4H-1-苯并吡喃-4-酮,2-(3,4-二甲氧苯基)-5-羟基-3,7,8-三甲氧基- | 14965-12-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 中文名称: 4H-1-苯并吡喃-4-酮,2-(3,4-二甲氧苯基)-5-羟基-3,7,8-三甲氧基-
• 英文名称: 2-(3,4-dimethoxy-phenyl)-5-hydroxy-3,7,8-trimethoxy-chromen-4-one
• 英文别名: 5-hydroxy-3,7,8-trimethoxy-2-(3,4-dimethoxyphenyl)-4-benzopyrone；5-hydroxy-3,7,8,3',4'-pentamethoxyflavone；limocitrin 3,7,4'-trimethyl ether；2-(3,4-Dimethoxy-phenyl)-5-hydroxy-3,7,8-trimethoxy-chromen-4-on；2-(3,4-dimethoxyphenyl)-5-hydroxy-3,7,8-trimethoxychromen-4-one
• CAS: 14965-12-9
• 化学式: C₂₀H₂₀O₈
• 分子量: 388.374
• InChiKey: NPMMYTVKEWLZKD-UHFFFAOYSA-N

物化性质

• 熔点：
  156-157 °C
• 沸点：
  609.6±55.0 °C(Predicted)
• 密度：
  1.37±0.1 g/cm3(Predicted)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  92.7
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  4H-1-苯并吡喃-4-酮,2-(3,4-二甲氧苯基)-5-羟基-3,7,8-三甲氧基- 在 硝酸 作用下， 生成 2-(3,4-dimethoxy-phenyl)-3,7-dimethoxy-chromene-4,5,8-trione
  参考文献：
  名称：

  Rao; Seshadri, Proceedings - Indian Academy of Sciences, Section A, 1947, # 25, p. 417,423

  摘要：

  DOI：
• 作为产物：
  描述：

  栎精-3,5,7,3,4-五甲醚 在 二甲基二环氧乙烷 、 三溴化硼 、 potassium carbonate 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 5.33h， 生成 4H-1-苯并吡喃-4-酮,2-(3,4-二甲氧苯基)-5-羟基-3,7,8-三甲氧基-
  参考文献：
  名称：

  Regioselective hydroxylation of 2-hydroxychalcones by dimethyldioxirane towards polymethoxylated flavonoids

  摘要：

  The flavone nucleus is part of a large number of natural products and medicinal compounds. In this presentation the novel regioselective hydroxylation of hydroxyarenes with DMD is described. The results showed further that flavonoids with 5-hydroxy group were selectively oxyfunctionalized at the para-position C8 carbon atom by DMD. Finally, according to this methodology, the naturally occurring isosinensetin, tangeretin, sinensetin, nobiletin, natsudaidain, gardenin B, 3,3',4',5,6,7,8-heptamethoxyflavone, quercetin and its derivatives were synthesized. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.01.023

文献信息

• USE OF FLAVONE AND FLAVANONE DERIVATIVES IN PREPARATION OF SEDATIVE AND HYPNOTIC DRUGS
  申请人：Jin Yongri

  公开号：US20150196529A1

  公开（公告）日：2015-07-16

  Disclosed is a use of flavones derivatives and flavanone derivatives in preparation of sedative and hypnotic drugs.

  本发明揭示了在制备镇静催眠药物中使用黄酮衍生物和黄酮酮衍生物的用途。
• Compositions and methods of treating, reducing and preventing cardiovascular diseases and disorders with polymethoxyflavones
  申请人：——

  公开号：US20040214882A1

  公开（公告）日：2004-10-28

  Compositions and methods for the treatment, reduction and/or prevention of cardiovascular diseases and disorders are described. Individuals at high risk for developing or having cardiovascular disease or disorder may be treated with an effective dose of a polymethoxyflavone including limocitrin derivatives, quercetin derivatives, naturally occurring polymethoxyflavones, tocotrienols, and mixtures of these compounds.

  本文描述了治疗、减少和/或预防心血管疾病和障碍的组合物和方法。高风险患有或可能发展心血管疾病或障碍的个体，可以接受有效剂量的多甲氧黄酮，包括柠檬黄素衍生物、槲皮素衍生物、天然多甲氧黄酮、生育三烯酚和这些化合物的混合物。
• Antioxidant compositions of vegetal origin and process for their preparation
  申请人：Edel Therapeutics S.A.

  公开号：EP1541159A1

  公开（公告）日：2005-06-15

  The antioxidant composition is of vegetal origin and is substantially free of mono-, di- or polysaccharides; it is more specifically an extract of pre-processed vegetal material like e.g. pressing residues of fruits or vegetables. The polysaccharides thus afforded can be further converted separately into an energetic substrate like alcohols or biogas. The process for the preparation of said antioxidant composition comprises as key reaction steps an extraction by means of a polar organic solvent as well an elution on polymer resin material suitable for fixing selectively polyphenols or the like while allowing the selective elution of mono-, di- or polysaccharides. Food or beverages, cosmetic or pharmaceutical compositions which contain the said antioxidant composition

  这种抗氧化剂组合物来源于植物，基本上不含单糖、双糖或多糖；更具体地说，它是一种经过预处理的植物材料的提取物，例如水果或蔬菜的压榨残渣。由此产生的多糖可以进一步单独转化为能量基质，如酒精或沼气。 制备上述抗氧化剂组合物的工艺包括以下关键反应步骤：用极性有机溶剂萃取，以及在适合选择性固定多酚或类似物质的聚合物树脂材料上洗脱，同时允许选择性洗脱单糖、二糖或多糖。 含有上述抗氧化剂成分的食品或饮料、化妆品或药物组合物
• METHODS OF TREATING LIVER DISEASE
  申请人：The J. David Gladstone Institutes

  公开号：EP3025727A1

  公开（公告）日：2016-06-01

  The present invention provides methods of treating liver steatosis, liver fibrosis and hepatitis C virus (HCV) infection; methods described include methods of reducing the incidence of complications associated with HCV and cirrhosis of the liver; and methods of reducing viral load, or reducing the time to viral clearance, or reducing morbidity or mortality in the clinical outcomes, in patients suffering from HCV infection.

  本发明提供了治疗肝脏脂肪变性、肝纤维化和丙型肝炎病毒（HCV）感染的方法；所述方法包括降低HCV和肝硬化相关并发症发病率的方法；以及降低HCV感染患者病毒载量、或缩短病毒清除时间、或降低临床结果中发病率或死亡率的方法。
• Soft gel capsules containing polymethoxylated flavones and palm oil tocotrienols
  申请人：Udell G. Ronald

  公开号：US20050249803A1

  公开（公告）日：2005-11-10

  The present invention is directed to soft gel compositions, methods of delivery and packaged nutraceuticals of the soft gel compositions that include at least one polymethoxylated flavone and, optionally, at least one tocotrienol.

  本发明涉及软凝胶组合物、给药方法和软凝胶组合物的包装营养保健品，这些软凝胶组合物包括至少一种聚甲氧基化黄酮和可选的至少一种生育三烯酚。