MSX-213 | 219872-32-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: MSX-213
• 英文别名: 1,4-bis(2-pyridyloxymethyl)benzene；US9205085, Msx-213；2-[[4-(pyridin-2-yloxymethyl)phenyl]methoxy]pyridine
• CAS: 219872-32-9
• 化学式: C₁₈H₁₆N₂O₂
• 分子量: 292.337
• InChiKey: ALFCXBNXARIHLT-UHFFFAOYSA-N

物化性质

• 沸点：
  439.7±35.0 °C(Predicted)
• 密度：
  1.191±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  44.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  silver nitrate 、 MSX-213 以 水 、 丙酮 为溶剂， 以79%的产率得到Ag⁽¹⁺⁾*NO₃^(1-)*C₆H₄(CH₂OC₅H₄N)2 = [Ag(NO₃)(C₆H₄(CH₂OC₅H₄N)2)]
  参考文献：
  名称：

  Hartshorn, Chris M.; Steel, Peter J., Journal of the Chemical Society, Dalton Transactions, 1998, # 23, p. 3927 - 3933

  摘要：

  DOI：
• 作为产物：
  描述：

  2-溴吡啶 、 对苯二甲醇 在 氢氧化钾 作用下， 以 甲苯 为溶剂， 反应 42.0h， 以34%的产率得到MSX-213
  参考文献：
  名称：

  Hartshorn, Chris M.; Steel, Peter J., Journal of the Chemical Society, Dalton Transactions, 1998, # 23, p. 3927 - 3933

  摘要：

  DOI：

文献信息

• [EN] TRICYCLIC AMINO CONTAINING COMPOUNDS FOR TREATMENT OR PREVENTION OF SYMPTOMS ASSOCIATED WITH ENDOCRINE DYSFUNCTION<br/>[FR] COMPOSÉS CONTENANT DES ACIDES AMINÉS TRICYCLIQUES POUR LE TRAITEMENT OU LA PRÉVENTION DE SYMPTÔMES ASSOCIÉS À UN DYSFONCTIONNEMENT ENDOCRINIEN
  申请人：UNIV EMORY

  公开号：WO2013070660A1

  公开（公告）日：2013-05-16

  The disclosure provides methods of use of certain compounds that are useful for treating certain symptoms of endocrine disturbances, and in particular those associated with hot flashes.

  本公开提供了使用某些化合物治疗内分泌紊乱的某些症状的方法，特别是与潮热相关的症状的方法。
• Tricyclic amino containing compounds for treatment or prevention of symptoms associated with endocrine dysfunction
  申请人：Emory University

  公开号：US10632120B2

  公开（公告）日：2020-04-28

  The disclosure provides methods of use of certain compounds that are useful for treating certain symptoms of endocrine disturbances, and in particular those associated with hot flashes.

  本公开提供了某些化合物的使用方法，这些化合物可用于治疗内分泌紊乱的某些症状，尤其是与潮热相关的症状。
• TRICYCLIC AMINO CONTAINING COMPOUNDS FOR TREATMENT OR PREVENTION OF SYMPTOMS ASSOCIATED WITH ENDOCRINE DYSFUNCTION
  申请人：Emory University

  公开号：EP2776387B1

  公开（公告）日：2017-02-01
• CXCR4 antagonists for the treatment of medical disorders
  申请人：Shim Hyunsuk

  公开号：US20070054930A1

  公开（公告）日：2007-03-08

  The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor for the treatment of proliferative conditions mediated by CXCR4 receptors. The compounds provided interfere with the binding of SDF1 to the receptor. These compounds are particularly useful for treating or reducing the severity of hyperproliferative diseases by inhibiting metastasis.
• CXCR4 Antagonists Including Heteroatoms for the Treatment of Medical Disorders
  申请人：Liotta Dennis C.

  公开号：US20080227799A1

  公开（公告）日：2008-09-18

  The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor for the treatment of proliferative conditions mediated by CXCR4 receptors. The compounds provided interfere with the binding of SDF1 to the receptor. These compounds are particularly useful for treating or reducing the severity of hyperproliferative diseases by inhibiting metastasis.