7-Chloro-8,10,18,20-tetrahydroxy-17-methoxy-13-oxa-2-azatricyclo[14.3.1.06,11]icosa-1(19),6(11),7,9,16(20),17-hexaene-3,12-dione | 913622-76-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: 7-Chloro-8,10,18,20-tetrahydroxy-17-methoxy-13-oxa-2-azatricyclo[14.3.1.06,11]icosa-1(19),6(11),7,9,16(20),17-hexaene-3,12-dione
• CAS: 913622-76-1
• 化学式: C₁₉H₁₈ClNO₈
• 分子量: 423.807
• InChiKey: CKYYTXNOHZNMJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  29
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  146
• 氢给体数：
  5
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  7-Chloro-8,10,18,20-tetrahydroxy-17-methoxy-13-oxa-2-azatricyclo[14.3.1.06,11]icosa-1(19),6(11),7,9,16(20),17-hexaene-3,12-dione 在 palladium on activated charcoal air 作用下， 以 甲醇 、 乙酸乙酯 为溶剂， 反应 2.0h， 以70%的产率得到7-Chloro-8,10-dihydroxy-17-methoxy-13-oxa-2-aza-tricyclo[14.3.1.0^6,11]icosa-1(19),6(11),7,9,16-pentaene-3,12,18,20-tetraone
  参考文献：
  名称：

  Design, Synthesis, and StructureActivity Relationships for Chimeric Inhibitors of Hsp90

  摘要：

  Inhibition of the 90 kDa heat shock protein (Hsp90) family of molecular chaperones represents a promising new chemotherapeutic approach toward the treatment of several cancers. Previous studies have demonstrated that the natural products, radicicol and geldanamycin, are potent inhibitors of the Hsp90 N-terminal ATP binding site. The cocrystal structures of these molecules bound to Hsp90 have been determined, and through molecular modeling and superimposition of these ligands, hybrids of radicicol and geldanamycin have been designed. A series of macrocylic chimeras of radicicol and geldanamycin and the corresponding seco-agents have been prepared and evaluated for both antiproliferative activity and their ability to induce Hsp90-dependent client protein degradation.

  DOI：

  10.1021/jo061054f
• 作为产物：
  描述：

  2-甲氧基对苯二酚 在 palladium on activated charcoal 硝酸铵 、 2,6-二甲基吡啶 、 sodium chlorite 、 sodium periodate 、 sodium dihydrogenphosphate 、 四氧化锇 、 正丁基锂 、 三甲基氯硅烷 、 2-甲基-2-丁烯 、 四甲基乙二胺 、 偶氮二甲酸二异丙酯 、 氢气 、 sodium hydride 、 1-羟基苯并三唑 、 N,N-二异丙基乙胺 、 三苯基膦 、 三氟乙酸酐 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 、 sodium iodide 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 乙醇 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 、 乙腈 、 叔丁醇 为溶剂， 反应 34.16h， 生成 7-Chloro-8,10,18,20-tetrahydroxy-17-methoxy-13-oxa-2-azatricyclo[14.3.1.06,11]icosa-1(19),6(11),7,9,16(20),17-hexaene-3,12-dione
  参考文献：
  名称：

  Design, Synthesis, and StructureActivity Relationships for Chimeric Inhibitors of Hsp90

  摘要：

  Inhibition of the 90 kDa heat shock protein (Hsp90) family of molecular chaperones represents a promising new chemotherapeutic approach toward the treatment of several cancers. Previous studies have demonstrated that the natural products, radicicol and geldanamycin, are potent inhibitors of the Hsp90 N-terminal ATP binding site. The cocrystal structures of these molecules bound to Hsp90 have been determined, and through molecular modeling and superimposition of these ligands, hybrids of radicicol and geldanamycin have been designed. A series of macrocylic chimeras of radicicol and geldanamycin and the corresponding seco-agents have been prepared and evaluated for both antiproliferative activity and their ability to induce Hsp90-dependent client protein degradation.

  DOI：

  10.1021/jo061054f

文献信息

• Heat shock protein 90 inhibitors
  申请人：Blagg Brian

  公开号：US20070197787A1

  公开（公告）日：2007-08-23

  Novel compounds useful for inhibiting the 90 kDa heat shock proteins containing a quinone-like moiety and a di-hydroxy phenol like moiety, similar to geldanamycin and radicicol.
• HEAT SHOCK PROTEIN 90 INHIBITORS
  申请人：Blagg Brian S.J.

  公开号：US20100099865A1

  公开（公告）日：2010-04-22

  Novel compounds useful for inhibiting the 90kDa heat shock proteins containing a quinone-like moiety and a di-hydroxy phenol like moiety, similar to geldanamycin and radicicol.
• US7208630B2
  申请人：——

  公开号：US7208630B2

  公开（公告）日：2007-04-24
• US7605288B2
  申请人：——

  公开号：US7605288B2

  公开（公告）日：2009-10-20
• US8188306B2
  申请人：——

  公开号：US8188306B2

  公开（公告）日：2012-05-29