5-oxo-7,7-dimethyl-5,6,7,8-tetrahydrocarbostyril | 55119-00-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-oxo-7,7-dimethyl-5,6,7,8-tetrahydrocarbostyril
• 英文别名: 7,7-dimethyl-7,8-dihydroquinoline-2,5(1H,6H)-dione；7,7-dimethyl-6,8-dihydro-1H-quinoline-2,5-dione
• CAS: 55119-00-1
• 化学式: C₁₁H₁₃NO₂
• mdl: MFCD09837269
• 分子量: 191.23
• InChiKey: SSJBKGDLBXMVBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2933499090

反应信息

• 作为反应物：
  描述：

  5-oxo-7,7-dimethyl-5,6,7,8-tetrahydrocarbostyril 在 sodium methylate 作用下， 以 甲醇 为溶剂， 以100%的产率得到7,7-dimethyl-5-oxo-5,6,7,8-tetrahydrocarbostyril sodium salt
  参考文献：
  名称：

  Acetals of lactams and amides. 60. N- and O-alkylation of 5-oxo-5,6,7,8-tetrahydrocarbostyryils. Synthesis of isoxazolo[5,4-f]- and pyrazolo[3,4-f]quinolines

  摘要：

  DOI：

  10.1007/bf00633222
• 作为产物：
  描述：

  2-dimethylaminomethylene-5,5-dimethylcyclohexane-1,3-dione 在 盐酸 、 铜 作用下， 以 喹啉 、 乙醇 为溶剂， 反应 165.25h， 生成 5-oxo-7,7-dimethyl-5,6,7,8-tetrahydrocarbostyril
  参考文献：
  名称：

  Mosti, Luisa; Schenone, Pietro; Menozzi, Giulia, Journal of Heterocyclic Chemistry, 1985, vol. 22, p. 1503 - 1509

  摘要：

  DOI：

文献信息

• Synthesis and pharmacological activity of derivatives of pyrano- and pyrido-[3,2]carbazoles
  作者：A. K. Shanazarov、V. G. Granik、N. I. Andreeva、S. M. Golovina、M. D. Mashkovskii

  DOI：10.1007/bf00764806

  日期：1989.10

  of diaminodienyl diketones la, b has been previously used [i~ 2] to synthesize coumarin derivatives IIa, b, the reaction of which with ammonium acetate gave substituted carbostyrils IIIa, b. The alkylation of the Na salts of the latter with benzyl chloride and N,N-dimethylaminoethyl chloride proceeds at the ring nitrogen atom to give N-alkylcarbostyrils IIIc-e. The compounds that were synthesized by

  二氨基二烯基二酮la、b的分子内环化先前已用于[i～2]合成香豆素衍生物IIa、b，其与乙酸铵反应得到取代的喹诺酮IIIa、b。后者的Na盐与苄基氯和N，N-二甲基氨基乙基氯的烷基化在环氮原子处进行，得到N-烷基喹啉IIIc-e。通过该方法合成的化合物在其结构中含有羰基官能团；这确保了它们在 Fischer 反应中使用的可能性，以获得对研究其精神活性感兴趣的含四环吲哚的系统。
• Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors
  申请人：Jirgensons Aigars

  公开号：US20050197361A1

  公开（公告）日：2005-09-08

  The invention relates to tetrahydroquinolinone derivatives as well as their pharmaceutially acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are group I mGluR antagonists and are therefore useful for the control and prevention of acute and/or chronic neurological disorders.

  该发明涉及四氢喹诺酮衍生物及其药用可接受的盐。该发明还涉及一种制备这种化合物的方法。该发明的化合物是I组mGluR拮抗剂，因此对于控制和预防急性和/或慢性神经系统疾病非常有用。
• Dimeric compounds
  申请人：——

  公开号：US20020156096A1

  公开（公告）日：2002-10-24

  The invention relates to dimeric compounds comprising two 5-amino-5,6,7,8-tetrahydroquinoline fragments joined together by a divalent linking group, processes for their preparation, intermediates for their preparation, pharmaceutical compositions containing such dimeric compounds and the use of such compounds as cholinesterase inhibitors and in the treatment of neurodegenerative diseases, such as Alzheimer's Disease and myasthenia gravis.

  这项发明涉及由双价连接基团连接在一起的两个5-氨基-5,6,7,8-四氢喹啉片段构成的二聚化合物，以及其制备方法、制备中间体、含有这种二聚化合物的药物组合物，以及将这种化合物用作胆碱酯酶抑制剂和治疗神经退行性疾病，如阿尔茨海默病和重症肌无力的用途。
• 5-amino-5,6,7,8-tetrahydroquinolines and related compounds and
  申请人：Hoechst-Roussel Pharmaceuticals Inc.

  公开号：US05110815A1

  公开（公告）日：1992-05-05

  Novel 5-amino-5,6,7,8-tetrahydroquinolines and related compounds, intermediates and processes for the preparation thereof, and methods for relieving memory dysfunction utilizing compounds or compositions thereof are disclosed.

  揭示了新型5-氨基-5,6,7,8-四氢喹啉及其相关化合物、中间体和制备方法，以及利用这些化合物或组合物缓解记忆功能障碍的方法。
• Tetrahydroquinolones and their use as modulators of metabotropic glutamate receptors
  申请人：Jirgensons Aigars

  公开号：US20050288284A1

  公开（公告）日：2005-12-29

  The invention relates to ethynyl-substituted tetrahydroquinolinone derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are group I mGluR modulators and are therefore useful for the control and prevention of acute and/or chronic neurological disorders.

  该发明涉及乙炔基取代的四氢喹啉酮衍生物及其药学上可接受的盐。该发明进一步涉及一种制备这种化合物的方法。该发明的化合物是I组mGluR调节剂，因此对于控制和预防急性和/或慢性神经系统疾病有用。