1,3-bis(4-hydroxyphenyl)pent-4-en-1-one

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 英文名称: 1,3-bis(4-hydroxyphenyl)pent-4-en-1-one
• 英文别名: 1,3-di-p-hydroxyphenyl-4-penten-1-one
• 化学式: C₁₇H₁₆O₃
• 分子量: 268.312
• InChiKey: AVGYGUNTLQSTKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,3-bis(4-hydroxyphenyl)pent-4-en-1-one 在 盐酸 、 sodium tetrahydroborate 作用下， 以 甲醇 、 乙醇 、 水 为溶剂， 反应 24.0h， 生成 (E)-4,4'-(3-ethenyl-1-propene-1,3-diyl)bisphenol
  参考文献：
  名称：

  Synthesis of norlignans and in vitro inhibitory activity of antigen-induced degranulation

  摘要：

  The synthesis and biological evaluation of a series of novel norlignans are described. Norlignans were evaluated for their inhibitory activity on the release of beta-hexosaminidase, a marker of degranulation, from RBL-2H3 cells induced by the IgE-antigen complex. The results showed that norlignans 4c and 4e potently inhibited degranulation, with IC50 values of 18.3 and 17.9 mu M, respectively. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.04.033
• 作为产物：
  描述：

  对羟基苯甲醛 在 copper(l) iodide 作用下， 以 四氢呋喃 为溶剂， 反应 0.17h， 生成 1,3-bis(4-hydroxyphenyl)pent-4-en-1-one
  参考文献：
  名称：

  Synthesis of norlignans and in vitro inhibitory activity of antigen-induced degranulation

  摘要：

  The synthesis and biological evaluation of a series of novel norlignans are described. Norlignans were evaluated for their inhibitory activity on the release of beta-hexosaminidase, a marker of degranulation, from RBL-2H3 cells induced by the IgE-antigen complex. The results showed that norlignans 4c and 4e potently inhibited degranulation, with IC50 values of 18.3 and 17.9 mu M, respectively. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.04.033

文献信息

• Composition Comprising the Extract of Anemarrhena Asphodeloides Bunge or the Compounds Isolated from the Same for Preventing and Treating Lipid Metabolism Disorder
  申请人：Seo Eun Kyoung

  公开号：US20120070515A1

  公开（公告）日：2012-03-22

  The present invention relates to a composition comprising an extract of Anemarrhena asphodeloides Bunge or the compounds isolated from the same, as an active ingredient. In particular, the extract and compounds have the excellent inhibitory effects on adipocyte differentiation, and thus can be used in a pharmaceutical composition and functional food for the prevention and treatment of lipid metabolism disorders.

  本发明涉及一种包含知母提取物或从中分离出的化合物的组合物，作为活性成分。具体来说，该提取物和化合物具有出色的抑制脂肪细胞分化作用，因此可用于制备用于预防和治疗脂质代谢紊乱的药物组合物和功能性食品。
• STABLE FORMULATIONS OF A HYALURONAN-DEGRADING ENZYME
  申请人：Halozyme, Inc.

  公开号：EP2720712A2

  公开（公告）日：2014-04-23
• CONTINUOUS SUBCUTANEOUS INSULIN INFUSION METHODS WITH A HYALURONAN DEGRADING ENZYME
  申请人：Halozyme, Inc.

  公开号：EP2720713A2

  公开（公告）日：2014-04-23
• Stable formulations of a hyaluronan-degrading enzyme
  申请人：Yang Tzung-Horng

  公开号：US20130011378A1

  公开（公告）日：2013-01-10

  Provided are compositions that are stable formulations of a hyaluronan-degrading enzyme or are stable co-formulations of a fast-acting insulin and a hyaluronan degrading enzyme, including a recombinant human PH20 (rHuPH20).
• Stable formulations of a hyaluronan-degrading enzyme related applications
  申请人：Yang Tzung-Horng

  公开号：US20130022588A1

  公开（公告）日：2013-01-24

  Provided are compositions that are stable formulations of a hyaluronan-degrading enzyme or are stable co-formulations of a fast-acting insulin and a hyaluronan degrading enzyme, including a recombinant human PH20 (rHuPH20).