phosphoric acid mono-[5(R)-(2-cyanothiophen-5-yl)-3,4-dihydroxytetrahydrofuran-2-yl-methyl] ester | 763139-84-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: phosphoric acid mono-[5(R)-(2-cyanothiophen-5-yl)-3,4-dihydroxytetrahydrofuran-2-yl-methyl] ester
• 英文别名: 5-[1'-(5'-O-phosphono-β-D-ribofuranosyl)]thiophene-2-carbonitrile
• CAS: 763139-84-0
• 化学式: C₁₀H₁₂NO₇PS
• 分子量: 321.248
• InChiKey: UNLCDRDDBWLKNV-QQRDMOCMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.11
• 重原子数：
  20.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  140.24
• 氢给体数：
  4.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  4-[二(环己基氨基)亚甲基]吗啉-4-鎓5'-O-(4-吗啉基磷酸基)腺苷 、 phosphoric acid mono-[5(R)-(2-cyanothiophen-5-yl)-3,4-dihydroxytetrahydrofuran-2-yl-methyl] ester 在 magnesium sulfate 、 manganese(ll) chloride 作用下， 以 formamide 为溶剂， 反应 96.0h， 以42%的产率得到[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(5-cyanothiophen-2-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate
  参考文献：
  名称：

  Novel nicotinamide adenine dinucleotide analogues as selective inhibitors of NAD+-dependent enzymes

  摘要：

  Three novel dinucleotide analogues of nicotinamide adenine dinucleotide (NAD(+)) have been synthesised from D-ribonolactone. These compounds incorporate a thiophene moiety in place of nicotinamide and are hydrolytically stable. They have been evaluated as inhibitors of adenosine diphosphate ribosyl cyclase, glutamate dehydrogenase and Sir2 acyltransferase activities. Enzyme specificity and a high level of inhibition was observed for the dehydrogenase. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.05.091
• 作为产物：
  描述：

  卡培他滨杂质25 在 三乙基硅烷 、 4-二甲氨基吡啶 、 potassium permanganate 、 正丁基锂 、 磷酸三乙酯 、 三氟甲磺酸三甲基硅酯 、 HCR-W₂ H⁺-Dowex resin 、 三乙胺 、 二异丙胺 、 三氯氧磷 作用下， 以 四氢呋喃 、 二氯甲烷 、 丙酮 、 正戊烷 为溶剂， 反应 17.5h， 生成 phosphoric acid mono-[5(R)-(2-cyanothiophen-5-yl)-3,4-dihydroxytetrahydrofuran-2-yl-methyl] ester
  参考文献：
  名称：

  Novel nicotinamide adenine dinucleotide analogues as selective inhibitors of NAD+-dependent enzymes

  摘要：

  Three novel dinucleotide analogues of nicotinamide adenine dinucleotide (NAD(+)) have been synthesised from D-ribonolactone. These compounds incorporate a thiophene moiety in place of nicotinamide and are hydrolytically stable. They have been evaluated as inhibitors of adenosine diphosphate ribosyl cyclase, glutamate dehydrogenase and Sir2 acyltransferase activities. Enzyme specificity and a high level of inhibition was observed for the dehydrogenase. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.05.091