1,4-Dipropionyl-benzol | 17558-64-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,4-Dipropionyl-benzol
• 英文别名: 1,4-Dipropionylbenzene；1-(4-propanoylphenyl)propan-1-one
• CAS: 17558-64-4
• 化学式: C₁₂H₁₄O₂
• 分子量: 190.242
• InChiKey: RJJQKFVSENWLLE-UHFFFAOYSA-N

物化性质

• 熔点：
  34 °C
• 沸点：
  327.4±25.0 °C(Predicted)
• 密度：
  1.025±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,4-Dipropionyl-benzol 在 盐酸 、 溶剂黄146 作用下， 以 乙醇 、 水 为溶剂， 反应 6.0h， 生成 1,4-双-(3-氰基-2-甲基丙酰基)苯
  参考文献：
  名称：

  1,4-Bis(3-oxo-2,3-dihydropyridazin-6-yl)benzene analogs: potent phosphodiesterase inhibitors and inodilators

  摘要：

  1,4-Bis(3-oxo-2,3-dihydropyridazin-6-yl)benzene and a series of related bis(azinone) compounds were synthesized. These novel compounds were evaluated for inhibition of the low Km, cAMP-selective, cGMP-inhibited phosphodiesterase (PDE III) derived from cat heart and hemodynamic activity in the ganglion- and beta-blocked anesthetized cat. The most potent PDE III inhibitor of the series was 6-[4-(5-methyl-3-oxo-2,3,4,5-tetrahydropyridazin-6-yl)-phenyl]p yridazin- 3(2H)-one (IC50 = 0.07 microM), which also retained the greatest inotrope and vasodilator (inodilator) potency (ED50 for first derivative of left ventricular pressure (dLVP/dt(max)) = 0.02 mumol/kg, ED15 for 15% fall in perfusion pressure = 0.01 mumol/kg). The structure-activity relationships observed within the bis(azinone) series were consistent with those reported for formally analogous 6-(4-substituted-phenyl)pyridazin-3(2H)-one-based PDE III-inhibiting inodilators with less-extended phenyl substituents (see e.g. Sircar et al. J. Med. Chem. 1987, 30, 1955, Moos et al. J. Med. Chem. 1987, 30, 1963). PDE III inhibitory potency is associated with overall planar topology of the phenylpyridazinone moiety and the presence of two critically separated electronegative centers. A methyl group at the 5-position of a dihydropyridazinone ring leads to enhanced potency. However, the generally higher levels of PDE III inhibitory potency shown by compounds in the bis(azinone) series relative to earlier 6-(4-substituted-phenyl)pyridazin-3(2H)-one derivatives appears to derive from a closer to optimal separation of two interacting points in the inhibitor molecule achieved through the more extended bis(azinone) structure. Correlation between the pharmacological and PDE III inhibitory activities of compounds in the bis(azinone) series provides additional evidence for PDE III being an important mediator of inodilator action.

  DOI：

  10.1021/jm00168a031
• 作为产物：
  描述：

  1,4-二烯丙基苯 在 叔丁基过氧化氢 、 palladium diacetate 、 对甲苯磺酸 作用下， 以 水 、 乙腈 为溶剂， 反应 9.0h， 以98%的产率得到1,4-Dipropionyl-benzol
  参考文献：
  名称：

  Direct conversion of allyl arenes to aryl ethylketones via a TBHP-mediated palladium-catalyzed tandem isomerization–Wacker oxidation of terminal alkenes

  摘要：

  通过TBHP介导的钯催化串联异构化-Wacker氧化反应，成功开发了对末端烯烃的反应。

  DOI：

  10.1039/c5ob00586h

文献信息

• Benzene compounds having two pyridazinone substituents
  申请人：Smith Kline & French Laboratories Limited

  公开号：US04904664A1

  公开（公告）日：1990-02-27

  The invention relates to pyridazinone derivatives which have inotropic, vasodilator and bronchodilator activity. The compounds of the invention are described by formula (I): ##STR1## wherein: R.sup.1 is hydrogen or methyl; R.sup.2 is hydrogen or methyl; and represent double or single bonds; and the benzene ring is para- or meta-substituted; and pharmaceutically acceptable salts thereof.

