7-hydrazinyl-6-fluoro-1-cyclopropyl-1,4-dihydro-4-oxo-quinoline-3-carbohydrazide | 1375100-68-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-hydrazinyl-6-fluoro-1-cyclopropyl-1,4-dihydro-4-oxo-quinoline-3-carbohydrazide
• 英文别名: 1-Cyclopropyl-6-fluoro-7-hydrazinyl-4-oxoquinoline-3-carbohydrazide
• CAS: 1375100-68-7
• 化学式: C₁₃H₁₄FN₅O₂
• 分子量: 291.285
• InChiKey: IDYAHVRSCBFFMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  114
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  7-hydrazinyl-6-fluoro-1-cyclopropyl-1,4-dihydro-4-oxo-quinoline-3-carbohydrazide 、 苯甲醛 以 乙醇 为溶剂， 以91%的产率得到3-(benzylidenehydrazinocarbonyl)-7-(N'-benzylidenehydrazino)-1-cycloproyl-6-fluoroquinolin-4(1H)-one
  参考文献：
  名称：

  Synthesis and antitumor and antibacterial evaluation of fluoro-quinolone derivatives (III): Mono- and bis-Schiff-bases

  摘要：

  To further explore an efficient modified route for the shift from an antibacterial fluoroquinolone to an antitumor one, mono-Schiff bases 6a-6h related to ciprofloxacin C3 carbonylhydrazone and bis-Schiff bases 4a-4h corresponding to C3/C7 carbonylhydrazone/hydrazone attached on a skeleton of ciprofloquinolone were designed and synthesized, and their in vitro antitumor activity against CHO, HL60, L1210 cells and antibacterial activity against Staphylococcus aureus and Escherichia coli were also reported. (C) 2012 Guo Qiang Hu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2012.01.029
• 作为产物：
  描述：

  7-氯-1-环丙基-6-氟-4-氧代-1,4-二氢-喹啉-3-羧酸乙基酯 在 一水合肼 作用下， 生成 7-hydrazinyl-6-fluoro-1-cyclopropyl-1,4-dihydro-4-oxo-quinoline-3-carbohydrazide
  参考文献：
  名称：

  Synthesis and antitumor and antibacterial evaluation of fluoro-quinolone derivatives (III): Mono- and bis-Schiff-bases

  摘要：

  To further explore an efficient modified route for the shift from an antibacterial fluoroquinolone to an antitumor one, mono-Schiff bases 6a-6h related to ciprofloxacin C3 carbonylhydrazone and bis-Schiff bases 4a-4h corresponding to C3/C7 carbonylhydrazone/hydrazone attached on a skeleton of ciprofloquinolone were designed and synthesized, and their in vitro antitumor activity against CHO, HL60, L1210 cells and antibacterial activity against Staphylococcus aureus and Escherichia coli were also reported. (C) 2012 Guo Qiang Hu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2012.01.029