4-(1-methyl-benzo[f]quinolin-3-yl)-aniline | 64953-49-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-(1-methyl-benzo[f]quinolin-3-yl)-aniline
• 英文别名: 4-(1-Methylbenzo[f]quinolin-3-yl)aniline
• CAS: 64953-49-7
• 化学式: C₂₀H₁₆N₂
• 分子量: 284.36
• InChiKey: VARUDEHSJDLCGK-UHFFFAOYSA-N

物化性质

• 沸点：
  503.0±40.0 °C(Predicted)
• 密度：
  1.211±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(1-methyl-benzo[f]quinolin-3-yl)-aniline 、 苯磺酰氯 在 吡啶 作用下， 反应 2.0h， 以47%的产率得到N-[4-(1-Methyl-benzo[f]quinolin-3-yl)-phenyl]-benzenesulfonamide
  参考文献：
  名称：

  摘要：

  Three-component condensation of 2-aminonaphthalene, acetone, and substituted benzaldehydes in alcoholic solution in the presence of concentrated hydrochloric acid gave 3-aryl-1-methylbenzo[f]quinolines. 1-Methyl-3-(nitrophenyl)benzo[f]quinolines were reduced to the corresponding amines which were converted into amides having a sulfonyl or chloroacetyl group in the aryl substituent.

  DOI：

  10.1023/a:1026077716902
• 作为产物：
  描述：

  1-methyl-3-(4-nitrophenyl)benzo[f]quinoline 在 盐酸 、 tin(ll) chloride 作用下， 以 异丙醇 为溶剂， 反应 1.0h， 以54%的产率得到4-(1-methyl-benzo[f]quinolin-3-yl)-aniline
  参考文献：
  名称：

  摘要：

  Three-component condensation of 2-aminonaphthalene, acetone, and substituted benzaldehydes in alcoholic solution in the presence of concentrated hydrochloric acid gave 3-aryl-1-methylbenzo[f]quinolines. 1-Methyl-3-(nitrophenyl)benzo[f]quinolines were reduced to the corresponding amines which were converted into amides having a sulfonyl or chloroacetyl group in the aryl substituent.

  DOI：

  10.1023/a:1026077716902

文献信息

• ANTIMICROBIAL COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Skaar Eric

  公开号：US20100004324A1

  公开（公告）日：2010-01-07

  In one aspect, the invention relates to compounds and methods useful for activating heme sensor systems; for decreasing virulence of bacteria, for example, Staphylococcus aureus; pharmaceutical compositions comprising the compounds; and methods of treating microbial-related disorders. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• US8263642B2
  申请人：——

  公开号：US8263642B2

  公开（公告）日：2012-09-11
• ——
  作者：N. G. Kozlov、L. I. Basalaeva

  DOI：10.1023/a:1026077716902

  日期：——

  Three-component condensation of 2-aminonaphthalene, acetone, and substituted benzaldehydes in alcoholic solution in the presence of concentrated hydrochloric acid gave 3-aryl-1-methylbenzo[f]quinolines. 1-Methyl-3-(nitrophenyl)benzo[f]quinolines were reduced to the corresponding amines which were converted into amides having a sulfonyl or chloroacetyl group in the aryl substituent.