Improved processes for the preparation and purification of maytansinoid esters, especially thiol and disulfide-containing maytansinoids are described. In one aspect the process comprises a process of making a maytansinoid ester comprising forming an anion of maytansinol or a maytansinoid bearing a free C-3 hydroxyl moiety and reacting the anion with an activated carboxyl compound to thereby produce the maytansinoid ester.
描述了用于制备和纯化美坦西
酯类化合物的改进过程,特别是含有
硫醇和二
硫键的美坦西
酯类化合物。在一个方面,该过程包括制备美坦西
酯类化合物的过程,其中包括形成美坦西醇或带有游离C-3羟基的美坦西
酯类化合物的阴离子,并将该阴离子与活化的羧基化合物反应,从而产生美坦西
酯类化合物。