3-<3-(3-phenyl-2-propyn-1-yloxy)-1,2,5-thiadiazol-4-yl>pyridine | 1018845-36-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-<3-(3-phenyl-2-propyn-1-yloxy)-1,2,5-thiadiazol-4-yl>pyridine
• 英文别名: 3-(3-((3-phenyl-2-propynyl)oxy)-1,2,5-thiadiazol-4-yl)pyridine；3-(3-Phenylprop-2-ynoxy)-4-pyridin-3-yl-1,2,5-thiadiazole
• CAS: 1018845-36-7
• 化学式: C₁₆H₁₁N₃OS
• 分子量: 293.349
• InChiKey: QGACNMYQEVQCRV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  76.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-<3-(3-phenyl-2-propyn-1-yloxy)-1,2,5-thiadiazol-4-yl>pyridine 在 sodium tetrahydroborate 作用下， 以 甲醇 、 丙酮 为溶剂， 反应 18.25h， 生成 1-Methyl-5-[4-(3-phenyl-prop-2-ynyloxy)-[1,2,5]thiadiazol-3-yl]-1,2,3,6-tetrahydro-pyridine
  参考文献：
  名称：

  1-(1,2,5-Thiadiazol-4-yl)-4-azatricyclo[2.2.1.0^2,6]heptanes as New Potent Muscarinic M₁ Agonists:  Structure−Activity Relationship for 3-Aryl-2-propyn-1-yloxy and 3-Aryl-2-propyn-1-ylthio Derivatives

  摘要：

  Two new series of 1-(1,2,5-thiadiazol-4-yl)-4-azatricyclo[2.2.1.0(2,6)]heptanes were synthesized and evaluated for their in vitro activity in cell lines transfected with either the human M-1 or M-2 receptor. 3-Phenyl-2-propyn-1-yloxy and -1-ylthio analogues substituted with halogen in the meta position showed high functional potency, efficacy, and selectivity toward the M-1 receptor subtype. A quite unique functional M-1 receptor selectivity was observed for compounds 8b, 8d, 8f, 9b, 9d, and 9f. Bioavailability studies in rats indicated an oral bioavailability of about 20-30%, with the N-oxide as the only detected metabolite.

  DOI：

  10.1021/jm9910019
• 作为产物：
  描述：

  3-苯基-2-丙炔-1-醇 、 3-氯-4-(吡啶-3-基)-1,2,5-噻二唑 在 sodium hydride 作用下， 生成 3-<3-(3-phenyl-2-propyn-1-yloxy)-1,2,5-thiadiazol-4-yl>pyridine
  参考文献：
  名称：

  1-(1,2,5-Thiadiazol-4-yl)-4-azatricyclo[2.2.1.0^2,6]heptanes as New Potent Muscarinic M₁ Agonists:  Structure−Activity Relationship for 3-Aryl-2-propyn-1-yloxy and 3-Aryl-2-propyn-1-ylthio Derivatives

  摘要：

  Two new series of 1-(1,2,5-thiadiazol-4-yl)-4-azatricyclo[2.2.1.0(2,6)]heptanes were synthesized and evaluated for their in vitro activity in cell lines transfected with either the human M-1 or M-2 receptor. 3-Phenyl-2-propyn-1-yloxy and -1-ylthio analogues substituted with halogen in the meta position showed high functional potency, efficacy, and selectivity toward the M-1 receptor subtype. A quite unique functional M-1 receptor selectivity was observed for compounds 8b, 8d, 8f, 9b, 9d, and 9f. Bioavailability studies in rats indicated an oral bioavailability of about 20-30%, with the N-oxide as the only detected metabolite.

  DOI：

  10.1021/jm9910019

文献信息

• Identification of side chains on 1,2,5-thiadiazole-azacycles optimal for muscarinic M1 receptor activation
  作者：Per Sauerberg、Lone Jeppesen、Preben H Olesen、Malcolm J Sheardown、Anders Fink-Jensen、Thøger Rasmussen、Karin Rimvall、Harlan E Shannon、Frank P Bymaster、Neil W DeLapp、Dave O Calligaro、John S Ward、Celia A Whitesitt、Christian Thomsen

  DOI：10.1016/s0960-894x(98)00509-5

  日期：1998.10

  Series of analogs to the functional mi selective agonist, xanomeline (hexyloxy-TZTP), were evaluated for their in vitro ml efficacy in cell lines transfected with the human ml receptor. Systematic variation of the side chain and the azacyclic ring led to the discovery of potent muscarinic agonists with robust ml efficacy, ail having the phenylpropargyloxy/thio as the side chain. The most selective compound was the phenylpropargylthio-[3.2.1] endo analog 28, which is a potent and efficacious mi agonist with no m2 activity. (C) 1998 Elsevier Science Ltd. All rights reserved.
• Synthesis and evaluation of xanomeline analogs—Probing the wash-resistant phenomenon at the M1 muscarinic acetylcholine receptor
  作者：Brian E. Kane、Marianne K.O. Grant、Esam E. El-Fakahany、David M. Ferguson

  DOI：10.1016/j.bmc.2007.10.058

  日期：2008.2.1

  A series of xanomeline analogs were synthesized and evaluated for binding at the M, muscarinic acetylcholine receptor (M-1 receptor). Specifically, compounds that substitute the O-hexyl chain of xanomeline with polar, ionizable, or conformationally restricted moieties were assessed for their ability to bind to the M, receptor in a wash-resistant manner (persistent binding). From our screen, several novel ligands that persistently bind to the M, receptor with greater affinity than xanomeline were discovered. Results indicate that persistent binding may arise not only from hydrophobic interactions but also from ionic interactions with a secondary M, receptor binding site. Herein, a qualitative model that accounts for both binding scenarios is proposed and applied to understand the structural basis to wash-resistant binding and long-acting effects of xanomeline-based compounds. (C) 2007 Elsevier Ltd. All rights reserved.
• 1-(1,2,5-Thiadiazol-4-yl)-4-azatricyclo[2.2.1.0^2,6]heptanes as New Potent Muscarinic M₁ Agonists:  Structure−Activity Relationship for 3-Aryl-2-propyn-1-yloxy and 3-Aryl-2-propyn-1-ylthio Derivatives
  作者：Lone Jeppesen、Preben H. Olesen、Lena Hansen、Malcolm J. Sheardown、Christian Thomsen、Thøger Rasmussen、Anders Fink Jensen、Michael S. Christensen、Karin Rimvall、John S. Ward、Celia Whitesitt、David O. Calligaro、Frank P. Bymaster、Neil W. Delapp、Christian C. Felder、Harlan E. Shannon、Per Sauerberg

  DOI：10.1021/jm9910019

  日期：1999.6.1

  Two new series of 1-(1,2,5-thiadiazol-4-yl)-4-azatricyclo[2.2.1.0(2,6)]heptanes were synthesized and evaluated for their in vitro activity in cell lines transfected with either the human M-1 or M-2 receptor. 3-Phenyl-2-propyn-1-yloxy and -1-ylthio analogues substituted with halogen in the meta position showed high functional potency, efficacy, and selectivity toward the M-1 receptor subtype. A quite unique functional M-1 receptor selectivity was observed for compounds 8b, 8d, 8f, 9b, 9d, and 9f. Bioavailability studies in rats indicated an oral bioavailability of about 20-30%, with the N-oxide as the only detected metabolite.