(E)-4-(2-(pyridin-4-yl)vinyl)quinoline | 23096-60-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (E)-4-(2-(pyridin-4-yl)vinyl)quinoline
• 英文别名: 4-(2-pyridin-4-yl-vinyl)-quinoline；4-<β-(4'-Pyridyl)vinyl>chinolin；4-[(E)-2-pyridin-4-ylethenyl]quinoline
• CAS: 23096-60-8
• 化学式: C₁₆H₁₂N₂
• 分子量: 232.285
• InChiKey: UIJUAERZNNACII-AATRIKPKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(3-bromopropyl)-1H-pyrrole-2,5-dione 、 (E)-4-(2-(pyridin-4-yl)vinyl)quinoline 以 二氯甲烷 为溶剂， 以51%的产率得到(E)-1-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propyl]-4-[2-(quinolin-4-yl)vinyl]pyridin-1-ium bromide
  参考文献：
  名称：

  Maleimide-Functionalized Photochromic Spirodihydroindolizines

  摘要：

  Two photochromic spirodihydroindolizine/betaMe systems for tethering to peptides and proteins via a maleimide function have been prepared. The absorption spectra of the betaines are in the red region of the visible spectrum and in the near-IR spectral domain, which are suitable energies of light for future in vivo applications. The half-times of cyclization have been determined for both DHI/betaine systems. The findings are consistent with a thermal barrier of varying size between the transoid and cisoid conformers of the betaines.

  DOI：

  10.1021/jo301894s
• 作为产物：
  描述：

  4-吡啶甲醛 、 4-甲基喹啉 在 乙酸酐 作用下， 反应 48.0h， 以53%的产率得到(E)-4-(2-(pyridin-4-yl)vinyl)quinoline
  参考文献：
  名称：

  Maleimide-Functionalized Photochromic Spirodihydroindolizines

  摘要：

  Two photochromic spirodihydroindolizine/betaMe systems for tethering to peptides and proteins via a maleimide function have been prepared. The absorption spectra of the betaines are in the red region of the visible spectrum and in the near-IR spectral domain, which are suitable energies of light for future in vivo applications. The half-times of cyclization have been determined for both DHI/betaine systems. The findings are consistent with a thermal barrier of varying size between the transoid and cisoid conformers of the betaines.

  DOI：

  10.1021/jo301894s

文献信息

• Maleimide-Functionalized Photochromic Spirodihydroindolizines
  作者：Tej B. Shrestha、Mausam Kalita、Megh Raj Pokhrel、Yao Liu、Deryl L. Troyer、Claudia Turro、Stefan H. Bossmann、Heinz Dürr

  DOI：10.1021/jo301894s

  日期：2013.3.1

  Two photochromic spirodihydroindolizine/betaMe systems for tethering to peptides and proteins via a maleimide function have been prepared. The absorption spectra of the betaines are in the red region of the visible spectrum and in the near-IR spectral domain, which are suitable energies of light for future in vivo applications. The half-times of cyclization have been determined for both DHI/betaine systems. The findings are consistent with a thermal barrier of varying size between the transoid and cisoid conformers of the betaines.