2-溴-1-(4,5-二甲氧基-2-硝基苯基)乙酮 | 33245-76-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-溴-1-(4,5-二甲氧基-2-硝基苯基)乙酮
• 英文名称: 2-bromo-1-(4,5-dimethoxy-2-nitro-phenyl)-ethanone
• 英文别名: 2-Brom-1-(4,5-dimethoxy-2-nitro-phenyl)-aethanon；2-Bromo-1-(4,5-dimethoxy-2-nitrophenyl)ethanone
• CAS: 33245-76-0
• 化学式: C₁₀H₁₀BrNO₅
• 分子量: 304.097
• InChiKey: CCDONIOLJZLXJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  81.4
• 氢给体数：
  0
• 氢受体数：
  5

安全信息

• 海关编码：
  2914700090

反应信息

• 作为反应物：
  描述：

  2-溴-1-(4,5-二甲氧基-2-硝基苯基)乙酮 在 三氯氧磷 作用下， 以 氯仿 、 丙酮 为溶剂， 生成 6-(4,5-Dimethoxy-2-nitrophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde
  参考文献：
  名称：

  潜在的抗肿瘤药。37.由咪唑并[2，1-b]噻唑和新的杂环系统噻唑并[2′，3′：2，3]咪唑并[4，5-c]喹啉合成胍基hydr并具有抗肿瘤活性。

  摘要：

  本文报道了由咪唑并[2,1-b]噻唑和杂环新体系噻唑并[2'，3'：2,3]咪唑并[4,5-c]喹啉合成的新胍hydr及其抗肿瘤活性。这些化合物已在美国国家癌症研究所测试为潜在的抗肿瘤药物。研究了2-氯-6-（2,5-二甲氧基-4-硝基苯基）咪唑并[2,1-b]噻唑-5-甲醛的胍hydr的作用（41），发现其是抑制剂线粒体呼吸链复合物III的合成，能够诱导细胞株HT29和HL60凋亡。

  DOI：

  10.1021/jm040888s
• 作为产物：
  描述：

  1-(4,5-二甲氧基-2-硝基苯基)乙酮 在 溴 、 溶剂黄146 作用下， 生成 2-溴-1-(4,5-二甲氧基-2-硝基苯基)乙酮
  参考文献：
  名称：

  Adrenalinderivate mit kernständiger Aminogruppe

  摘要：

  DOI：

  10.1002/ardp.19392770303

文献信息

• A simple method for the synthesis of furfuryl ketones and furylacetic acid derivatives
  作者：Petrakis N. Chalikidi、Tatyana A. Nevolina、Maxim G. Uchuskin、Vladimir T. Abaev、Alexander V. Butin

  DOI：10.1007/s10593-015-1744-z

  日期：2015.7

  A simple preparative method has been developed for the synthesis of aryl(furfuryl) ketones, amides, and furylacetic acid esters, based on radical alkylation of furan derivatives at the α-position with О-ethyl(phenacyl)xanthogenates and phenacyl iodides in the presence of Fenton's reagent (H2O2/FeSO4 · 7H2O) in DMSO. The range of applicability and mechanisms for the formation of major and side products

  一种简单的方法制备已发展为芳基（糠基）酮，酰胺，和呋喃基乙酸酯的合成中，基于在与α位呋喃衍生物的烷基化基团О -乙基（苯甲酰甲基）黄原酸酯和苯甲酰甲基碘化物在存在DMSO中制备的Fenton试剂（H 2 O 2 / FeSO 4 ·7H2O）。已经考虑了主要和副产物形成的适用范围和机理。
• Studies on Chemotherapeutic Agents. I. Syntheses of Quinoline and Naphthyridine Sulfonamide or Phosphonic Acid Derivatives
  作者：HIROAKI YANAGISAWA、HIDEO NAKAO、AKIKO ANDO

  DOI：10.1248/cpb.21.1080

  日期：——

  Sulfonamide or phosphonic acid analogs of oxolinic acid (I) and nalidixic acid (II), in which the carboxyl groups of I and II were replaced by sulfamoyl and phosphono groups, were synthesized conveniently by the modification of the Camps'es quinoline synthesis. They were evaluated for antimicrobial activity but no significant activity was noted.

  合成了氧喹啉酸（I）和呋喃喹啉酸（II）的磺酰胺或磷酸类类似物，其中I和II的羧基被磺酰基和磷酸基取代。通过修改坎普斯喹啉合成法便利地合成了这些化合物。对其抗菌活性进行了评估，但未发现显著活性。
• C-TERMINAL AMIDATION OF POLYPEPTIDES
  申请人：Sun Chengzao

  公开号：US20140058070A1

  公开（公告）日：2014-02-27

  There are provided compounds and methods for amidating the C-terminus of a polypeptide. The method include reacting a polypeptide which includes a C-terminal thioester or C-terminal selenoester with any one of a defined set of auxiliary molecules under conditions suitable to produce a polypeptide adduct which includes the auxiliary molecule chemically bound at the C-terminal of the polypeptide. In the subsequent step, the auxiliary molecule is removed from the C-terminal of the polypeptide adduct under conditions suitable to produce an amidated polypeptide.
• US9249181B2
  申请人：——

  公开号：US9249181B2

  公开（公告）日：2016-02-02
• [EN] C-TERMINAL AMIDATION OF POLYPEPTIDES<br/>[FR] AMIDATION C-TERMINALE DE POLYPEPTIDES
  申请人：AMYLIN PHARMACEUTICALS INC

  公开号：WO2012036962A2

  公开（公告）日：2012-03-22

  There are provided compounds and methods for amidating the C-terminus of a polypeptide. The method include reacting a polypeptide which includes a C-terminal thioester or C-terminal selenoester with any one of a defined set of auxiliary molecules under conditions suitable to produce a polypeptide adduct which includes the auxiliary molecule chemically bound at the C- terminal of the polypeptide. In the subsequent step, the auxiliary molecule is removed from the C-terminal of the polypeptide adduct under conditions suitable to produce an amidated polypeptide.