1-甲氧基-2-甲基环己烯 | 1728-38-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-甲氧基-2-甲基环己烯
• 英文名称: methyl enol ether of 2-methylcyclohexanone
• 英文别名: 1-methoxy-2-methylcyclohex-1-ene；1-methoxy-2-methylcyclohexene；2-methyl-1-methoxycyclohexene；1-Methoxy-2-methyl-1-cyclohexen；1-Methoxy-2-methyl-cyclohexen；1-Methoxy-2-methylcyclohexen；Cyclohexene, 1-methoxy-2-methyl-
• CAS: 1728-38-7
• 化学式: C₈H₁₄O
• 分子量: 126.199
• InChiKey: YSAZFHDEUZHTIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-甲氧基-2-甲基环己烯 在 sodium hydroxide 、 氧气 、 对甲苯磺酸 、 copper dichloride 、 palladium dichloride 作用下， 以 甲醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 生成 (R)-(-)-4a-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalene-2-one
  参考文献：
  名称：

  手性2，2-二取代的环己酮；环通过克莱森重排产物

  摘要：

  2-甲基环己酮的甲基烯醇醚与（R）-和（S）-但是-3-en-2-ol发生区域特异性和对映选择性反应，分别生成2-甲基的（R）-和（S）-形式-2-（反式-丁-2-烯基）环己酮。

  DOI：

  10.1039/c39880000043
• 作为产物：
  描述：

  1,1-dimethoxy-2-methylcyclohexane 生成 1-甲氧基-2-甲基环己烯
  参考文献：
  名称：

  Synthesis of peroxide compounds by the BF₃-catalyzed reaction of acetals and enol ethers with H₂O₂

  摘要：

  DOI：

  10.1023/b:rucb.0000035657.58776.cc

文献信息

• [EN] TRIAZOLE CARBAMATE PYRIDYL SULFONAMIDES AS LPA RECEPTOR ANTAGONISTS AND USES THEREOF<br/>[FR] PYRIDYLSULFONAMIDES DE CARBAMATE DE TRIAZOLE UTILISÉES EN TANT QU'ANTAGONISTES DU RÉCEPTEUR DE LPA ET LEURS UTILISATIONS
  申请人：GILEAD SCIENCES INC

  公开号：WO2021097039A1

  公开（公告）日：2021-05-20

  The present disclosure relates generally to compounds of Formula (I) that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of LPAR1, including fibrosis and liver diseases such as non-alcoholic steatohepatitis (NASH).

  本公开涉及通常与结合到溶酶磷脂酸受体1（LPAR1）并作为LPAR1拮抗剂的化合物的公式（I）有关。本公开进一步涉及利用这些化合物制备药物治疗通过结合LPAR1引起的疾病和/或病况，包括纤维化和肝病，如非酒精性脂肪性肝炎（NASH）。
• Chiral 2,2-disubstituted cyclohexanones; annulation via Claisen rearrangement products
  作者：T. J. Grattan、J. S. Whitehurst

  DOI：10.1039/c39880000043

  日期：——

  The methyl enol ether of 2-methylcyclohexanone reacts regiospecifically and enantioselectively with (R)- and (S)-but-3-en-2-ol to give respectively, the (R)- and (S)- forms of 2-methyl-2-(trans-but-2-enyl)cyclohexanone.

  2-甲基环己酮的甲基烯醇醚与（R）-和（S）-但是-3-en-2-ol发生区域特异性和对映选择性反应，分别生成2-甲基的（R）-和（S）-形式-2-（反式-丁-2-烯基）环己酮。
• A facile preparation of methyl enol ethers from acetals and ketals using trimethylsilyl iodide
  作者：R.D. Miller、D.R. McKean

  DOI：10.1016/s0040-4039(00)86821-5

  日期：1982.1

  Acetals and ketals are converted in high yields to the corresponding methyl vinyl ethers by treatment with trimethylsilyl iodide in the presence of hexamethyldisilazane at room temperature or below.

  通过在六甲基二硅氮烷存在下于室温或更低温度下用三甲基甲硅烷基碘化物处理，可以将乙缩醛和缩酮高产率地转化为相应的甲基乙烯基醚。
• Synthesis of substituted pyrano[3,2-c]pyridines via Diels–Alder reaction of 3-methylenepyridin-4-one
  作者：Kirill Tchabanenko、Marcus G.O. Taylor、Robert M. Adlington、Jack E. Baldwin

  DOI：10.1016/j.tetlet.2005.10.119

  日期：2006.1

  On heating, the di-Boc-pyridin-4-one derivative 7 gave an unstable 3-methylenepyridin-4-one intermediate 3, which underwent a rearomatising Diels–Alder cycloaddition with activated alkenes to give substituted pyrano[3,2-c]pyridines in moderate yields.

  加热时，二-Boc-吡啶-4-酮衍生物7生成不稳定的3-亚甲基吡啶-4-酮中间体3，将其与活化的烯烃进行Diels-Alder环加成反应，生成取代的吡喃并[3,2- c ]。吡啶的产率中等。
• Pt nanoparticle supported on nanocrystalline CeO₂: highly selective catalyst for upgradation of phenolic derivatives present in bio-oil
  作者：Bipul Sarkar、Chandrashekar Pendem、L. N. Sivakumar Konathala、Takehiko Sasaki、Rajaram Bal

  DOI：10.1039/c4ta04542d

  日期：——

  Pt nanoparticle supported on nanocrystalline CeO2 was prepared, and it was found that the catalyst can selectively hydrogenate phenolic derivatives present in bio-oil. The catalyst was characterized by XRD, XPS, ICP-AES, EXAFS, SEM and TEM. TEM micrograms confirm the presence of very small Pt nanoparticles supported on nanocrystalline CeO2. The catalyst was found to be very effective in liquid phase hydrogenation of phenol and phenolic compounds present in bio-oil in the presence of molecular H2. The synergy between the surface and very small Pt particles on the nanocrystalline CeO2 plays the most vital role towards the extremely high catalytic activity of the catalyst. The reusability of the catalyst was tested, and it was found that the catalyst does not exhibit any significant change in its catalytic activity even after five reuses. The catalyst showed ∼100% conversion with very high selectivity after 3 h in phenol conversions of 100% with >98% cyclohexanol selectivity achieved after 3 h of reaction at 100 °C in aqueous medium.

  制备了纳米晶CeO2负载的Pt纳米颗粒，发现该催化剂可以选择性氢化生物油中存在的酚类衍生物。通过 XRD、XPS、ICP-AES、EXAFS、SEM 和 TEM 对催化剂进行了表征。 TEM 微克证实存在负载在纳米晶 CeO2 上的非常小的 Pt 纳米颗粒。研究发现，在分子 H2 存在下，该催化剂对于生物油中存在的苯酚和酚类化合物的液相加氢非常有效。纳米晶CeO2表面和极小的Pt颗粒之​​间的协同作用对于催化剂极高的催化活性起着至关重要的作用。对催化剂的重复使用性进行了测试，发现催化剂重复使用5次后其催化活性并未表现出明显变化。该催化剂在水性介质中于100℃反应3小时后，苯酚转化率为100%，环己醇选择性>98%，转化率约为100%，选择性非常高。