α,β-dichloro-trans-cinnamic acid | 708-86-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: α,β-dichloro-trans-cinnamic acid
• 英文别名: α,β-dichloro-cinnamic acid；α,β-Dichlor-trans-zimtsaeure；α.β-Dichlor-β-phenyl-acrylsaeure；α,β-Dichlor-zimtsaeure；trans-α,β-Dichlor-zimtsaeure；(E)-2,3-dichloro-3-phenylprop-2-enoic acid
• CAS: 708-86-1
• 化学式: C₉H₆Cl₂O₂
• 分子量: 217.051
• InChiKey: VCVUNRNRXFHPQB-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  α,β-dichloro-trans-cinnamic acid 在 sodium hydroxide 、 硫酸 作用下， 生成 2-chloro-1,3-indandione
  参考文献：
  名称：

  Roser; Haselhoff, Justus Liebigs Annalen der Chemie, 1888, vol. 247, p. 149

  摘要：

  DOI：
• 作为产物：
  描述：

  α-Chlor-β-phenyl-acrylsaeure 在 二硫化碳 、 氢氧化钾 、 碘 、 氯 作用下， 生成 α,β-dichloro-trans-cinnamic acid
  参考文献：
  名称：

  Stoermer; Heymann, Chemische Berichte, 1913, vol. 46, p. 1265

  摘要：

  DOI：

文献信息

• Common ligand mimics: thiazolidinediones and rhodanines
  申请人：Yu Lin

  公开号：US20050042674A9

  公开（公告）日：2005-02-24

  The present invention provides common ligand mimics that act as common ligands for a receptor family. The present invention also provides bi-ligands containing these common ligand mimics. Bi-ligands of the invention provide enhanced affinity and/or selectivity of ligand binding to a receptor or receptor family through the synergistic action of the common ligand mimic and specificity ligand which compose the bi-ligand. The present invention also provides combinatorial libraries containing the common ligand mimics and bi-ligands of the invention. Further, the present invention provides methods for manufacturing the common ligand mimics and bi-ligands of the invention and methods for assaying the combinatorial libraries of the invention.

  本发明提供了作为受体家族通用配体的通用配体模拟物。本发明还提供了含有这些通用配体模拟物的双配体。本发明的双配体通过通用配体模拟物和组成双配体的特异性配体的协同作用，提供了对受体或受体家族的配体结合的增强亲和力和/或选择性。本发明还提供了含有通用配体模拟物和本发明的双配体的组合库。此外，本发明还提供了制造通用配体模拟物和本发明的双配体的方法以及检测本发明的组合库的方法。
• Common ligand mimics: pseudothiohydantoins
  申请人：Dong Qing

  公开号：US20050019825A9

  公开（公告）日：2005-01-27

  The present invention provides common ligand mimics that act as common ligands for a receptor family. The present invention also provides bi-ligands containing these common ligand mimics. Bi-ligands of the invention provide enhanced affinity and/or selectivity of ligand binding to a receptor or receptor family through the synergistic action of the common ligand mimic and specificity ligand that compose the bi-ligand. The present invention also provides combinatorial libraries containing the common ligand mimics and bi-ligands of the invention. Further, the present invention provides methods for manufacturing the common ligand mimics and bi-ligands of the invention and methods for assaying the combinatorial libraries of the invention.

  本发明提供了作为受体家族通用配体的通用配体模拟物。本发明还提供了含有这些通用配体模拟物的双配体。本发明的双配体通过通用配体模拟物和构成双配体的特异性配体的协同作用，提供了对受体或受体家族的配体结合的增强亲和力和/或选择性。本发明还提供了包含通用配体模拟物和本发明的双配体的组合化学库。此外，本发明还提供了制造通用配体模拟物和本发明的双配体的方法，以及对本发明的组合化学库进行检测的方法。
• Plastic optical fibers and transparent resin used therefor
  申请人：HITACHI, LTD.

  公开号：EP0226020A2

  公开（公告）日：1987-06-24

  A plastic optical fiber comprising a core and a clad, said core being formed by an amorphous and optically transparent polymer and said clad being formed by a polymer having a refractive index lower than that of the core by at least 0.3%, at least one of the core and the clad being formed by an amorphous and optically transparent polymer containing metal elements and halogen atoms, is low in light loss and excellent in heat resistance.

  一种塑料光纤，包括纤芯和包层，所述纤芯由无定形光学透明聚合物形成，所述包层由折射率比纤芯低至少 0.3% 的聚合物形成，纤芯和包层中至少有一个由含有金属元素和卤素原子的无定形光学透明聚合物形成，具有低光损耗和优异的耐热性。
• Thiazolo[5,4-b]azepine compounds
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0351856A2

  公开（公告）日：1990-01-24

  New thiazolo [5,4-b]azepine compounds represented by ,wherein R¹ is a hydrogen atom, an aliphatic group which may be substituted, a carboxylic acyl group which may be substituted or a sulfonic acyl group which may be substituted; R² is a hydrogen atom, an aromatic group which may be substituted or an aliphatic group which may be substituted, which are capable of e.g., inhibiting lipoperoxide formation.

  新的噻唑并[5,4-b]氮杂卓化合物，其代表如下 其中 R¹ 是氢原子、可被取代的脂肪族基团、可被取代的羧酸酰基或可被取代的磺酸酰基；R² 是氢原子、可被取代的芳香族基团或可被取代的脂肪族基团。
• Clarke, Journal of the Chemical Society, 1910, vol. 97, p. 895
  作者：Clarke

  DOI：——

  日期：——