcoal 氢溴酸 、 氢气 作用下， 以 溶剂黄146 、 乙酸乙酯 为溶剂， 生成 4-(1-甲基乙基)[1,1'-联苯]-2-醇
  参考文献：
  名称：

  FR2231393

  摘要：

  公开号：
• 作为产物：
  描述：

  1-(4-溴-3-甲氧基苯基)乙酮 、 苯硼酸 在 bis-triphenylphosphine-palladium(II) chloride 、 caesium carbonate 作用下， 以 1,4-二氧六环 为溶剂， 反应 22.0h， 以98%的产率得到1-(2-methoxy-[1,1'-biphenyl]-4-yl)ethanone
  参考文献：
  名称：

  Structure-Based Approach to the Development of Potent and Selective Inhibitors of Dihydrofolate Reductase from Cryptosporidium

  摘要：

  Cryptosporidiosis is an emerging infectious disease that can be life-threatening in ail immune-compromised individual and causes gastrointestinal distress lasting up to 2 weeks in an immune-competent individual. There are few therapeutics available for effectively treating this disease. We have been exploring dihydrofolate reductase (DHFR) as a potential target in Cryptosporidium. On the basis of the structure of the DHFR enzyme from C. hominis, we have developed a novel scaffold that led to the discovery of potent (38 nM) and efficient inhibitors of this enzyme. Recently, we have advanced these inhibitors to the next stage of development. Using the Structures of both the protozoal and human enzymes. we have developed inhibitors with nanomolar potency (1.1 nM) against the pathogenic enzyme and high levels (1273-fold) of selectivity over the human enzyme.

  DOI：

  10.1021/jm8009124

文献信息

• An efficient palladium–benzimidazolyl phosphine complex for the Suzuki–Miyaura coupling of aryl mesylates: facile ligand synthesis and metal complex characterization
  作者：Kin Ho Chung、Chau Ming So、Shun Man Wong、Chi Him Luk、Zhongyuan Zhou、Chak Po Lau、Fuk Yee Kwong

  DOI：10.1039/c2cc15972d

  日期：——

  A new class of easily accessible hemilabile benzimidazolyl phosphine ligands has been developed. The ligand skeleton is prepared from commercially available and inexpensive o-phenylenediamine and 2-bromobenzoic acid. With catalyst loading down to 0.5 mol% palladium, excellent catalytic activity towards the Suzuki-Miyaura coupling of aryl mesylates is still observed. This represents the lowest catalyst

  已经开发出一种新型的易于获得的半不稳定的苯并咪唑基膦配体。配体骨架由可商购的和廉价的邻苯二胺和2-溴苯甲酸制备。在催化剂负载量低至0.5mol％钯的情况下，仍观察到对甲磺酸甲磺酸酯的Suzuki-Miyaura偶联的优异催化活性。通常，这代表了迄今为止该反应所达到的最低催化剂负载量。X射线晶体学表明，新的配体L2以Kappa（2）-P，N的方式与Pd配合。
• Palladium-catalyzed Buchwald-Hartwig Amination and Suzuki-Miyaura Cross-coupling Reaction of Aryl Mesylates
  作者：Shun Wong

  DOI：10.15227/orgsyn.092.0195

  日期：——
• A General Palladium-Catalyzed Suzuki-Miyaura Coupling of Aryl Mesylates
  作者：Chau Ming So、Chak Po Lau、Fuk Yee Kwong

  DOI：10.1002/anie.200803193

  日期：2008.10.6
• Ligands for transition-metals and methods of use
  申请人：Kwong Fuk Yee

  公开号：US20090326243A1

  公开（公告）日：2009-12-31

  The present invention relates to indolyl phosphine ligands, and methods of making such ligands utilizing phenyl hydrazines and aryl ketones as the starting material. The present invention further includes uses of the ligands in the synthesis of pharmaceuticals, materials, and agriculture.
• US3991212A
  申请人：——

  公开号：US3991212A

  公开（公告）日：1976-11-09