(5Z)-3-prop-2-enyl-5-(quinolin-2-ylmethylidene)-2-sulfanylideneimidazolidin-4-one | 1336986-89-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (5Z)-3-prop-2-enyl-5-(quinolin-2-ylmethylidene)-2-sulfanylideneimidazolidin-4-one
• CAS: 1336986-89-0
• 化学式: C₁₆H₁₃N₃OS
• 分子量: 295.365
• InChiKey: IYFZWQUNQNNUBI-UVTDQMKNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  77.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (5Z)-3-prop-2-enyl-5-(quinolin-2-ylmethylidene)-2-sulfanylideneimidazolidin-4-one 、 碘甲烷 在 potassium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 以72%的产率得到(5Z)-2-methylsulfanyl-3-prop-2-enyl-5-(quinolin-2-ylmethylidene)imidazol-4-one
  参考文献：
  名称：

  Novel DNA fluorescence probes based on 2-thioxo-tetrahydro-4H-imidazol-4-ones: synthetic and biological studies

  摘要：

  An efficient method for the liquid-phase synthesis of 3,5-disubstituted thiohydantoins has been developed. This new class of substituted thiohydantoins was tested as DNA fluorescence probes. Anthracene-substituted thiohydantoin undergoes a change in fluorescence in the presence of DNA. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.10.118
• 作为产物：
  描述：

  喹啉-2-甲醛 、 3-丙-2-烯基-2-巯基咪唑烷-4-酮 在 potassium hydroxide 、 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 12.0h， 以83%的产率得到(5Z)-3-prop-2-enyl-5-(quinolin-2-ylmethylidene)-2-sulfanylideneimidazolidin-4-one
  参考文献：
  名称：

  Novel DNA fluorescence probes based on 2-thioxo-tetrahydro-4H-imidazol-4-ones: synthetic and biological studies

  摘要：

  An efficient method for the liquid-phase synthesis of 3,5-disubstituted thiohydantoins has been developed. This new class of substituted thiohydantoins was tested as DNA fluorescence probes. Anthracene-substituted thiohydantoin undergoes a change in fluorescence in the presence of DNA. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.10.118

文献信息

• Novel DNA fluorescence probes based on 2-thioxo-tetrahydro-4H-imidazol-4-ones: synthetic and biological studies
  作者：Alexander G. Majouga、Anna V. Udina、Elena K. Beloglazkina、Dmitrii A. Skvortsov、Maria I. Zvereva、Olga A. Dontsova、Nikolay V. Zyk、Nikolay S. Zefirov

  DOI：10.1016/j.tetlet.2011.10.118

  日期：2012.1

  An efficient method for the liquid-phase synthesis of 3,5-disubstituted thiohydantoins has been developed. This new class of substituted thiohydantoins was tested as DNA fluorescence probes. Anthracene-substituted thiohydantoin undergoes a change in fluorescence in the presence of DNA. (C) 2011 Elsevier Ltd. All rights reserved.