ethyl 3-(4-methoxy-pyridin-2-yl)propionate | 35475-63-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ethyl 3-(4-methoxy-pyridin-2-yl)propionate
• 英文别名: ethyl 3-(4-methoxy-2-pyridyl)propionate；3-(4-methoxy-pyridin-2-yl)-propionic acid ethyl ester；ethyl 3-(4methoxy-pyridin-2-yl)propionate；ethyl 3-(4methoxy-2-pyridyl)propionate；Ethyl-4-methoxy-2-pyridinepropionat；Ethyl 3-(4-methoxypyridin-2-yl)propanoate
• CAS: 35475-63-9
• 化学式: C₁₁H₁₅NO₃
• 分子量: 209.245
• InChiKey: ZCRKORXUYDWWKU-UHFFFAOYSA-N

物化性质

• 沸点：
  298.4±25.0 °C(Predicted)
• 密度：
  1.087±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  48.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 3-(4-methoxy-pyridin-2-yl)propionate 在 sodium methylate 、 sodium hydride 作用下， 以 甲醇 、 乙二醇二甲醚 、 乙醇 为溶剂， 反应 62.0h， 生成 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(4-methoxy-pyridin-2-ylmethyl)-4-pyrimidone
  参考文献：
  名称：

  Isocytosine H2-receptor histamine antagonists. IV. The synthesis and biological activity of donetidine (SK&F 93574) and related compounds

  摘要：

  The synthesis and biological activity of some novel 2-amino-4-pyrimidone derivatives is described. Side-chains associated with H-2-antagonist activity am attached through the 2-amino group, whilst a range of 2-hydroxypyridine containing moieties are substituted at the 5-position of the pyrimidone ring. Good H-2-receptor histamine antagonist activity is observed with all the series and the majority of the compounds are selective for the H-2-receptor. High aqueous solubility and iv potency coupled with an extended duration of biological activity in animal models led to compound 16c, 2-[2-(5-dimethylaminomethyl-2-furanylmethyl-thio)ethylamino]-5-(2-hydroxypyrid-4-ylmethyl)-4-pyrimidone (donetidine, SK&F 93574) being selected for clinical investigation as a potential parenterally administered therapeutic agent.

  DOI：

  10.1016/0223-5234(93)90091-r
• 作为产物：
  描述：

  4-甲氧基吡啶-2-醛 在 palladium on activated charcoal 哌啶 、 吡啶 、 氢气 作用下， 以 乙醇 为溶剂， 生成 ethyl 3-(4-methoxy-pyridin-2-yl)propionate
  参考文献：
  名称：

  Isocytosine H2-receptor histamine antagonists. IV. The synthesis and biological activity of donetidine (SK&F 93574) and related compounds

  摘要：

  The synthesis and biological activity of some novel 2-amino-4-pyrimidone derivatives is described. Side-chains associated with H-2-antagonist activity am attached through the 2-amino group, whilst a range of 2-hydroxypyridine containing moieties are substituted at the 5-position of the pyrimidone ring. Good H-2-receptor histamine antagonist activity is observed with all the series and the majority of the compounds are selective for the H-2-receptor. High aqueous solubility and iv potency coupled with an extended duration of biological activity in animal models led to compound 16c, 2-[2-(5-dimethylaminomethyl-2-furanylmethyl-thio)ethylamino]-5-(2-hydroxypyrid-4-ylmethyl)-4-pyrimidone (donetidine, SK&F 93574) being selected for clinical investigation as a potential parenterally administered therapeutic agent.

  DOI：

  10.1016/0223-5234(93)90091-r

文献信息

• Indolizine derivatives with biological activity VI 1-(2-aminoethyl)-3-benzyl-7-methoxy-2-methylindolizine, benanserin structural analogue
  作者：GM Cingolani、F Claudi、M Massi、F Venturi

  DOI：10.1016/0223-5234(90)90138-s

  日期：1990.10
• 2-nitro aminopyrimidone derivatives, a process for their preparation and their use to prepare 2-aminopyrimidone derivatives which have histamine H2-antagonist activity
  申请人：SMITH KLINE & FRENCH LABORATORIES LIMITED

  公开号：EP0004793B1

  公开（公告）日：1981-12-30
• Pyrimidones, processes for their preparation and pharmaceutical compositions containing them
  申请人：SMITH KLINE & FRENCH LABORATORIES LIMITED

  公开号：EP0003677B1

  公开（公告）日：1981-11-11
• CINGOLANI, G. M.;CLAUDI, F.;MASSI, M.;VENTURI, F., EUR. J. MED. CHEM., 25,(1990) N, C. 709-712
  作者：CINGOLANI, G. M.、CLAUDI, F.、MASSI, M.、VENTURI, F.

  DOI：——

  日期：——
• Pyrimidone derivatives, process for preparing them and pharmaceutical compositions containing them
  申请人：SMITH KLINE & FRENCH LABORATORIES LIMITED

  公开号：EP0017680B1

  公开（公告）日：1982-04-21