摩熵化学
数据库官网
小程序
打开微信扫一扫
首页 分子通 化学资讯 化学百科 反应查询 关于我们
请输入关键词

6-cyanomethyl-2-(α-bromoacetyl)pyridine | 1026809-13-1

中文名称
——
中文别名
——
英文名称
6-cyanomethyl-2-(α-bromoacetyl)pyridine
英文别名
2-[6-(2-Bromoacetyl)pyridin-2-yl]acetonitrile
6-cyanomethyl-2-(α-bromoacetyl)pyridine化学式
CAS
1026809-13-1
化学式
C9H7BrN2O
mdl
——
分子量
239.071
InChiKey
ZYULYPCIAAQJIC-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    1.4
  • 重原子数:
    13
  • 可旋转键数:
    3
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.22
  • 拓扑面积:
    53.8
  • 氢给体数:
    0
  • 氢受体数:
    3

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    参考文献:
    名称:
    Studies on antiulcer drugs. 7. 2-Guanidino-4-pyridylthiazoles as histamine H2-receptor antagonists with potent gastroprotective effects against nonsteroidal antiinflammatory drug-induced injury
    摘要:
    A series of 2-guanidino-4-pyridylthiazole derivatives were synthesized and evaluated for anti-aspirin-ulcer, gastric antisecretory, and histamine-H-2-receptor-antagonist activities. Several compounds showed superior anti-aspirin-ulcer activity to that of clinically used H-2-antagonists in the rat. Among them, 4-[6-(acetamidomethyl)pyridin-2-yl]-2-guanidinothiazole (8) demonstrated potent inhibitory activities against gastric lesions caused by two kinds of nonsteroidal antiinflammatory drugs, aspirin and indomethacin, respectively, in addition to strong antisecretory activity. Compound 8 possessed a preventable ability for the aspirin-induced reduction of the gastric mucosal blood flow at an intragastric administration of 32 mg/kg in the rat. On the other hand, famotidine (32 mg/kg) exhibited no significant effect and ranitidine (100 mg/kg) aggravated the blood flow in this system.
    DOI:
    10.1021/jm00027a007
  • 作为产物:
    描述:
    1-[6-(氯甲基)吡啶-2-基]乙酮氢溴酸溶剂黄146 作用下, 以 甲醇 为溶剂, 反应 2.0h, 生成 6-cyanomethyl-2-(α-bromoacetyl)pyridine
    参考文献:
    名称:
    Studies on antiulcer drugs. 7. 2-Guanidino-4-pyridylthiazoles as histamine H2-receptor antagonists with potent gastroprotective effects against nonsteroidal antiinflammatory drug-induced injury
    摘要:
    A series of 2-guanidino-4-pyridylthiazole derivatives were synthesized and evaluated for anti-aspirin-ulcer, gastric antisecretory, and histamine-H-2-receptor-antagonist activities. Several compounds showed superior anti-aspirin-ulcer activity to that of clinically used H-2-antagonists in the rat. Among them, 4-[6-(acetamidomethyl)pyridin-2-yl]-2-guanidinothiazole (8) demonstrated potent inhibitory activities against gastric lesions caused by two kinds of nonsteroidal antiinflammatory drugs, aspirin and indomethacin, respectively, in addition to strong antisecretory activity. Compound 8 possessed a preventable ability for the aspirin-induced reduction of the gastric mucosal blood flow at an intragastric administration of 32 mg/kg in the rat. On the other hand, famotidine (32 mg/kg) exhibited no significant effect and ranitidine (100 mg/kg) aggravated the blood flow in this system.
    DOI:
    10.1021/jm00027a007
点击查看最新优质反应信息

文献信息

  • Thiazole derivatives
    申请人:Otsuka Pharmaceutical Co., Ltd.
    公开号:US05639770A1
    公开(公告)日:1997-06-17
    A thiazole derivative of the general formula: ##STR1## The thiazole derivatives have an excellent inhibitory activity for superoxide radical.
    一种通式为##STR1##的噻唑衍生物。这些噻唑衍生物对超氧自由基具有出色的抑制活性。
  • THIAZOLE DERIVATIVE
    申请人:OTSUKA PHARMACEUTICAL CO., LTD.
    公开号:EP0600092A1
    公开(公告)日:1994-06-08
    A thiazole derivative which is excellent in an active oxygen inhibitory effect, represented by general formula (I), wherein R¹ represents phenyl which may be substituted by 1 to 3 lower alkoxy groups, and R² represents an optionally substituted pyridylcarbonyl group, a 5- to 15-membered mono-, di- or tricyclic heterocyclic group bearing 1 to 3 nitrogen, oxygen or sulfur atoms, or a substituted phenyl group.
    一种活性氧抑制效果极佳的噻唑衍生物,由通式(I)表示,其中 R¹ 代表可被 1 至 3 个低级烷氧基取代的苯基,R² 代表任选取代的吡啶羰基、含有 1 至 3 个氮、氧或硫原子的 5 至 15 元单环、二环或三环杂环基团或取代的苯基。
  • US5639770A
    申请人:——
    公开号:US5639770A
    公开(公告)日:1997-06-17
  • Studies on antiulcer drugs. 7. 2-Guanidino-4-pyridylthiazoles as histamine H2-receptor antagonists with potent gastroprotective effects against nonsteroidal antiinflammatory drug-induced injury
    作者:Yousuke Katsura、Yoshikazu Inoue、Tetsuo Tomishi、Hirohumi Ishikawa、Hisashi Takasugi
    DOI:10.1021/jm00027a007
    日期:1994.1
    A series of 2-guanidino-4-pyridylthiazole derivatives were synthesized and evaluated for anti-aspirin-ulcer, gastric antisecretory, and histamine-H-2-receptor-antagonist activities. Several compounds showed superior anti-aspirin-ulcer activity to that of clinically used H-2-antagonists in the rat. Among them, 4-[6-(acetamidomethyl)pyridin-2-yl]-2-guanidinothiazole (8) demonstrated potent inhibitory activities against gastric lesions caused by two kinds of nonsteroidal antiinflammatory drugs, aspirin and indomethacin, respectively, in addition to strong antisecretory activity. Compound 8 possessed a preventable ability for the aspirin-induced reduction of the gastric mucosal blood flow at an intragastric administration of 32 mg/kg in the rat. On the other hand, famotidine (32 mg/kg) exhibited no significant effect and ranitidine (100 mg/kg) aggravated the blood flow in this system.
查看更多