2-<(morpholino)thiocarbonyl>quinoline | 120095-85-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-<(morpholino)thiocarbonyl>quinoline
• 英文别名: 4-(quinoline-2-thiocarbonyl)-morpholine；4-(Chinolin-2-thiocarbonyl)-morpholin；Morpholin-4-yl(quinolin-2-yl)methanethione
• CAS: 120095-85-4
• 化学式: C₁₄H₁₄N₂OS
• 分子量: 258.344
• InChiKey: DBVLSCPZVVATMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  57.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-<(morpholino)thiocarbonyl>quinoline 在 三乙烯二胺 、 水 作用下， 生成 quinoline-2-carbothioic acid S-methyl ester
  参考文献：
  名称：

  Solvent-Free Conversion of Thioamides to Thioesters

  摘要：

  [image omitted] Diverse thioesters were efficiently prepared via the solvent-free reaction of thioamide derivatives with alkyl halides in the presence of catalytic amounts of 1,4-diazabicyclo[2.2.2]octane (DABCO) in small quantities of water and in good to excellent yields.

  DOI：

  10.1080/00397911.2010.503001
• 作为产物：
  描述：

  2-甲基喹啉 在 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 反应 25.0h， 生成 2-<(morpholino)thiocarbonyl>quinoline
  参考文献：
  名称：

  Al-Shaar, Adnan H.M.; Gilmour, David W.; Lythgoe, David J., Journal of the Chemical Society. Perkin transactions I, 1988, p. 3019 - 3024

  摘要：

  DOI：

文献信息

• Highly efficient synthesis of thioesters in water
  作者：Hassan Zali Boeini、Maryam Eshghi Kashan

  DOI：10.1039/b916852d

  日期：——

  Thioesters were efficiently prepared via the direct reaction of tertiary thioamides and alkyl halides in water, and in the presence of catalytic amounts of NaI, hexadecyltrimethylammonium bromide (HTAB), and 1,4-diazabicyclo[2.2.2]octane (DABCO). Hence, thioamides smoothly undergo an S-alkylation with alkyl halides in aqueous media following by hydrolysis to afford the corresponding thioesters in very good to excellent yields.

  在 NaI、十六烷基三甲基溴化铵（HTAB）和 1,4-二氮杂双环[2.2.2]辛烷（DABCO）的催化下，通过叔硫酰胺和烷基卤化物在水中的直接反应，可以高效地制备硫代酯。因此，硫代酰胺在水介质中可以顺利地与烷基卤化物发生 S-烷基化反应，然后通过水解得到相应的硫代酯，收率非常好甚至非常高。
• Zinc Chloride Catalyzed Ring Opening of N-Arylsulfonyl Aziridines by Thioamides: A New Approach to the Synthesis of Amidines
  作者：Hassan Zali-Boeini、Khadijeh Hajibabaei

  DOI：10.1055/s-0034-1378376

  日期：——

  The first zinc chloride catalyzed ring opening of N-arylsulfonyl aziridines by thioamides is described. Various thioamides were reacted with N-arylsulfonyl aziridines in the presence of a catalytic amount of dry zinc chloride to provide the corresponding N-arylsulfonyl amidine derivatives with good to excellent yields.
• Schmitt; Suquet, Bulletin de la Societe Chimique de France, 1956, p. 755,756
  作者：Schmitt、Suquet

  DOI：——

  日期：——
• AL-SHAAR, ADNAN H. M.;GILMOUR, DAVID W.;LYTHGOE, DAVID J.;MCCLENAGHAN, IA+, J. CHEM. SOC. PERKIN TRANS. PT 1,(1988) N1, C. 3019-3023
  作者：AL-SHAAR, ADNAN H. M.、GILMOUR, DAVID W.、LYTHGOE, DAVID J.、MCCLENAGHAN, IA+

  DOI：——

  日期：——
• Al-Shaar, Adnan H.M.; Gilmour, David W.; Lythgoe, David J., Journal of the Chemical Society. Perkin transactions I, 1988, p. 3019 - 3024
  作者：Al-Shaar, Adnan H.M.、Gilmour, David W.、Lythgoe, David J.、McClenaghan, Ian、Ramsden, Christopher A.

  DOI：——

  日期：——