5,6-bis(2,3-dichlorophenoxy)-1H-benzimidazole-2-(3H)-thione | 145770-93-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5,6-bis(2,3-dichlorophenoxy)-1H-benzimidazole-2-(3H)-thione
• 英文别名: 5,6-Bis(2,3-dichlorophenoxy)-1,3-dihydrobenzimidazole-2-thione
• CAS: 145770-93-0
• 化学式: C₁₉H₁₀Cl₄N₂O₂S
• 分子量: 472.179
• InChiKey: AYAVMEWEYPDNDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5,6-bis(2,3-dichlorophenoxy)-1H-benzimidazole-2-(3H)-thione 、 碘甲烷 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 2.5h， 以88%的产率得到5,6-bis(2,3-dichlorophenoxy)-2-methylthio-1H-benzimidazole
  参考文献：
  名称：

  2H-benzimidazoles (isobenzimidazoles). Part 7. A new route to triclabendazole [5-chloro-6-(2,3-dichlorophenoxy)-2-methylthio-1H-benzimidazole] and congeneric benzimidazoles

  摘要：

  A new synthesis of the selective anthelmintic agent triclabendazole 7 from the readily available 5,6-dichloro-2H-benzimidazole-2-spirocyclohexane 2 by simple steps is described. Analogous benzimidazoles difficult to prepare by conventional methods are similarly obtained. Triclabendazole can exist as a low-melting metastable solid (m.p. 85-90-degrees-C) convertible by heating or recrystallisation from ethanol into its stable form (m.p. 1 76-1 78-degrees-C).

  DOI：

  10.1039/p19920003129
• 作为产物：
  描述：

  5,6-dichloro-2H-benzimidazole-2-spirocyclohexane 在 sodium dithionite 、 sodium methylate 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 11.0h， 生成 5,6-bis(2,3-dichlorophenoxy)-1H-benzimidazole-2-(3H)-thione
  参考文献：
  名称：

  2H-benzimidazoles (isobenzimidazoles). Part 7. A new route to triclabendazole [5-chloro-6-(2,3-dichlorophenoxy)-2-methylthio-1H-benzimidazole] and congeneric benzimidazoles

  摘要：

  A new synthesis of the selective anthelmintic agent triclabendazole 7 from the readily available 5,6-dichloro-2H-benzimidazole-2-spirocyclohexane 2 by simple steps is described. Analogous benzimidazoles difficult to prepare by conventional methods are similarly obtained. Triclabendazole can exist as a low-melting metastable solid (m.p. 85-90-degrees-C) convertible by heating or recrystallisation from ethanol into its stable form (m.p. 1 76-1 78-degrees-C).

  DOI：

  10.1039/p19920003129

文献信息

• 2H-benzimidazoles (isobenzimidazoles). Part 7. A new route to triclabendazole [5-chloro-6-(2,3-dichlorophenoxy)-2-methylthio-1H-benzimidazole] and congeneric benzimidazoles
  作者：Brian Iddon、Peter Kutschy、Andrew G. Robinson、Hans Suschitzky、Walter Kramer、Franz A. Neugebauer

  DOI：10.1039/p19920003129

  日期：——

  A new synthesis of the selective anthelmintic agent triclabendazole 7 from the readily available 5,6-dichloro-2H-benzimidazole-2-spirocyclohexane 2 by simple steps is described. Analogous benzimidazoles difficult to prepare by conventional methods are similarly obtained. Triclabendazole can exist as a low-melting metastable solid (m.p. 85-90-degrees-C) convertible by heating or recrystallisation from ethanol into its stable form (m.p. 1 76-1 78-degrees-C).