1,5-bis-(norborn-2-yl)pentan-3-one | 60469-43-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 1,5-bis-(norborn-2-yl)pentan-3-one
• 英文别名: 1,5-Bis(2-bicyclo[2.2.1]heptanyl)pentan-3-one
• CAS: 60469-43-4
• 化学式: C₁₉H₃₀O
• 分子量: 274.447
• InChiKey: UPNIECGURUSFKR-UHFFFAOYSA-N

物化性质

• 沸点：
  352.5±10.0 °C(Predicted)
• 密度：
  1.013±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3,3'-二氨基二丙基胺 、 1,5-bis-(norborn-2-yl)pentan-3-one 在 铂 盐酸 作用下， 以 甲醇 、 乙醇 为溶剂， 生成 1-[1,5-Di-(2-norbornyl)-3-pentyl]-1,5,9-Triazanonane Trihydrochloride
  参考文献：
  名称：

  Di-bicyclo[3.1.1] and [2.2.1]heptyl and di-bicyclo[3.1.1] and

  摘要：

  新型二萜[3.1.1]和[2.2.1]庚基和二萜[3.1.1]和[2.2.1]庚烯基酮可作为制备新型聚胺的中间体，这些聚胺可用作抗微生物剂和藻类抑制剂。

  公开号：

  US04003934A1
• 作为产物：
  描述：

  3-(2-norbornyl)propionic acid 在 铁粉 作用下， 生成 1,5-bis-(norborn-2-yl)pentan-3-one
  参考文献：
  名称：

  Antibacterial N-[.omega.,.omega.'-bis(alicyclic and aryl)-sec-alkyl]poly(methylenetriamine and -tetramine) hydrochloride salts

  摘要：

  A series of antibacterial N-(omega, omega'-(cycloalkyl, bicyclo[2.2.1]heptyl, and alkyl-substituted phenyl)-sec-alkyl]poly(methylene)triamine and -tetramine hydrochloride salts were synthesized in an effort to develop efficient, nonsystemic inhibitors, particularly for Pseudomonas aeruginosa. In the 1,5,9-triazanonane group, 3 of 16 compounds were effective at 8--10 micrograms/mL against pseudomonads. Efficiency appeared more dependent upon lipophilicity of the nitrogen substituent than other characteristics represented by the three types of rings. A parabolic relationship was observed for the entire set between the hydrophobic parameter, pi, of the lipoidal moiety and minimal inhibitory concentration. One of 16 tetramines, 1-[1,5-bis(3,3-dimethyl-2-norbornyl)-3-pentyl]-1,5,9,13-tetraazatridecane tetrahydrochloride (26f), ranked similarly. An additional two compounds in each series were superior to several commercial cationic detergents in the control of the Gram-negative bacteria. None was inhibitory at up to 200 micrograms/mL for Proteus vulgaris.

  DOI：

  10.1021/jm00197a024

文献信息

• Dibicyclo[3.1.1] and [2.2.1] heptyl and dibicyclo [3.1.1] and [2.2.1]
  申请人：Merck & Co., Inc.

  公开号：US04033748A1

  公开（公告）日：1977-07-05

  Novel dibicyclo [3.1.1] and [2.2.1] heptyl and dibicyclo [3.1.1] and [2.2.1] heptenylalkyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful as hard surface disinfectants and as additives to oil well drilling muds, injection brines and industrial water where bacterial control is desired.

  新颖的双环[3.1.1]和[2.2.1]庚基和双环[3.1.1]和[2.2.1]庚烯基聚胺是有用的抗微生物剂，也是藻类抑制剂。它们特别适用于硬表面消毒剂，以及作为添加剂用于油井钻井泥浆、注入卤水和工业水中，以期望控制细菌。
• US4003934A
  申请人：——

  公开号：US4003934A

  公开（公告）日：1977-01-18
• US4058625A
  申请人：——

  公开号：US4058625A

  公开（公告）日：1977-11-15
• US4033748A
  申请人：——

  公开号：US4033748A

  公开（公告）日：1977-07-05
• US4035174A
  申请人：——

  公开号：US4035174A

  公开（公告）日：1977-07-12