[1]Benzothieno[3,2-b]quinolin-11(5H)-one, 2-iodo- | 919832-55-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: [1]Benzothieno[3,2-b]quinolin-11(5H)-one, 2-iodo-
• 英文别名: 2-iodo-5H-benzothieno[3,2-b]quinolin-11-one
• CAS: 919832-55-6
• 化学式: C₁₅H₈INOS
• 分子量: 377.205
• InChiKey: UAYYEAPZRJONGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  19.0
• 可旋转键数：
  0.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  32.86
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  [1]Benzothieno[3,2-b]quinolin-11(5H)-one, 2-iodo- 在 palladium on activated charcoal 氢气 、 溶剂黄146 、 三氯氧磷 作用下， 以 环丁砜 、 N,N-二甲基甲酰胺 为溶剂， 20.0~160.0 ℃ 、448.16 kPa 条件下， 反应 48.0h， 生成 5-Methyl-[1]benzothiolo[3,2-b]quinolin-5-ium-2-carbonitrile;iodide
  参考文献：
  名称：

  Synthesis and evaluation of isosteres of N-methyl indolo[3,2-b]-quinoline (cryptolepine) as new antiinfective agents

  摘要：

  Isosteres of cryptolepine (1) were synthesized and evaluated for their antiinfective activities. Overall, the sulfur isostere, 5-methyl benzothieno[3,2-b]quinolinium salt (5b), was equipotent to 1 and has shown no cytotoxicity at 23.8 mu g/mL. Compound 5b was also found to have a broad spectrum of activity. Both the carbon and oxygen isosteres were less potent than cryptolepine. A limited library of 2-substituted analogs of 5b has been synthesized and evaluated in antifungal screens but did not show increase in potency compared to the unsubstituted 5b. Similarly, evaluation of tricyclic benzothieno[3,2-b]pyridines while showing promise in individual screens did not produce an overall increase in potency. Overall, the evaluation of the activities of 5b compared with standard antifungal/anti-protozoal agents suggests that the benzothienoquinoline scaffold could serve as a lead for optimization. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.10.062
• 作为产物：
  描述：

  (苯基硫醇)乙酰氯 在 sodium hydroxide 、 PPA 作用下， 以 水 为溶剂， 反应 6.0h， 生成 [1]Benzothieno[3,2-b]quinolin-11(5H)-one, 2-iodo-
  参考文献：
  名称：

  Synthesis and evaluation of isosteres of N-methyl indolo[3,2-b]-quinoline (cryptolepine) as new antiinfective agents

  摘要：

  Isosteres of cryptolepine (1) were synthesized and evaluated for their antiinfective activities. Overall, the sulfur isostere, 5-methyl benzothieno[3,2-b]quinolinium salt (5b), was equipotent to 1 and has shown no cytotoxicity at 23.8 mu g/mL. Compound 5b was also found to have a broad spectrum of activity. Both the carbon and oxygen isosteres were less potent than cryptolepine. A limited library of 2-substituted analogs of 5b has been synthesized and evaluated in antifungal screens but did not show increase in potency compared to the unsubstituted 5b. Similarly, evaluation of tricyclic benzothieno[3,2-b]pyridines while showing promise in individual screens did not produce an overall increase in potency. Overall, the evaluation of the activities of 5b compared with standard antifungal/anti-protozoal agents suggests that the benzothienoquinoline scaffold could serve as a lead for optimization. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.10.062