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(E)-2-methyl-2-butene-1-ylmagnesium bromide | 129433-39-2

中文名称
——
中文别名
——
英文名称
(E)-2-methyl-2-butene-1-ylmagnesium bromide
英文别名
(E)-2-methyl-2-buten-1-ylmagnesium bromide;2-Methyl-2-butenylmagnesium bromide
(E)-2-methyl-2-butene-1-ylmagnesium bromide化学式
CAS
129433-39-2
化学式
C5H9BrMg
mdl
——
分子量
173.335
InChiKey
PDRRWJFZFIUXLR-WNCVTPEDSA-M
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    2.39
  • 重原子数:
    7.0
  • 可旋转键数:
    2.0
  • 环数:
    0.0
  • sp3杂化的碳原子比例:
    0.6
  • 拓扑面积:
    0.0
  • 氢给体数:
    0.0
  • 氢受体数:
    0.0

反应信息

  • 作为反应物:
    描述:
    (E)-2-methyl-2-butene-1-ylmagnesium bromide2,6-二甲基吡啶重铬酸吡啶 、 9-borabicyclo[3.3.1]nonane dimer 、 四丁基氟化铵叔丁基锂 作用下, 以 四氢呋喃二氯甲烷 为溶剂, 反应 19.33h, 生成
    参考文献:
    名称:
    Total Synthesis of Eupomatilones 4 and 6:  Structurally Rearranged and Atropisomerically Fluxional Lignan Natural Products
    摘要:
    A convergent and diastereocontrolled total synthesis of eupomatilones 4 and 6 is reported and was based on a diastereoselective hydroboration/oxidation sequence and a convergent Lipshutz biarylcuprate cross-coupling reaction. The structure of eupomatilone 6 is revised.
    DOI:
    10.1021/ol048333e
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文献信息

  • Asymmetric Total Synthesis of Dibenzocyclooctadiene Lignan Natural Products
    作者:Robert S. Coleman、Srinivas Reddy Gurrala、Soumya Mitra、Amresh Raao
    DOI:10.1021/jo051525i
    日期:2005.10.1
    Full details of the asymmetric total syntheses of the dibenzocyclooctadiene lignans interiotherin A, angeloylgomisin R, gomisin O, and gomisin E (epigomisin O) are presented. The syntheses were based on a unified synthetic strategy involving a novel crotylation using the Leighton auxiliary that occurred with excellent asymmetric induction (>98:2 enantiomeric ratio), a diastereoselective hydroboration/Suzuki−Miyaura
    介绍了二苯并环辛二烯木脂素interotherotherin A,当归基gomisin R,gomisin O和gomisin E(epigomisin O)的不对称总合成的全部细节。合成基于统一的合成策略,该策略涉及使用Leighton助剂进行新的丁酰化,并具有出色的不对称诱导(> 98:2对映体比率),非对映选择性氢化/ Suzuki-Miyaura偶联反应序列以及对映非对映选择性联芳基酸酯偶联,其中发生了全部(> 20:1)立体声控制。从简单的芳香族前体分六步到八步完成了合成。
  • ?-Complexes of transition metals in organic synthesis. 9. Reactions of allyl organomanganese compounds with ?-bromine derivatives of esters of ?, ?-unsaturated carboxylic acids
    作者:A. N. Kasatkin、O. Yu. Tsypyshev、T. Yu. Romanova、G. A. Tolstikov
    DOI:10.1007/bf00957998
    日期:1991.3
    The allyl Mn(II) organic compounds R1CH = C(R2)CH2MnCl (R1 = H, Me; R2 = H, Me, Bu), obtained in situ from Grignard reagents and Li2MnCl4, react with esters of 4-bromocrotonic, (2-bromobutylidene)-, (4-bromo-2-butenylidene)-, (2-bromoisobutylidene)malonic, and (2-bromoheptylidene)cyanoacetic acids in THF at -78 to +20-degrees-C to give derivatives of substituted cyclopropanecarboxylic or cyclopropane-1,1-dicarboxylic acids. These derivatives contain a fragment of the allyl type. When ethers of 2-(bromomethyl)acrylic, 4-bromo-2-methyl-, and 4-bromo-3-methyl-2-butenoic acids are used, cross-combination products result.
  • Total Synthesis of the Eupomatilones
    作者:Soumya Mitra、Srinivas Reddy Gurrala、Robert S. Coleman
    DOI:10.1021/jo701415m
    日期:2007.11.1
    Full details of the total syntheses of five members of the eupomatilone family of lignans are reported.
  • KASATKIN, A. N.;TSYPYSHEV, O. YU.;ROMANOVA, T. YU.;TOLSTIKOV, G. A., IZV. AN CCCP. CEP. XIM.,(1991) N, S. 656-663
    作者:KASATKIN, A. N.、TSYPYSHEV, O. YU.、ROMANOVA, T. YU.、TOLSTIKOV, G. A.
    DOI:——
    日期:——
  • EL, IDRISSI MOSTAFA;SANTELLI, MAURICE, J. ORG. CHEM., 53,(1988) N 5, 1010-1016
    作者:EL, IDRISSI MOSTAFA、SANTELLI, MAURICE
    DOI:——
    日期:——
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