  该发明涉及具有肌力作用、血管扩张作用和支气管扩张作用的吡啶并咪唑酮衍生物。该发明的化合物由以下式（I）描述： 其中：R.sup.1 为氢或甲基；R.sup.2 为氢或甲基；并表示双键或单键；苯环为对位或间位取代；及其药用可接受的盐。
• Liquid detergent compositions with low polydispersity polyacrylic acid based polymers
  申请人：Gardner Robb Richard

  公开号：US20080318832A1

  公开（公告）日：2008-12-25

  Liquid detergent compositions comprising a polymer comprising polyacrylic acid monomers having a low number average molecular weight, ranging from about 1000 to about 10,000 amu, and a very low polydispersity, less than about 5, wherein the liquid detergent comprises less than about 50% of any non-aminofunctional solvent. The invention is also directed to liquid detergents compositions comprising beneficial mixtures of the low molecular weight, very low polydispersity polyacrylic acid based polymers with specific polymers.

  液体洗涤剂组成物包括聚合物，该聚合物包括聚丙烯酸单体，其具有低的数量平均分子量，范围从约1000到约10,000 amu，并且具有非常低的聚分散度，小于约5，其中液体洗涤剂包括少于约50％的任何非氨基功能溶剂。本发明还涉及低分子量、非常低聚分散度聚丙烯酸基聚合物与特定聚合物的有益混合物的液体洗涤剂组成物。
• Photosensitive compositions containing carbonylic halides as activators
  申请人：Dynachem Corporation

  公开号：EP0005379A2

  公开（公告）日：1979-11-14

  Compositions containing a polymerizable, curable or crosslinkable component. a photoinitiator, a colorformer capable of changing color upon contact with a suitable activator and a latent activator containing an organic halide will become insoluble and change color under the influence of actinic radiation. The organic halide is a carbonylic compound such as an aliphatic or cycloaliphatic ketone or an ester or amide of a dicarboxylic acid. The compositions are useful to make resists used in the electronics industry to manufacture printed circuits.

  含有可聚合、可固化或可交联成分、光引发剂、与适当活化剂接触后能变色的着色剂和含有有机卤化物的潜在活化剂的组合物，在光辐射的影响下会变得不溶解并变色。 有机卤化物是一种羰基化合物，如脂肪族或环脂族酮或二羧酸的酯或酰胺。 这些组合物可用于制造电子工业中用于制造印刷电路的抗蚀剂。
• Phototropic photosensitive compositions containing a fluoran colorformer
  申请人：Dynachem Corporation

  公开号：EP0005380A2

  公开（公告）日：1979-11-14

  Compositions containing a polymerizable, curable or crosslinkable component, a photoinitiator, a fluoran colorformer and a latent activator that releases or promotes the release of a Lewis acid, will become insoluble and change color under the influence of actinic radiation. These compositions are particularly useful to make dry film photoresists, which are widely used in the electronics industry to manufacture printed circuits.

  含有可聚合、可固化或可交联成分、光引发剂、荧光显色剂和可释放或促进释放路易斯酸的潜在活化剂的组合物，在光辐射的影响下会变得不溶解并改变颜色。这些成分特别适用于制造干膜光阻，干膜光阻在电子工业中广泛用于制造印刷电路。
• 6-Oxo-pyridazinyl compounds
  申请人：SMITH KLINE & FRENCH LABORATORIES LIMITED

  公开号：EP0208517A2

  公开（公告）日：1987-01-14

  Compounds of the formula (I) : and pharmaceutically acceptable salts are described wherein R¹ is hydrogen or methyl; R² is hydrogen or methyl; .... and ---- represent double or single bonds; and the benzene ring is para- or meta-substituted. These compounds have inotropic and vasodilator properties. Pharmaceutical compositions and methods of use are described.

  式 (I) ： 和药学上可接受的盐，其中 R¹ 是氢或甲基；R² 是氢或甲基；.... 和 ---- 代表双键或单键；苯环是对位或偏取代的。这些化合物具有肌力和血管扩张特性。描述了药物组合物和使用方法。