11H-Indolo[3,2-c]quinolin-8-ol | 766505-43-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 11H-Indolo[3,2-c]quinolin-8-ol
• CAS: 766505-43-5
• 化学式: C₁₅H₁₀N₂O
• 分子量: 234.257
• InChiKey: SZRYJIWTHHWMJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  48.9
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  二甲氨基氯乙烷盐酸 、 11H-Indolo[3,2-c]quinolin-8-ol 在 potassium carbonate 、 水 作用下， 以 氯仿 为溶剂， 反应 28.0h， 以75%的产率得到[2-(11H-Indolo[3,2-c]quinolin-8-yloxy)-ethyl]-dimethyl-amine
  参考文献：
  名称：

  Design of antineoplastic agents based on the '2-phenylnaphthalene-type' structural pattern—synthesis and biological activity studies of 11H-indolo[3.2-c]quinoline derivatives

  摘要：

  Designed as a new group of planar molecule containing the proposed 2-phenylnaphthalene-type structure, a number of 11H-indolo[3.2-c]quinoline derivatives were synthesized and evaluated biologically. Several compounds were found to possess cytotoxic activity against the growth of human promyclocytic leukemia cells (HL-60), against the small cell lung cancer (SCLC), and showed good response in the National Cancer Institute preclinical antitumor drug discovery 60-cell line panel. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

  DOI：

  10.1016/s0223-5234(02)01420-4
• 作为产物：
  描述：

  2,3-二氢-1H-喹啉-4-酮 在 盐酸 、 氢溴酸 作用下， 以 溶剂黄146 、 正丁醇 为溶剂， 反应 30.0h， 生成 11H-Indolo[3,2-c]quinolin-8-ol
  参考文献：
  名称：

  Design of antineoplastic agents based on the '2-phenylnaphthalene-type' structural pattern—synthesis and biological activity studies of 11H-indolo[3.2-c]quinoline derivatives

  摘要：

  Designed as a new group of planar molecule containing the proposed 2-phenylnaphthalene-type structure, a number of 11H-indolo[3.2-c]quinoline derivatives were synthesized and evaluated biologically. Several compounds were found to possess cytotoxic activity against the growth of human promyclocytic leukemia cells (HL-60), against the small cell lung cancer (SCLC), and showed good response in the National Cancer Institute preclinical antitumor drug discovery 60-cell line panel. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

  DOI：

  10.1016/s0223-5234(02)01420-4

文献信息

• Design of antineoplastic agents based on the '2-phenylnaphthalene-type' structural pattern—synthesis and biological activity studies of 11H-indolo[3.2-c]quinoline derivatives
  作者：L He

  DOI：10.1016/s0223-5234(02)01420-4

  日期：2003.1

  Designed as a new group of planar molecule containing the proposed 2-phenylnaphthalene-type structure, a number of 11H-indolo[3.2-c]quinoline derivatives were synthesized and evaluated biologically. Several compounds were found to possess cytotoxic activity against the growth of human promyclocytic leukemia cells (HL-60), against the small cell lung cancer (SCLC), and showed good response in the National Cancer Institute preclinical antitumor drug discovery 60-cell line panel. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.