3-isothiocyanato-benzenesulfonic acid | 70120-95-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-isothiocyanato-benzenesulfonic acid
• 英文别名: 3-Isothiocyanato-benzolsulfonsaeure；3-Isothiocyanatobenzene-1-sulfonic acid；3-isothiocyanatobenzenesulfonic acid
• CAS: 70120-95-5
• 化学式: C₇H₅NO₃S₂
• 分子量: 215.254
• InChiKey: GAPFLLKQXGZRRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  107
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  硫光气 、 alkaline earth salt of/the/ methylsulfuric acid 在 溶剂黄146 作用下， 生成 3-isothiocyanato-benzenesulfonic acid
  参考文献：
  名称：

  Dyson, Recueil des Travaux Chimiques des Pays-Bas, 1938, vol. 57, p. 1016,1026

  摘要：

  DOI：

文献信息

• [EN] COMPOUND FOR DERIVATIZING POLYPEPTIDES AND METHOD FOR SEQUENCING AND QUANTIFIFYING AMINO ACIDS IN POLYPEPTIDES USING THE SAME<br/>[FR] COMPOSE PERMETTANT DE DERIVER DES POLYPEPTIDES, ET PROCEDE DE SEQUENÇAGE ET DE QUANTIFICATION D'ACIDES AMINES DANS DES POLYPEPTIDES FAISANT APPEL AUDIT COMPOSE
  申请人：UNIV KOREA IND & ACAD COOP

  公开号：WO2006004341A1

  公开（公告）日：2006-01-12

  The present invention relates to a compound for N-terminal substitution of polypeptides which is used in sequencing and quantifying amino acids and a method for sequencing and quantifying an amino acid sequence using the same. The method for sequencing and quantifying amino acids in accordance with the present invention leads to a relative quantitative analysis of proteins with very high reliability, and can distinctively discriminate between y-type ions and b-type ions on the MS/MS spectra, providing the means for realization of high-reliability protein identification.

  本发明涉及一种用于多肽N-末端替换的化合物，用于测序和定量氨基酸以及使用该化合物进行氨基酸序列测序和定量的方法。根据本发明的氨基酸测序和定量方法可以实现非常高可靠性的蛋白质相对定量分析，并且可以在MS / MS光谱上明显区分y型离子和b型离子，为实现高可靠性的蛋白质鉴定提供了手段。
• Desacetylthymosin alpha 1, its process of preparation and its use
  申请人：GENENTECH, INC.

  公开号：EP0035454A2

  公开（公告）日：1981-09-09

  The present invention concerns desacetylthymosin alpha 1, an immune restorative polypeptide hormone. This polypeptide is synthesized in E. coli using recombinant DNA cloning techniques. Based on the known amino acid sequence, a gene coding for thymosin alpha 1 was designed and enzymatically assembled from chemically synthesized oligodeoxyribonucleotide fragments. The gene was ligated into plasmid pBR322, placed under lac operon control, and thymosin alpha 1 expressed as part of a β-galactosidase chimeric protein. Cyanogen bromide cleavage of this protein gave a mixture of polypeptides among which thymosin alpha 1 was detected by radioimmunoassay. The E. coli product is identical to thymosin alpha 1 isolated from calf thymus in amino acid sequence and exhibits similar activity in a radioimmunoassay. The compound is hence a candidate for administration in effective immunopotentiating dosage in the treatment of immuno-depressed and immuno-suppressed conditions.

  本发明涉及一种免疫恢复性多肽激素--去乙酰胸腺肽α1。这种多肽是利用重组 DNA 克隆技术在大肠杆菌中合成的。根据已知的氨基酸序列，设计了胸腺肽α1 的编码基因，并用化学合成的寡脱氧核苷酸片段进行酶切组装。将该基因连接到质粒 pBR322 中，置于 lac 操作子控制下，胸腺肽α1 作为 β-半乳糖苷酶嵌合蛋白的一部分进行表达。该蛋白经溴化氰裂解后产生一种多肽混合物，其中胸腺肽α1可通过放射免疫法检测到。大肠杆菌产物与从小牛胸腺中分离出来的胸腺肽α1在氨基酸序列上完全相同，在放射免疫测定中也表现出相似的活性。 因此，该化合物可用于治疗免疫抑制和免疫抑制病症的有效免疫增强剂量。
• COMPOUND FOR DERIVATIZING POLYPEPTIDES AND METHOD FOR SEQUENCING AND QUANTIFIFYING AMINO ACIDS IN POLYPEPTIDES USING THE SAME
  申请人：Korea University Industry & Academy Cooperation...

  公开号：EP1763510A1

  公开（公告）日：2007-03-21
• EP1763510A4
  申请人：——

  公开号：EP1763510A4

  公开（公告）日：2008-05-21
• METHOD FOR SEQUENCING AND QUANTIFYING AMINO ACIDS IN POLYPEPTIDES
  申请人：Korea University Industry and Academy Cooperation Foundation

  公开号：EP1763510B1

  公开（公告）日：2014-06-18