2-氯-3-异丙基喹啉 | 85273-92-3

• 物质功能分类: 医药中间体 - 杂环化合物 - 喹啉类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 2-氯-3-异丙基喹啉
• 英文名称: 2-chloro-3-isopropylquinoline
• 英文别名: 2-chloro-3-propan-2-ylquinoline
• CAS: 85273-92-3
• 化学式: C₁₂H₁₂ClN
• 分子量: 205.687
• InChiKey: CBICQVIAVZYAIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2933499090

反应信息

• 作为反应物：
  描述：

  2-甲胺乙硫醇盐酸盐 、 2-氯-3-异丙基喹啉 在 sodium hydride 作用下， 生成 2-(2-dimethylaminoethylthio)-3-isopropylquinoline
  参考文献：
  名称：

  Synthesis and 5-hydroxytryptamine antagonist activity of 2-[[2-(dimethylamino)ethyl]thio]-3-phenylquinoline and its analogs

  摘要：

  A series of 2-[(2-aminoethyl)thio]quinolines substituted at the 3-position with alkyl, aryl, or heteroaryl groups has been prepared in the search for novel and selective 5-HT2 antagonists. The affinity of the compounds for 5-HT1 receptor sites was measured by their ability to displace [3H]-5-HT from rat brain synaptosomes whereas the affinity for 5-HT2 receptor sites was measured by their ability to displace [3H]spiperone from synaptosomes prepared from rat brain cortex. The 5-HT2 antagonist properties of the compounds were measured in vivo by their antagonism of 5-hydroxytryptophan-induced head twitches in the mouse and by their antagonism of hyperthermia induced by fenfluramine (N-ethyl-alpha-methyl-m-(trifluoromethyl)phenethylamine hydrochloride) in the rat. The structure-activity relationships in this series are discussed and the properties of 2-[[2-(dimethylamino)ethyl]thio]-3-phenylquinoline hydrochloride (70) are highlighted.

  DOI：

  10.1021/jm00395a013
• 作为产物：
  描述：

  Isopropyl quinolone 生成 2-氯-3-异丙基喹啉
  参考文献：
  名称：

  BLACKBURN, T. P.;COX, B.;GUILFORD, A. J.;LE, COUNT, D. J.;PEARCE, R. J.;T+

  摘要：

  DOI：

文献信息

• [EN] TRICYCLIC INDOLE DERIVATIVES AND METHODS OF USE THEREOF<br/>[FR] DÉRIVÉS D'INDOLE TRICYCLIQUES ET PROCÉDÉS D'UTILISATION DE CEUX-CI
  申请人：SCHERING CORP

  公开号：WO2009152200A1

  公开（公告）日：2009-12-17

  The present invention relates to Tricyclic Indole Derivatives, compositions comprising at least one Tricyclic Indole Derivatives, and methods of using the Tricyclic Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient

  本发明涉及三环吲哚衍生物，包括至少一种三环吲哚衍生物的组合物，以及利用该三环吲哚衍生物治疗或预防患者病毒感染或与病毒相关的疾病的方法。
• PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS
  申请人：Huang Taisheng

  公开号：US20110224190A1

  公开（公告）日：2011-09-15

  The present invention provides piperidin-4-yl azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase 1 (JAK1) and are useful in the treatment of diseases related to the activity of JAK1 including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

  本发明提供了哌啶-4-基氮杂环丙烷衍生物，以及它们的组合物和使用方法，这些衍生物调节Janus激酶1（JAK1）的活性，并且在治疗与JAK1活性相关的疾病方面具有用处，例如炎症性疾病、自身免疫性疾病、癌症和其他疾病。
• Quinoline derivatives which are 5-hydroxytryptamine antagonists
  申请人：Imperial Chemical Industries PLC

  公开号：US04435405A1

  公开（公告）日：1984-03-06

  Compounds of the formula: ##STR1## wherein A stands for the radical --(CH.sub.2).sub.2 -- which may bear one or two defined substituents; R.sup.1 stands for a (3-4C) alkyl or cyclopropyl radical, or a phenyl radical which may optionally bear one or two defined substituents, or a heteroaryl radical of five or six ring atoms which may optionally bear a (1-3C)alkyl substituent; R.sup.2 and R.sup.3 stand for hydrogen or a (1-2C)alkyl radical, or R.sup.2 stands for a (2-4C)alkylene radical which is linked to one of the carbon atoms forming the two-carbon-atom-backbone of A so as to form, together with the adjacent nitrogen atom, a pyrrolidinyl or piperidyl radical; and one of R.sup.4 and R.sup.5 stands for hydrogen, and the other stands for hydrogen, a halogen atom or a (1-3C)alkyl or (1-3C)alkoxy radical; and acid-addition salts thereof. Processes for the manufacture of said compounds. Pharmaceutical compositions comprising one of said compounds and a pharmaceutical diluent or carrier. The compounds are 5-hydroxytryptamine antagonists.

  化合物的化学式为：##STR1## 其中A代表基团--(CH.sub.2).sub.2 --，它可以带有一个或两个定义的取代基；R.sup.1代表一个(3-4C)烷基或环丙基基团，或一个苯基，它可以选择性地带有一个或两个定义的取代基，或一个由五个或六个环原子组成的杂环基团，它可以选择性地带有一个(1-3C)烷基取代基；R.sup.2和R.sup.3代表氢或(1-2C)烷基基团，或R.sup.2代表一个(2-4C)烷基基团，它与A的两个碳原子骨架中的一个形成连接，以便与相邻的氮原子一起形成吡咯烷基或哌嗪基团；R.sup.4和R.sup.5中的一个代表氢，另一个代表氢、卤素原子或(1-3C)烷基或(1-3C)烷氧基；以及它们的酸加成盐。制造这些化合物的方法。包含其中一种化合物和药物稀释剂或载体的制药组合物。这些化合物是5-羟色胺拮抗剂。
• 3-HETEROCYCLIC SUBSTITUTED INDOLE DERIVATIVES AND METHODS OF USE THEREOF
  申请人：Chan Tin-Yau

  公开号：US20110165118A1

  公开（公告）日：2011-07-07

  The present invention relates to 3-Heterocyclic Substituted Indole Derivatives, compositions comprising at least one 3-Heterocyclic Substituted Indole Derivative, and methods of using the 3-Heterocyclic Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.

  本发明涉及3-杂环取代吲哚衍生物，包括至少一种3-杂环取代吲哚衍生物的组合物，以及使用3-杂环取代吲哚衍生物治疗或预防患者的病毒感染或病毒相关疾病的方法。
• TRICYCLIC INDOLE DERIVATIVES AND METHODS OF USE THEREOF
  申请人：Venkatraman Srikanth

  公开号：US20110189127A1

  公开（公告）日：2011-08-04

  The present invention relates to Tricyclic Indole Derivatives, compositions comprising at least one Tricyclic Indole Derivatives, and methods of using the Tricyclic Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.

  本发明涉及三环吲哚衍生物、包含至少一种三环吲哚衍生物的组合物，以及使用三环吲哚衍生物治疗或预防患者的病毒感染或与病毒相关的疾病的方法。