1-(1,3-环己二烯-1-基)乙酮 | 53329-13-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-(1,3-环己二烯-1-基)乙酮
• 英文名称: 1-acetyl-1,3-cyclohexadiene
• 英文别名: 1-cyclohexa-1,3-dienyl-ethanone；1-Cyclohexa-1,3-dienyl-aethanon；Δ^1,3-Dihydroacetophenon；1-Acetyl-cyclohexadien-(1,3)；1-(1,3-Cyclohexadien-1-yl)ethanone；1-cyclohexa-1,3-dien-1-ylethanone
• CAS: 53329-13-8
• 化学式: C₈H₁₀O
• 分子量: 122.167
• InChiKey: XFQNQOLPNYVPDT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2914299000

反应信息

• 作为反应物：
  描述：

  1-(1,3-环己二烯-1-基)乙酮 在 <(Bu^t2PH)PdPBu^t2>2 pretreated with O2 、 氢气 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以93%的产率得到乙酰基环已烯
  参考文献：
  名称：

  Selective Hydrogenation of Simple and Functionalized Conjugated Dienes Using a Binuclear Palladium Complex Catalyst Precursor

  摘要：

  DOI：

  10.1016/00404-0399(50)11207-
• 作为产物：
  描述：

  [(1S,6R)-6-acetylcyclohex-2-en-1-yl] ethyl carbonate 在 sodium carbonate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 以87%的产率得到1-(1,3-环己二烯-1-基)乙酮
  参考文献：
  名称：

  O-1-(1,3-butadienyl) carbamates as diels-alder dienes: Stereospecific synthesis of (±)-Hernandulcin and congeners

  摘要：

  DOI：

  10.1016/s0040-4039(00)88818-8

文献信息

• HEPATITIS C VIRUS INHIBITORS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20170320833A1

  公开（公告）日：2017-11-09

  The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

  本公开涉及化合物、组合物和方法，用于治疗丙型肝炎病毒（HCV）感染。还公开了含有这些化合物的制药组合物和使用这些化合物治疗HCV感染的方法。
• Therapeutic morpholino-substituted compounds
  申请人：AstraZeneca AB

  公开号：EP1857443A2

  公开（公告）日：2007-11-21

  Morpholino-substituted pyridopyrimidine, quinolone, and benzopyranone derivatives inhibit phosphoinositide (PI) 3-kinase, an enzyme that regulates platelet-adhesion processes. As a cansequence, the compounds in question have anti-thrombotic activity, as well as other pharmaceutical properties. PI 3-kinase generates 3-phosphorylated PI second messengers which stimulate platelet adhesion under blood-flow conditions. Because platelet adhesion is a necessary step in the formation of a thrombus, inhibition by these compounds of PI 3-kinase under such conditions inhibits or prevents thrombus formation. The compounds are useful in treating PI 3-kinase-dependent conditions including cardiovascular diseases such as coronary artery occlusion, stroke, acute coronary syndrome, acute myocardial infarction, vascular restenasis, atherosclerosis, and unstable angina; respiratory diseases such as asthma, chronic obstructive pulmonary diseases (COPD), and bronchitis; inflammatory disorders; neoplasms including cancers such as glioma, prostate cancer, small cell lung cancer, and breast cancer; and diseases linked to disordered white blood cell function, such as autoimmune and inflammatory diseases.

  吗啉基取代的吡啶嘧啶、喹诺酮和苯并吡喃酮衍生物可抑制磷脂酰肌醇（PI）3-激酶，这是一种调节血小板粘附过程的酶。因此，这些化合物具有抗血栓活性和其他药物特性。PI 3-kinase 生成 3 磷化 PI 第二信使，在血液流动条件下刺激血小板粘附。由于血小板粘附是血栓形成的必要步骤，因此在这种条件下，这些化合物对 PI 3- 激酶的抑制可抑制或防止血栓形成。这些化合物可用于治疗 PI 3- 激酶依赖性疾病，包括心血管疾病，如冠状动脉闭塞、中风、急性冠状动脉综合征、急性心肌梗塞、血管再狭窄、动脉粥样硬化和不稳定型心绞痛；呼吸系统疾病，如哮喘、慢性阻塞性肺病（COPD）和支气管炎；炎症性疾病；肿瘤，包括胶质瘤、前列腺癌、小细胞肺癌和乳腺癌等癌症；以及与白细胞功能紊乱有关的疾病，如自身免疫性疾病和炎症性疾病。
• AROMATIC POLYESTER
  申请人：Muroran Institute of Technology

  公开号：EP2479203A1

  公开（公告）日：2012-07-25

  The present invention provides an aromatic polyester which is substantially free from the occurrence of coloration and retains significantly high transparency even after being thermally processed at high temperature and which has high flowability. The aromatic polyester contains a polyhydric phenol residue and a residue of any one of aromatic polycarboxylic acid, halide thereof, and anhydride thereof, and terminals of the aromatic polyester have a structure represented by the formula -C(O)-R. The aromatic polyester has an end-capping rate of 90% or higher and a weight average molecular weight (Mw) ranging from 3,000 to 1,000,000.

  本发明提供了一种芳香族聚酯，该聚酯基本上不会发生着色，即使在高温热加工后仍能保持明显的高透明度，并且具有高流动性。芳香族聚酯含有多羟基苯酚残留物和芳香族多羧酸、其卤化物和其酸酐中任意一种的残留物，芳香族聚酯的端基具有式 -C(O)-R 所代表的结构。芳香族聚酯的端盖率为 90% 或更高，重量平均分子量（Mw）为 3,000 至 1,000,000 之间。
• PHOTONIC CRYSTAL STRUCTURE AND ANTI-FORGERY COLOR CONVERSION FILM COMPRISING SAME
  申请人：Korea Research Institute of Chemical Technology

  公开号：EP3566863A1

  公开（公告）日：2019-11-13

  The present invention provides an anti-forgery color conversion film including a photonic crystal structure whose color is converted by an external stimulus such as a breath, whereby a consumer who purchases an article including the color conversion film may easily distinguish the authenticity of the article.

  本发明提供了一种防伪色彩转换膜，包括光子晶体结构，其色彩可在呼吸等外部刺激下进行转换，从而使购买了包含该色彩转换膜的物品的消费者可以轻松辨别物品的真伪。
• Vinyl-containing compounds with high heat distortion
  申请人：REICHHOLD LLC 2

  公开号：US10544299B2

  公开（公告）日：2020-01-28

  A process for forming a thermosetting resin in a nitrogen atmosphere is provided. The process includes the steps of a) reacting a polycarboxylic acid and/or anhydride and a polyhydric alcohol to provide a hydroxyl-containing intermediate; b) reacting the hydroxyl-containing intermediate with a vinyl-containing organic acid or vinyl containing alkyl ester in the presence of an esterification catalyst, a polymerization inhibitor and an azeotropic agent; and c) reacting any residual vinyl-containing organic acid and residual esterification catalyst with an epoxide.

  本发明提供了一种在氮气环境中形成热固性树脂的工艺。该工艺包括以下步骤：a) 使聚羧酸和/或酸酐与多元醇反应，生成含羟基的中间体；b) 在酯化催化剂、聚合抑制剂和共沸剂存在下，使含羟基的中间体与含乙烯基的有机酸或含乙烯基的烷基酯反应；以及 c) 使任何残留的含乙烯基的有机酸和残留的酯化催化剂与环氧化物反应。