2-Chloro-N-[4-(1-methyl-benzo[f]quinolin-3-yl)-phenyl]-acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-Chloro-N-[4-(1-methyl-benzo[f]quinolin-3-yl)-phenyl]-acetamide
• 英文别名: 2-chloro-N-[4-(1-methylbenzo[f]quinolin-3-yl)phenyl]acetamide
• 化学式: C₂₂H₁₇ClN₂O
• 分子量: 360.843
• InChiKey: USTYJTBWJVCAKG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-methyl-3-(4-nitrophenyl)benzo[f]quinoline 在 盐酸 、 三氟化硼乙醚 、 tin(ll) chloride 作用下， 以 1,4-二氧六环 、 异丙醇 为溶剂， 反应 1.67h， 生成 2-Chloro-N-[4-(1-methyl-benzo[f]quinolin-3-yl)-phenyl]-acetamide
  参考文献：
  名称：

  摘要：

  Three-component condensation of 2-aminonaphthalene, acetone, and substituted benzaldehydes in alcoholic solution in the presence of concentrated hydrochloric acid gave 3-aryl-1-methylbenzo[f]quinolines. 1-Methyl-3-(nitrophenyl)benzo[f]quinolines were reduced to the corresponding amines which were converted into amides having a sulfonyl or chloroacetyl group in the aryl substituent.

  DOI：

  10.1023/a:1026077716902

文献信息

• ——
  作者：N. G. Kozlov、L. I. Basalaeva

  DOI：10.1023/a:1026077716902

  日期：——

  Three-component condensation of 2-aminonaphthalene, acetone, and substituted benzaldehydes in alcoholic solution in the presence of concentrated hydrochloric acid gave 3-aryl-1-methylbenzo[f]quinolines. 1-Methyl-3-(nitrophenyl)benzo[f]quinolines were reduced to the corresponding amines which were converted into amides having a sulfonyl or chloroacetyl group in the aryl substituent.