3-(acetoxymethyl)-(1H)-quinol-2-one | 460316-11-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-(acetoxymethyl)-(1H)-quinol-2-one
• 英文别名: 3-acetoxymethylcarbostyril；(2-oxo-1H-quinolin-3-yl)methyl acetate
• CAS: 460316-11-4
• 化学式: C₁₂H₁₁NO₃
• mdl: MFCD07798428
• 分子量: 217.224
• InChiKey: OIBAGZWOPBPXNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(acetoxymethyl)-(1H)-quinol-2-one 在 potassium carbonate 作用下， 以 甲醇 、 水 为溶剂， 反应 1.0h， 以85%的产率得到3-羟甲基-1H-喹啉-2-酮
  参考文献：
  名称：

  Applications of Baylis–Hillman chemistry: one-pot convenient synthesis of functionalized (1H)-quinol-2-ones and quinolines

  摘要：

  A simple synthesis of functionalized (1H)-quinol-2-ones and quinolines from the Baylis-Hillman adducts, i.e. alkyl 3-hydroxy-2-methylene-3-arylpropanoates and beta-hydroxy-alpha-methylene-beta-arylalkanones, respectively, has been described. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)00332-0
• 作为产物：
  描述：

  3-乙酰氧基-2-亚甲基-3-(2-硝基苯基)丙酸甲酯 在 铁粉 作用下， 以 溶剂黄146 为溶剂， 反应 0.5h， 以71%的产率得到3-(acetoxymethyl)-(1H)-quinol-2-one
  参考文献：
  名称：

  Applications of Baylis–Hillman chemistry: one-pot convenient synthesis of functionalized (1H)-quinol-2-ones and quinolines

  摘要：

  A simple synthesis of functionalized (1H)-quinol-2-ones and quinolines from the Baylis-Hillman adducts, i.e. alkyl 3-hydroxy-2-methylene-3-arylpropanoates and beta-hydroxy-alpha-methylene-beta-arylalkanones, respectively, has been described. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)00332-0

文献信息

• Carbostyril derivatives
  申请人：Otsuka Pharmaceutical Co., Ltd.

  公开号：US04578381A1

  公开（公告）日：1986-03-25

  Disclosed are carbostyril derivatives and their salts of the formulas ##STR1## The compounds have anti-peptic ulcer effects, and are useful as a treating agent for curing peptic ulcers in the digestive system, such as ulcers in the stomach and in the duodenum. The compounds particularly have prophylaxis and curing effects for treating chronic ulcers, for example experimental acetic acid-induced ulcers and cautery ulcers, with both low toxicity and few side-effects. Also disclosed are processes for preparing the compounds and for preparing pharmaceutical compositions containing them.

  揭示了化学式为##STR1##的羧基喹啉衍生物及其盐。这些化合物具有抗消化性溃疡作用，并可用作治疗消化系统中的消化性溃疡的治疗剂，例如胃和十二指肠溃疡。这些化合物特别具有预防和治疗慢性溃疡的效果，例如实验性乙酸诱导的溃疡和烧灼性溃疡，具有低毒性和少副作用。还揭示了制备这些化合物以及制备含有它们的药物组合物的方法。
• Grapevine plant named ‘GENSEL 1’
  申请人：Special New Fruit Licensing Mediterráneo S.L. (SNFL Mediterráneo S.L.)

  公开号：USPP034722P2

  公开（公告）日：2022-11-08

  ‘GENSEL 1’ is a new and distinct grapevine plant with novel characteristics that include good fertility and naturally loose bunches, nice and well-structured. The berries produced by ‘GENSEL 1’ are white and seedless with a crisp texture and neutral flavor and no detectable seed traces. The berries produced by ‘GENSEL 1’ are large, weighing 6-7 g/berry on average, and harvested in early September in Murcia Region (Spain).

  ‘GENSEL 1’是一种新的、独特的葡萄树，具有新颖的特性，包括良好的生育力和自然松散的果穗，果实美观结构良好。‘GENSEL 1’所产生的葡萄是白色的无籽果，质地酥脆，味道中性，没有可检测到的籽痕迹。‘GENSEL 1’所产生的葡萄颗粒大，平均每颗重6-7克，在西班牙穆尔西亚地区于9月初收获。
• US4578381A
  申请人：——

  公开号：US4578381A

  公开（公告）日：1986-03-25
• USRE34722E
  申请人：——

  公开号：USRE34722E

  公开（公告）日：1994-09-06
• Applications of Baylis–Hillman chemistry: one-pot convenient synthesis of functionalized (1H)-quinol-2-ones and quinolines
  作者：Deevi Basavaiah、Ravi Mallikarjuna Reddy、Nagaswamy Kumaragurubaran、Duddu S Sharada

  DOI：10.1016/s0040-4020(02)00332-0

  日期：2002.5

  A simple synthesis of functionalized (1H)-quinol-2-ones and quinolines from the Baylis-Hillman adducts, i.e. alkyl 3-hydroxy-2-methylene-3-arylpropanoates and beta-hydroxy-alpha-methylene-beta-arylalkanones, respectively, has been described. (C) 2002 Elsevier Science Ltd. All rights reserved.