4-amino-5-cyano-7-(5-deoxy-5-N-trifluoromethanesulfonylamino-β-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-amino-5-cyano-7-(5-deoxy-5-N-trifluoromethanesulfonylamino-β-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidine
• 英文别名: N-[[(2R,3S,4R,5R)-5-(4-amino-5-cyanopyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-1,1,1-trifluoromethanesulfonamide
• 化学式: C₁₃H₁₃F₃N₆O₅S
• 分子量: 422.345
• InChiKey: ANQKKCUQZKZENP-WOUKDFQISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  185
• 氢给体数：
  4
• 氢受体数：
  13

反应信息

• 作为产物：
  描述：

  methyl 5-azido-5-deoxy-2,3-O-isopropylidene-b-ribofuranoside 在 palladium on activated charcoal 吡啶 、 盐酸 、 甲醇 、 三甲基氯硅烷 、 TMSTf 、 硫酸 、 氨 、 氢气 、 三乙胺 、 六甲基二硅氮烷 作用下， 以 1,4-二氧六环 、 溶剂黄146 、 N,N-二甲基甲酰胺 为溶剂， 反应 129.67h， 生成 4-amino-5-cyano-7-(5-deoxy-5-N-trifluoromethanesulfonylamino-β-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidine
  参考文献：
  名称：

  Synthesis of 5′-Fluoro-5′-deoxy-and 5′-Amino-5′-Deoxytoyocamycin and Sangivamycin and Some Related Derivatives

  摘要：

  A series of 5'-substituted analogs of toyocamycin were prepared by condensation of silylated 4-amino-6-bromo-5-cyanopyrrolo[2,3-d]pyrimidine with protected 5-azidod-deoxy- or 5-fluoro-5-deoxyribofuranose followed by debromination and deblocking. Alternatively, 5'-azido-5'-deoxytoyocamycin was prepared by azidation of toyocamycin. Conversion of the 5-nitrile function of the toyocamycin derivatives into a carboxamide or a thiocarboxamide gave the corresponding analogs of sangivamycin or thiosangivamycin while reduction of the 5'-azido-5'-deoxy nucleosides provided 5'-amino-5'-deoxy derivatives.

  DOI：

  10.1080/15257779508010707

文献信息

• Synthesis of 5′-Fluoro-5′-deoxy-and 5′-Amino-5′-Deoxytoyocamycin and Sangivamycin and Some Related Derivatives
  作者：Moheshwar Sharma、Yi X. Li、Miroslav Ledvina、Miroslav Bobek

  DOI：10.1080/15257779508010707

  日期：1995.11

  A series of 5'-substituted analogs of toyocamycin were prepared by condensation of silylated 4-amino-6-bromo-5-cyanopyrrolo[2,3-d]pyrimidine with protected 5-azidod-deoxy- or 5-fluoro-5-deoxyribofuranose followed by debromination and deblocking. Alternatively, 5'-azido-5'-deoxytoyocamycin was prepared by azidation of toyocamycin. Conversion of the 5-nitrile function of the toyocamycin derivatives into a carboxamide or a thiocarboxamide gave the corresponding analogs of sangivamycin or thiosangivamycin while reduction of the 5'-azido-5'-deoxy nucleosides provided 5'-amino-5'-deoxy derivatives.